Intratumoral Recombinant Human Interleukin-12 Administration in Head and Neck Squamous Cell Carcinoma Patients Modifies Locoregional Lymph Node Architecture and Induces Natural Killer Cell Infiltration in the Primary Tumor

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses

2000 • 1,665 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Interleukin-12 in anti-tumor immunity and immunotherapy

2002 • 663 citations

DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking

2000 • 498 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

The intriguing role of polymorphonuclear neutrophils in antitumor reactions

2001 • 411 citations

A Novel Lysosome-Associated Membrane Glycoprotein, DC-LAMP, Induced upon DC Maturation, Is Transiently Expressed in MHC Class II Compartment

1998 • 402 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

Interleukin-12

1994 • 285 citations

Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response.

2000 • 274 citations

Phase I trial of subcutaneous recombinant human interleukin-12 in patients with advanced renal cell carcinoma.

1998 • 219 citations

Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma.

2002 • 214 citations

Immunological effects of interleukin 12 administered by bolus intravenous injection to patients with cancer.

1999 • 173 citations

Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma

2003 • 170 citations

Mast cells, basophils, and eosinophils: distinct but overlapping pathways for recruitment

2001 • 169 citations

Pilot study of subcutaneous recombinant human interleukin 12 in metastatic melanoma.

1998 • 160 citations

Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas.

2003 • 155 citations

Where have all the T cells gone? Mechanisms of immune evasion by tumors

1999 • 153 citations

Phase 1 study of interleukin-12 in combination with rituximab in patients with B-cell non-Hodgkin lymphoma

2002 • 147 citations

Randomized Multicenter Phase II Trial of Subcutaneous Recombinant Human Interleukin-12 Versus Interferon-α2a for Patients with Advanced Renal Cell Carcinoma

2001 • 113 citations

Phase I study of subcutaneously administered recombinant human interleukin 12 in patients with advanced renal cell cancer.

1999 • 108 citations

In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment

2003 • 104 citations

Evaluation of Recombinant Human Interleukin-12 in Patients with Recurrent or Refractory Ovarian Cancer: A Gynecologic Oncology Group Study

2001 • 95 citations

Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8+ T cells in melanoma patients receiving interleukin 12.

2000 • 95 citations

Interleukin 12: a new clinical player in cytokine therapy

1995 • 83 citations

Intratumoral Administration of Recombinant Human Interleukin 12 in Head and Neck Squamous Cell Carcinoma Patients Elicits a T-Helper 1 Profile in the Locoregional Lymph Nodes

2004 • 78 citations

Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.

2002 • 74 citations

IL-12-Activated NK Cells Reduce Lung Eosinophilia to the Attachment Protein of Respiratory Syncytial Virus But Do Not Enhance the Severity of Illness in CD8 T Cell-Immunodeficient Conditions

2000 • 72 citations

The Role for Interleukin‐12 Therapy of Cutaneous T Cell Lymphoma

2001 • 58 citations

Interleukin-12 Stimulates B Cell Growth by Inducing IFN-γ

1996 • 51 citations

Pharmacokinetics and immunological aspects of a phase Ib study with intratumoral administration of recombinant human interleukin-12 in patients with head and neck squamous cell carcinoma: a decrease of T-bet in peripheral blood mononuclear cells.

2003 • 49 citations

Antitumor effects of cytolytic T lymphocytes (CTL) and natural killer (NK) cells in head and neck cancer.

1996 • 44 citations

Evidence for involvement of B lymphocytes in the surveillance of lung metastasis in the rat.

1999 • 35 citations

Phase I study of interleukin-12 in combination with Rituximab in patients with B-cell non-Hodgkin lymphoma

2001 • 18 citations