Intraclonal generation of antibody mutants in germinal centres

Sequences of proteins of immunological interest

1984 • 3,427 citations

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

1988 • 814 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

DNA damage promotes jumping between templates during enzymatic amplification.

1990 • 510 citations

Fidelity of DNA polymerases in DNA amplification.

1989 • 487 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Maintenance of B-cell memory by long-lived cells generated from proliferating precursors

1990 • 323 citations

The Role of Somatic Hypermutation in the Generation of Antibody Diversity

1989 • 305 citations

Kinetic maturation of an immune response

1991 • 274 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches

1991 • 269 citations

Peanut lectin binding properties of germinal centers of mouse lymphoid tissue

1980 • 259 citations

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP.

1986 • 227 citations

Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development

1987 • 218 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

Structure of primary anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1985 • 184 citations

Errors in the Polymerase Chain Reaction

1988 • 153 citations

Germinal Center Reaction and B Lymphocytes: Morphology and Function

1990 • 111 citations

Somatic mutations in antibodies expressed by germinal centre B cells early after primary immunization

1990 • 83 citations

A limited number of B cell lineages generates the heterogeneity of a secondary immune response.

1987 • 83 citations

Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.

1989 • 71 citations

Development of B cell lineages during a primary anti-hapten immune response.

1990 • 27 citations