Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Myeloid-derived suppressor cells as regulators of the immune system

2009 • 6,165 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

2008 • 1,304 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

2002 • 1,169 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

2009 • 923 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine

2009 • 836 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

2005 • 741 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

Mechanisms of Immune Evasion by Tumors

2006 • 665 citations

Interleukin-12 in anti-tumor immunity and immunotherapy

2002 • 663 citations

Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells

2008 • 597 citations

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

2007 • 510 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

2010 • 421 citations

Adoptively transferred effector cells derived from naïve rather than central memory CD8 ⁺ T cells mediate superior antitumor immunity

2009 • 363 citations

In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor

2007 • 362 citations

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

2007 • 353 citations

Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation

2006 • 323 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

1996 • 311 citations

The Anti-Tumor Activity of IL-12: Mechanisms of Innate Immunity That Are Model and Dose Dependent

2000 • 304 citations

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

1995 • 277 citations

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

2008 • 275 citations

Interleukin-12 Therapy of Cutaneous T-Cell Lymphoma Induces Lesion Regression and Cytotoxic T-Cell Responses

1999 • 272 citations

Increased Intensity Lymphodepletion Enhances Tumor Treatment Efficacy of Adoptively Transferred Tumor-specific T Cells

2009 • 265 citations

Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions

2005 • 229 citations

Immunotherapy of cancer by IL-12-based cytokine combinations

2007 • 215 citations

Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts.

1995 • 206 citations

Intratumoral Injection of Dendritic Cells Engineered to Secrete Interleukin-12 by Recombinant Adenovirus in Patients With Metastatic Gastrointestinal Carcinomas

2004 • 176 citations

IL-12 Inhibition of Endothelial Cell Functions and Angiogenesis Depends on Lymphocyte-Endothelial Cell Cross-Talk

2001 • 148 citations

Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

1997 • 146 citations

Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity.

2003 • 135 citations

Interleukin 12 Gene Therapy of Cancer by Peritumoral Injection of Transduced Autologous Fibroblasts: Outcome of a Phase I Study

2001 • 134 citations

Intratumoral Recombinant Human Interleukin-12 Administration in Head and Neck Squamous Cell Carcinoma Patients Modifies Locoregional Lymph Node Architecture and Induces Natural Killer Cell Infiltration in the Primary Tumor

2005 • 89 citations

Genetic Modification of T Lymphocytes for Adoptive Immunotherapy

2004 • 86 citations

A strategy for treatment of Epstein–Barr virus-positive Hodgkin's disease by targeting interleukin 12 to the tumor environment using tumor antigen-specific T cells

2003 • 78 citations

Interleukin-12 as an Adjuvant for Cancer Immunotherapy

1999 • 70 citations

Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression.

1998 • 65 citations

Construction and Biological Characterization of an Interleukin-12 Fusion Protein (Flexi-12): Delivery to Acute Myeloid Leukemic Blasts Using Adeno-Associated Virus

1997 • 63 citations

IL-12 Regulates an Endothelial Cell-Lymphocyte Network: Effect on Metalloproteinase-9 Production

2003 • 56 citations

IL-12/IL-2 combination cytokine therapy for solid tumours: translation from bench to bedside

2002 • 52 citations

IL-12 Enhances CTL Synapse Formation and Induces Self-Reactivity

2009 • 30 citations

Autologous and MHC class I–negative allogeneic tumor cells secreting IL-12 together cure disseminated A20 lymphoma

2002 • 22 citations