Molecular mechanisms of neurodegeneration in Alzheimer's disease

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

The Ki-67 protein: From the known and the unknown

2000 • 4,426 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

2008 • 3,404 citations

Mechanisms and Functional Implications of Adult Neurogenesis

2008 • 2,904 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

2007 • 1,795 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Purification and cloning of amyloid precursor protein β-secretase from human brain

1999 • 1,589 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

APP Processing and Synaptic Function

2003 • 1,575 citations

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

2007 • 1,501 citations

Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease

2007 • 1,498 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

The Role of Apolipoprotein E in Alzheimer's Disease

2009 • 1,475 citations

Wnt signalling regulates adult hippocampal neurogenesis

2005 • 1,460 citations

Amyloid pores from pathogenic mutations

2002 • 1,260 citations

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

2001 • 1,032 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

A decade of CDK5

2001 • 1,027 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

2001 • 988 citations

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

2006 • 982 citations

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

2001 • 975 citations

Increased hippocampal neurogenesis in Alzheimer's disease

2003 • 955 citations

Notch signalling regulates stem cell numbers in vitro and in vivo

2006 • 943 citations

Tau in Alzheimer's disease

1998 • 936 citations

Metabolic Regulation of Brain Aβ by Neprilysin

2001 • 918 citations

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 • 915 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

2009 • 874 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

2003 • 788 citations

Alzheimer's Disease

1986 • 772 citations

Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

2009 • 768 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

Multipotent progenitor cells in the adult dentate gyrus

1998 • 722 citations

Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides

2005 • 716 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

2001 • 675 citations

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

2003 • 664 citations

2010 Alzheimer's disease facts and figures

2010 • 662 citations

Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

2004 • 638 citations

Axonal Self-Destruction and Neurodegeneration

2002 • 632 citations

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

2001 • 617 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways

2006 • 559 citations

Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease

1999 • 554 citations

Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets

2002 • 533 citations

A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

2005 • 512 citations

New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment

2005 • 500 citations

-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

2009 • 498 citations

Amyloid-β oligomers: their production, toxicity and therapeutic inhibition

2002 • 491 citations

The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain

2000 • 479 citations

Laying it on thick

1999 • 471 citations

Vesicle Permeabilization by Protofibrillar α-Synuclein Is Sensitive to Parkinson's Disease-Linked Mutations and Occurs by a Pore-like Mechanism

2002 • 470 citations

Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

2002 • 460 citations

Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

1997 • 459 citations

Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APP _Sw,Ind ) mice

2004 • 432 citations

Oligomers on the Brain: the Emerging Role of Soluble Protein Aggregates in Neurodegeneration.

2004 • 429 citations

Glycogen synthase kinase 3: a drug target for CNS therapies

2004 • 415 citations

Activation and redistribution of c‐Jun N‐terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

2001 • 412 citations

Role of microtubule-associated proteins in the control of microtubule assembly

1995 • 396 citations

Structural Correlates of Cognition in Dementia: Quantification and Assessment of Synapse Change

1996 • 387 citations

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

2005 • 374 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease

2002 • 371 citations

The presenilins and Alzheimer's disease

1997 • 364 citations

Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease

2006 • 355 citations

Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

1999 • 353 citations

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

2000 • 336 citations

Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress

2004 • 331 citations

Glycogen synthase kinase‐3 inhibition is integral to long‐term potentiation

2007 • 322 citations

Neurogenesis and Alzheimer's disease: At the crossroads

2009 • 321 citations

Patterns of gliosis in alzheimer's disease and aging cerebrum

1989 • 318 citations

Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex

1998 • 315 citations

Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus

2006 • 312 citations

Causative and susceptibility genes for Alzheimer’s disease: a review

2003 • 310 citations

Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease

2005 • 305 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Opposing Roles of Transient and Prolonged Expression of p25 in Synaptic Plasticity and Hippocampus-Dependent Memory

2005 • 281 citations

Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3β Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein Phosphorylation

2007 • 275 citations

Mechanisms of Neuronal Death in Alzheimer's Disease

1996 • 267 citations

Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.

1996 • 259 citations

Role of the β‐amyloid protein in Alzheimer's disease

1995 • 258 citations

The Molecular Basis of Memantine Action in Alzheimers Disease and Other Neurologic Disorders: Low-affinity, Uncompetitive Antagonism

2005 • 249 citations

The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Proteina

1996 • 244 citations

Site-specific Phosphorylation of Synapsin I by Mitogen-activated Protein Kinase and Cdk5 and Its Effects on Physiological Functions

1996 • 243 citations

Disruption of Neurogenesis in the Subventricular Zone of Adult Mice,and in Human Cortical Neuronal Precursor Cells in Culture, by Amyloid β-Peptideby Amyloid β-Peptide

2002 • 239 citations

Synaptic Changes in Alzheimer's Disease

2004 • 239 citations

Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus

2008 • 227 citations

Memory Dysfunction

2005 • 227 citations

Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment

2007 • 224 citations

Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease

2006 • 224 citations

<I>APOE</I> Genotype Effects on Alzheimer's Disease Onset and Epidemiology

2004 • 220 citations

Early formation of mature amyloid‐β protein deposits in a mutant APP transgenic model depends on levels of Aβ_1–42

2001 • 218 citations

p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid βIn Vivo

2006 • 202 citations

Notch and Neurogenesis

2018 • 200 citations

Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar Aβ

2006 • 187 citations

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

2004 • 183 citations

“Fatal Attractions” of Proteins: A Comprehensive Hypothetical Mechanism Underlying Alzheimer's Disease and Other Neurodegenerative Disorders

2000 • 181 citations

Cell death: protein misfolding and neurodegenerative diseases

2009 • 176 citations

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

2004 • 169 citations

A 24-week Randomized, Controlled Trial of Memantine in Patients With Moderate-to-severe Alzheimer Disease

2007 • 168 citations

Correlation between Caspase Activation and Neurofibrillary Tangle Formation in Alzheimer’s Disease

2001 • 167 citations

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain

1999 • 165 citations

Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice

2004 • 163 citations

Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5.

