Structure and Regulation of the Gene Encoding the Neuron-specific Protein Kinase C Substrate Neurogranin (RC3 Protein)

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Axonal Growth-Associated Proteins

1989 • 1,118 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Compilation of vertebrate-encoded transcription factors

1992 • 934 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones.

1986 • 526 citations

Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.

1991 • 519 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

1990 • 426 citations

A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells

1992 • 420 citations

Cloning of Complementary DNA for GAP-43, a Neuronal Growth-Related Protein

1987 • 351 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.

1987 • 328 citations

Silencing the type II sodium channel gene: A model for neural-specific gene regulation

1992 • 315 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.

1990 • 281 citations

Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus amino acid sequence between neurogranin and neuromodulin (GAP43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain.

1991 • 274 citations

Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

1990 • 270 citations

Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate

1990 • 263 citations

Identification and characterization of the calmodulin-binding domain of neuromodulin, a neurospecific calmodulin-binding protein.

1988 • 262 citations

Regulation of free calmodulin levels by neuromodulin: neuron growth and regeneration

1990 • 226 citations

Target regulation of neurotransmitter phenotype

1990 • 221 citations

Tissue distribution and developmental expression of protein kinase C isozymes.

1988 • 215 citations

Mechanisms of complex transcriptional regulation: implications for brain development

1991 • 193 citations

Subtractive cDNA cloning of RC3, a rodent cortex‐enriched mRNA encoding a novel 78 residue protein

1990 • 193 citations

The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer.

1988 • 181 citations

Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene.

1993 • 169 citations

Characterization of the calmodulin binding domain of neuromodulin. Functional significance of serine 41 and phenylalanine 42.

1991 • 165 citations

Identification of the protein kinase C phosphorylation site in neuromodulin

1990 • 164 citations

Localization of the protein kinase C phosphorylation/calmodulin-binding substrate RC3 in dendritic spines of neostriatal neurons.

1992 • 147 citations

The 5'-flanking region of the synapsin I gene. A G+C-rich, TATA- and CAAT-less, phylogenetically conserved sequence with cell type-specific promoter function.

1990 • 125 citations

Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding.

1992 • 124 citations

B-50 phosphorylation and polyphosphoinositide metabolism in nerve growth cone membranes

1988 • 119 citations

A purine-rich DNA sequence motif present in SV40 and lymphotropic papovavirus binds a lymphoid-specific factor and contributes to enhancer activity in lymphoid cells.

1987 • 110 citations

Increased Phosphorylation of a 17‐kDa Protein Kinase C Substrate (P17) in Long‐Term Potentiation

1992 • 104 citations

A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity

1992 • 102 citations

Transcriptional and post-transcriptional regulation of tyrosine hydroxylase gene by protein kinase C.

1990 • 100 citations

Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase-C substrate.

1993 • 99 citations

Phosphoprotein F1: purification and characterization of a brain kinase C substrate related to plasticity

1986 • 99 citations

Characterization of a 7.5-kDa Protein Kinase C Substrate (RC3 Protein, Neurogranin) from Rat Brain

1993 • 91 citations

Characterization of tissue-specific transcription by the human synapsin I gene promoter.

1991 • 87 citations

Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene

1991 • 81 citations

The structure and expression of neuron-specific enolase gene

1987 • 65 citations

Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse

1992 • 64 citations

A bifunctional genetic regulatory element of the rat dopamine beta-hydroxylase gene influences cell type specificity and second messenger-mediated transcription.

1992 • 64 citations

Characterization of Two Atypical Promoters and Alternate mRNA Processing in the Mouse Thy-1.2 Glycoprotein Gene

1986 • 60 citations

Complete structure of the human gene encoding neuron-specific enolase

1991 • 56 citations

Transcription: Mechanism and Regulation

2014 • 42 citations

The brain‐specific gene for rat aldolase C possesses an unusual housekeeping‐type promoter

1989 • 39 citations

Cloning and Characterization of the Rat Gene Encoding GAP‐43

1990 • 39 citations

Characterization of the 5'-flanking region of the rat protein kinase C gamma gene.

1990 • 26 citations

Cell Lineage Segregation during Neural Crest Ontogenya

1990 • 24 citations

Positive- and negative-acting promoter sequences regulate cell type-specific expression of the rat synapsin I gene

1991 • 22 citations

c-mos Upstream sequence exhibits species-specific enhancer activity and binds murine-specific nuclear proteins

1987 • 20 citations

Structure and regulation of the gene encoding the neuron-specific protein PEP-19

1993 • 11 citations

Identification of a nuclear protein binding element within the rat brain protein kinase C γ promoter that is related to the developmental control of this gene

1993 • 7 citations

Preparation of Protein Kinase C Isozymes and Substrates from Rat Brain

1993 • 7 citations