Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance

2004 • 2,910 citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

2003 • 2,064 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor Eomesodermin

2003 • 956 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Central memory self/tumor-reactive CD8 ⁺ T cells confer superior antitumor immunity compared with effector memory T cells

2005 • 878 citations

Adoptive immunotherapy for cancer: building on success

2006 • 848 citations

Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

2007 • 824 citations

Target genes of β-catenin–T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

1999 • 807 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Pharmacological inhibitors of glycogen synthase kinase 3

2004 • 577 citations

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

2007 • 567 citations

WNT signalling in the immune system: WNT is spreading its wings

2008 • 539 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

2008 • 485 citations

CD8⁺ T‐cell memory in tumor immunology and immunotherapy

2006 • 472 citations

β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

2001 • 457 citations

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

1999 • 452 citations

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

2008 • 435 citations

CD8+ T cell efficacy in vaccination and disease

2008 • 368 citations

Synthetic small molecules that control stem cell fate

2003 • 365 citations

Host-reactive CD8+ memory stem cells in graft-versus-host disease

2005 • 348 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

Arrested Differentiation, the Self-Renewing Memory Lymphocyte, and Vaccination

2001 • 264 citations

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells

2006 • 263 citations

Critical Involvement of Tcf-1 in Expansion of Thymocytes

1998 • 238 citations

Long-term, multilineage hematopoiesis occurs in the combined absence of β-catenin and γ-catenin

2007 • 213 citations

Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8+ T cells

2007 • 201 citations

Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases

2006 • 194 citations

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

2008 • 185 citations

Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-1) following Antigen Encounter In Vitro and In Vivo

2006 • 180 citations

Rapid Culling of the CD4+ T Cell Repertoire in the Transition from Effector to Memory

2008 • 170 citations

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3

2000 • 162 citations

Two βs or not two βs: regulation of asymmetric division by β-catenin

2007 • 119 citations

Nemo is an inducible antagonist of Wingless signaling duringDrosophilawing development

2004 • 57 citations

Comparative integromics on FZD7 orthologs: Conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs

2007 • 24 citations