Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

2006 • 2,500 citations

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

2009 • 1,347 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 • 1,173 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

2005 • 916 citations

Adoptive immunotherapy for cancer: building on success

2006 • 848 citations

Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells

2001 • 759 citations

Enhanced Antitumor Activity of Murine-Human Hybrid T-Cell Receptor (TCR) in Human Lymphocytes Is Associated with Improved Pairing and TCR/CD3 Stability

2006 • 437 citations

Facilitating matched pairing and expression of TCR chains introduced into human T cells

2006 • 352 citations

Enhanced Antitumor Activity of T Cells Engineered to Express T-Cell Receptors with a Second Disulfide Bond

2007 • 345 citations

Telomere Length of Transferred Lymphocytes Correlates with In Vivo Persistence and Tumor Regression in Melanoma Patients Receiving Cell Transfer Therapy

2005 • 331 citations

Immunotherapy through TCR gene transfer

2001 • 287 citations

T-cell-receptor gene therapy

2002 • 266 citations

Tolerance to p53 by A2.1-restricted Cytotoxic T Lymphocytes

1997 • 264 citations

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

2008 • 238 citations

Reprogramming of Virus-specific T Cells into Leukemia-reactive T Cells Using T Cell Receptor Gene Transfer

2004 • 194 citations

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR

2000 • 171 citations

IL-7 and IL-15 allow the generation of suicide gene–modified alloreactive self-renewing central memory human T lymphocytes

2008 • 157 citations

Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model.

2000 • 127 citations

Transfusion-Associated Graft-Versus-Host Disease

2018 • 105 citations

Selecting highly affine and well-expressed TCRs for gene therapy of melanoma

2007 • 104 citations

Transfusion-associated graft-versus-host disease: historical perspectives, incidence, and current use of irradiated blood products.

1991 • 100 citations

A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection

2005 • 98 citations

A mouse model of lymphocyte infusion-induced bone marrow failure

2004 • 97 citations

A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer

2008 • 95 citations

Molecular Design of the Cαβ Interface Favors Specific Pairing of Introduced TCRαβ in Human T Cells

2008 • 94 citations

Targeting the Wilms Tumor Antigen 1 by TCR Gene Transfer: TCR Variants Improve Tetramer Binding but Not the Function of Gene Modified Human T Cells

2007 • 78 citations

Human TCR That Incorporate CD3ζ Induce Highly Preferred Pairing between TCRα and β Chains following Gene Transfer

2008 • 77 citations

Targeting self-antigens through allogeneic TCR gene transfer

2006 • 74 citations

Opposing Effects of IL-2 in Tumor Immunotherapy: Promoting CD8 T Cell Growth and Inducing Apoptosis

2002 • 66 citations

Transfusion‐associated graft‐versus‐host disease in immunocompetent patients: case series and review of the literature

2007 • 66 citations

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008

2009 • 58 citations

Requirements for Effective Antitumor Responses of TCR Transduced T Cells

2008 • 55 citations

Generation of T Cell Help through a MHC Class I-Restricted TCR

2006 • 50 citations

Preclinical development of T cell receptor gene therapy

2009 • 48 citations

TCR Gene Therapy of Spontaneous Prostate Carcinoma Requires In Vivo T Cell Activation

2008 • 44 citations

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure

2009 • 38 citations

Passive but not active CD8+ T cell-based immunotherapy interferes with liver tumor progression in a transgenic mouse model.

1998 • 38 citations

Cutting Edge: Passive But Not Active CD8+ T Cell-Based Immunotherapy Interferes with Liver Tumor Progression in a Transgenic Mouse Model

1998 • 29 citations

Dual T Cell Receptor Expressing CD8+ T Cells with Tumor- and Self-Specificity Can Inhibit Tumor Growth without Causing Severe Autoimmunity

2007 • 24 citations

Biodistribution and Retention Time of Retrovirally Labeled T Lymphocytes in Mice is Strongly Influenced by the Culture Period Before Infusion

2002 • 11 citations