Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

1993 • 945 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major

1994 • 687 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Th1 and Th2 subsets: paradigms lost?

1995 • 482 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

1994 • 435 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Restoration of HIV-Specific Cell-Mediated Immune Responses by Interleukin-12 in Vitro

1993 • 397 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.

1994 • 367 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity.

1983 • 351 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

1994 • 305 citations

Effects of IL-12 on helper T cell-dependent immune responses in vivo.

1994 • 294 citations

Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T_H1 Cells

1995 • 292 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.

1994 • 281 citations

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

1993 • 265 citations

Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (T_h1) but not on T_h2 cells

1993 • 241 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1971 • 230 citations

CD8+ T cells can be primed in vitro to produce IL-4.

1992 • 214 citations

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

1992 • 198 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1972 • 196 citations

Differential regulation of interleukin-12 (IL-12), tumor necrosis factor alpha, and IL-1 beta production in human myeloid leukemia cell lines and peripheral blood mononuclear cells

1994 • 182 citations

Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.

1995 • 168 citations

IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes.

1995 • 144 citations

Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major.

1994 • 137 citations

Differential effects of interleukin‐12 on the development of naive mouse CD4⁺ T cells

1994 • 132 citations

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.

1995 • 131 citations

Gamma interferon and lymphotoxin, released by activated T cells, synergize to inhibit granulocyte/monocyte colony formation.

1986 • 130 citations

High level of interleukin-10 production by the activated t cell population within the rheumatoid synovial membrane

1995 • 121 citations

Evidence for the stochastic acquisition of cytokine profile by CD4⁺ T cells activated in a T helper type 2‐like response in vivo

1995 • 98 citations

HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite-induced monokines.

1995 • 93 citations

Are CD4⁺ T_h1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-_γ or IL-2 determines their function

1995 • 86 citations

In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12.

1994 • 75 citations

IL-12 transiently induces IFN-_γ transcription and protein synthesis in human CD4 ⁺ allergen-specific T_h2 T cell clones

1994 • 68 citations

Limit-dilution assay and clonal expansion of all T cells capable of proliferation

1982 • 53 citations

Development of human Th1 and Th2 cytokine responses: The cytokine production profile of T cells is dictated by the primary in vitro stimulus

1993 • 50 citations

Priming for high interferon-gamma production induced by interleukin-12 in both CD4+ and CD8+ T cell clones from HIV-infected patients.

1995 • 39 citations

Production of inflammatory cytokines in the intestinal lamina propria

1991 • 31 citations

Deleted Work

1955 • 0 citations