Endogenous Retinoic Acid Receptor (RAR)-Retinoid X Receptor (RXR) Heterodimers Are the Major Functional Forms Regulating Retinoid-responsive Elements in Adult Human Keratinocytes

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2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

The retinoids—Biology, chemistry and medicine

1996 • 1,192 citations

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1988 • 1,049 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

The Retinoids-Biology, Chemistry and Medicine

1994 • 987 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

Regulation of terminal differentiation of cultured human keratinocytes by vitamin A

1981 • 756 citations

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

1993 • 738 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

1990 • 587 citations

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

1992 • 583 citations

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

1991 • 527 citations

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1994 • 508 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

1989 • 482 citations

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements.

1994 • 470 citations

A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor

1988 • 439 citations

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

1991 • 421 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

1991 • 395 citations

Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

1991 • 390 citations

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.

1992 • 389 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization.

1987 • 343 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

1993 • 305 citations

Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

1990 • 304 citations

Developmental expression of murine retinoid X receptor (RXR) genes

1994 • 297 citations

The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.

1994 • 251 citations

Topical tretinoin for treatment of photodamaged skin. A multicenter study.

1991 • 224 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

Retinoic Acid Receptor Gene Expression in Human Skin

1991 • 212 citations

Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.

1994 • 210 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

Topical Tretinoin (Retinoic Acid) Therapy for Hyperpigmented Lesions Caused by Inflammation of the Skin in Black Patients

1993 • 199 citations

Transactivation properties of retinoic acid and retinoid X receptors in mammalian cells and yeast. Correlation with hormone binding and effects of metabolism.

1993 • 185 citations

Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin.

1994 • 179 citations

Tretinoin emollient cream: A new therapy for photodamaged skin

1992 • 179 citations

Topical Tretinoin for Treatment of Photodamaged Skin

1991 • 174 citations

Topical Tretinoin (Retinoic Acid) Treatment for Liver Spots Associated with Photodamage

1992 • 165 citations

Selective high affinity retinoic acid receptor alpha or beta-gamma ligands.

1991 • 144 citations

The directly repeated RG(G/T)TCA motifs of the rat and mouse cellular retinol-binding protein II genes are promiscuous binding sites for RAR, RXR, HNF-4, and ARP-1 homo- and heterodimers.

1994 • 142 citations

One cell-specific and three ubiquitous nuclear proteins bind in vitro to overlapping motifs in the domain B1 of the SV40 enhancer.

1987 • 127 citations

Retinoic acid receptor gamma: specific immunodetection and phosphorylation.

1991 • 121 citations

Differential Regulation of Retinoic Acid Receptors and Binding Proteins in Human Skin

1992 • 118 citations

Decreased Cyclic AMP in the Epidermis of Lesions of Psoriasis

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Retinoid Receptors

1993 • 88 citations

Selective Synthetic Ligands for Human Nuclear Retinoic Acid Receptors

1992 • 84 citations

Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors

1993 • 83 citations

Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.

1994 • 77 citations

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain.

1994 • 72 citations

RARβ isoforms: distinct transcriptional control by retinoic acid and specific spatial patterns of promoter activity during mouse embryonic development

1994 • 66 citations

Retinoic Acid Receptors and Binding Proteins in Human Skin

1992 • 55 citations

Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha.

1994 • 52 citations

Retinoic acid receptor expression in human skin keratinocytes and dermal fibroblasts in vitro

1992 • 46 citations

Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation.

1992 • 45 citations

Terminal Differentiation in Keratinocytes Involves Positive as Well as Negative Regulation by Retinoic Acid Receptors and Retinoid X Receptors at Retinoid Response Elements

1992 • 41 citations

Hetero- and homodimeric receptors in thyroid hormone and vitamin A action.

1993 • 37 citations

A Pleiotropic Response Is Induced in F9 Embryonal Carcinoma Cells and Rhino Mouse Skin by All-trans-Retinoic Acid, a RAR Agonist but Not by SR11237, a RXR-Selective Agonist

1994 • 29 citations

Constitutively active retinoid receptors exhibit interfamily and intrafamily promoter specificity.

1994 • 24 citations