Retinoid X Receptor (RXR) within the RXR-Retinoic Acid Receptor Heterodimer Binds Its Ligand and Enhances Retinoid-Dependent Gene Expression

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Identification of a nuclear receptor that is activated by farnesol metabolites

1995 • 1,134 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

Functional ecdysone receptor is the product of EcR and Ultraspiracle genes

1993 • 936 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

1992 • 583 citations

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

1995 • 569 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1994 • 432 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

1992 • 363 citations

Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.

1994 • 354 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Activation of Retinoid X Receptors Induces Apoptosis in HL-60 Cell Lines

1995 • 247 citations

Two distinct actions of retinoid-receptor ligands

1996 • 200 citations

Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism.

1993 • 185 citations

Synergistic Activation of Retinoic Acid (RA)-Responsive Genes and Induction of Embryonal Carcinoma Cell Differentiation by an RA Receptor α (RARα)-, RARβ-, or RARγ-Selective Ligand in Combination with a Retinoid X Receptor-Specific Ligand

1995 • 180 citations

9-cis retinoic acid signaling: changing partners causes some excitement.

1995 • 142 citations

Activation and Repression by Nuclear Hormone Receptors: Hormone Modulates an Equilibrium between Active and Repressive States

1996 • 135 citations

RXRalpha-null F9 embryonal carcinoma cells are resistant to the differentiation, anti-proliferative and apoptotic effects of retinoids.

1996 • 133 citations

Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping.

1994 • 125 citations

Retinoic Acid Receptors

1995 • 123 citations

Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.

1996 • 113 citations

Ligand-dependent conformational changes in the progesterone receptor are necessary for events that follow DNA binding.

1992 • 108 citations

Retinoic acid-mediated down-regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo.

1996 • 101 citations

Mouse Retinoid X Receptor Contains a Separable Ligand-Binding and Transactivation Domain in Its E Region

1995 • 95 citations

Ligand-dependent conformational changes in thyroid hormone and retinoic acid receptors are potentially enhanced by heterodimerization with retinoic X receptor

1993 • 92 citations

Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

1995 • 90 citations

Enhancement of HL-60 Differentiation by a New Class of Retinoids with Selective Activity on Retinoid X Receptor

1995 • 83 citations

Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and alpha-interferon in inhibition of cervical carcinoma cell proliferation.

1995 • 81 citations

Occupancy of upstream regulatory sites in vivo coincides with major histocompatibility complex class I gene expression in mouse tissues.

1992 • 76 citations

Steroid Binding Activity Is Retained in a 16-kDa Fragment of the Steroid Binding Domain of Rat Glucocorticoid Receptors

1989 • 75 citations

Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor- selective retinoic acid analogs

1996 • 69 citations

RAR and RXR selective ligands cooperatively induce apoptosis and neuronal differentiation in P19 embryonal carcinoma cells

1996 • 68 citations

Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.

1994 • 66 citations

Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo.

1994 • 65 citations

Retinoid receptors in transcriptional regulation

1996 • 63 citations

A ligand-induced conformational change in the estrogen receptor is localized in the steroid binding domain

1992 • 62 citations

Structure and Regulation of the Gene Encoding the Neuron-specific Protein Kinase C Substrate Neurogranin (RC3 Protein)

1995 • 61 citations

Retinoid-dependent in vitro transcription mediated by the RXR/RAR heterodimer.

1994 • 61 citations

Efficient Inhibition of Activation-induced Fas Ligand Up-regulation and T Cell Apoptosis by Retinoids Requires Occupancy of both Retinoid X Receptors and Retinoic Acid Receptors

1995 • 55 citations

Ligand-induced alteration of the protease sensitivity of retinoid X receptor alpha.

1994 • 55 citations

A cyclic AMP response element is involved in retinoic acid-dependent RARβ2 promoter activation

1992 • 53 citations

Ligand-dependent synergy of thyroid hormone and retinoid X receptors.

1992 • 53 citations

Individual Subunits of Heterodimers Comprised of Retinoic Acid and Retinoid X Receptors Interact with Their Ligands Independently

1996 • 52 citations

Characterization of the sequences of the human cytomegalovirus enhancer that mediate differential regulation by natural and synthetic retinoids.

1996 • 50 citations

Retinoid X receptor-selective ligands produce malformations in Xenopus embryos.

1996 • 47 citations

The Receptor-DNA Complex Determines the Retinoid Response: a Mechanism for the Diversification of the Ligand Signal

1996 • 45 citations

Endogenous Retinoid X Receptors Can Function as Hormone Receptors in Pituitary Cells

1994 • 41 citations

Conformational Changes of Human β1 Thyroid Hormone Receptor Induced by Binding of 3,3′,5-Triiodo-L-thyronine

1993 • 36 citations

Inhibition of ligand induced promoter occupancy in vivo by a dominant negative RXR

1996 • 19 citations

Genomic Footprinting of Retinoic Acid Regulated Promoters in Embryonal Carcinoma Cells

1997 • 15 citations

Deleted Work

1955 • 0 citations