B-cell receptor regulation of peripheral B cells

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

1994 • 541 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

1997 • 505 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells.

1993 • 413 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

Differentiation of lymphocytes in mouse bone marrow

1974 • 305 citations

The changing preference of T and B cells for partners as T‐dependent antibody responses develop

1997 • 292 citations

The site and stage of anti-DNA B-cell deletion

1995 • 283 citations

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

1995 • 274 citations

Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones

1988 • 272 citations

IDENTIFICATION OF MARROW-DERIVED AND THYMUS-DERIVED SMALL LYMPHOCYTES IN THE LYMPHOID TISSUE AND THORACIC DUCT LYMPH OF NORMAL RATS

1972 • 270 citations

Comparative migration of B- and T-lymphocytes in the rat spleen and lymph nodes

1976 • 267 citations

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

1996 • 244 citations

Pre-B cells in mouse bone marrow: immunofluorescence stathmokinetic studies of the proliferation of cytoplasmic mu-chain-bearing cells in normal mice.

1983 • 188 citations

Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype.

1991 • 180 citations

Regulation of Anti–double-stranded DNA B Cells in Nonautoimmune Mice: Localization to the T–B Interface of the Splenic Follicle

1997 • 176 citations

Human IgM⁺IgD⁺ B cells, the major B cell subset in the peripheral blood, express Vϰ genes with no or little somatic mutation throughout life

1993 • 166 citations

Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool

1997 • 163 citations

Migrant μ⁺δ⁺ and static μ⁺δ⁻ B lymphocyte subsets

1982 • 159 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence

1983 • 133 citations

B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn

1993 • 112 citations

Differences in the recruitment of virgin B cells into antibody responses to thymus‐dependent and thymus‐independent type‐2 antigens

1986 • 99 citations

Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse.

1996 • 98 citations

Heavy-chain directed B-cell maturation: continuous clonal selection beginning at the pre-B cell stage

1994 • 85 citations

Lack of mature B cells in nude mice with X-linked immune deficiency.

1982 • 83 citations

Role of Btk in B cell development and signaling

1997 • 81 citations

Newly produced virgin B cells migrate to secondary lymphoid organs but their capacity to enter follicles is restricted

1987 • 75 citations

Outer Periarteriolar Lymphoid Sheath Arrest and Subsequent Differentiation of Both Naive and Tolerant Immunoglobulin Transgenic B Cells Is Determined by B Cell Receptor Occupancy

1997 • 74 citations

Co-receptors of B lymphocytes

1997 • 73 citations

B cell memory to thymus‐independent antigens type 1 and type 2: the role of lipopolysaccharide in B memory induction

1988 • 71 citations

Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40

1997 • 60 citations

Population kinetics of rat peripheral B cells.

1988 • 60 citations

Signaling thresholds and interclonal competition in preimmune B‐cell selection

1997 • 51 citations

Influences on the lifespan of B cell subpopulations defined by different phenotypes

1997 • 50 citations

B-cell production and differentiation in adult rats.

1985 • 46 citations

Development of B lymphocytes in mice heterozygous for the X-linked immunodeficiency (xid) mutation. xid inhibits development of all splenic and lymph node B cells at a stage subsequent to their initial formation in bone marrow.

1987 • 45 citations

Only a small proportion of splenic B cells in adults are short‐lived virgin cells

1993 • 42 citations

The ontogeny and distribution of B cells in normal and mutant immune-defective CBA/N mice: two-parameter analysis of surface IgM and IgD.

1983 • 37 citations

CBA/N Mice have Marginal Zone B Cells with Normal Surface Immunoglobulin Phenotype

1988 • 13 citations