1997 • 157 citations

Cyclin-Dependent Kinase 5 Is Essential for Neuronal Cell Cycle Arrest and Differentiation

2005 • 154 citations

Amyloid β protein precursor and the pathogenesis of Alzheimer's disease

1989 • 149 citations

Decreased levels of PSD95 and two associated proteins and increased levels of BCl₂ and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

2009 • 149 citations

Lysosomal Activation Is a Compensatory Response Against Protein Accumulation and Associated Synaptopathogenesis—An Approach for Slowing Alzheimer Disease?

2003 • 146 citations

Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease

1998 • 146 citations

Molecular genetics of Alzheimer's disease

1998 • 145 citations

Perturbed Neurogenesis in the Adult Hippocampus Associated with Presenilin-1 A246E Mutation

2005 • 144 citations

Cyclin‐dependent kinase‐5 in neurodegeneration

2004 • 144 citations

Cdk5 Regulates the Organization of Nestin and Its Association with p35

2003 • 143 citations

Alzheimer's APP mangles mitochondria

2006 • 138 citations

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons

1997 • 131 citations

p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis

2008 • 130 citations

Cdk5 Regulates Accurate Maturation of Newborn Granule Cells in the Adult Hippocampus

2008 • 121 citations

Cyclin-Dependent Kinase 5 Mediates Neurotoxin-Induced Degradation of the Transcription Factor Myocyte Enhancer Factor 2

2005 • 118 citations

Cdk5 is essential for adult hippocampal neurogenesis

2008 • 115 citations

Cdk5 on the brain.

2001 • 105 citations

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

1991 • 105 citations

Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5

2003 • 105 citations

Evidence of Aβ‐ and transgene‐dependent defects in ERK‐CREB signaling in Alzheimer’s models

2007 • 104 citations

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Aβ levels

2008 • 103 citations

APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis

2009 • 101 citations

Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer’s and Parkinson’s diseases

2010 • 98 citations

Effects of Cerebrolysin™ on neurogenesis in an APP transgenic model of Alzheimer’s disease

2006 • 96 citations

Expression of APP in transgenic mice: a Comparison of neuron-specific promoters

1996 • 94 citations

Astroglial Activation of Extracellular-Regulated Kinase in Early Stages of Alzheimer Disease

2006 • 89 citations

Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role

2004 • 89 citations

Cerebrolysin decreases amyloid‐β production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease

2006 • 84 citations

The neuroprotective effects of Cerebrolysin? in a transgenic model of Alzheimer?s disease are associated with improved behavioral performance

2003 • 80 citations

Disassembly of Shank and Homer Synaptic Clusters Is Driven by Soluble β-Amyloid1-40 through Divergent NMDAR-Dependent Signalling Pathways

2009 • 79 citations

State-specific projections through 2025 of Alzheimer disease prevalence

2004 • 77 citations

Stabilization of the cyclin‐dependent kinase 5 activator, p35, by paclitaxel decreases β‐amyloid toxicity in cortical neurons

2003 • 73 citations

Intracellular and Extracellular Aβ, a Tale of Two Neuropathologies

2006 • 72 citations

Glycogen synthase kinase 3 alteration in alzheimer disease is related to neurofibrillary tangle formation

1996 • 71 citations

Molecular genetics of Alzheimer’s disease

2004 • 71 citations

Calcium‐Activated Neutral Proteinases as Regulators of Cellular Function Implications for Alzheimer's Disease Pathogenesis^a

1989 • 68 citations

Interaction of Neuronal Cdc2-like Protein Kinase with Microtubule-associated Protein Tau

2000 • 66 citations

Alzheimer's disease-related synapse loss in the cingulate cortex

2001 • 66 citations

Memory dysfunction in clinical practice.

2005 • 65 citations

Distribution, levels, and activation of MEK1 in Alzheimer's disease

2003 • 63 citations

Regulation of phosphorylation of tau by cyclin‐dependent kinase 5 and glycogen synthase kinase‐3 at substrate level

2006 • 62 citations

Cyclin-Dependent Kinase 5 Is Required for Control of Neuroblast Migration in the Postnatal Subventricular Zone

2007 • 59 citations

Recent advances in the understanding of the role of synaptic proteins in Alzheimer's Disease and other neurodegenerative disorders

2001 • 58 citations

Neurodegenerative Alzheimer-like Pathology in PDAPP 717V → F Transgenic Mice

1997 • 52 citations

The Value of Transgenic Models for the Study of Neurodegenerative Diseases

2000 • 52 citations

beta-Secretase, APP and Abeta in Alzheimer's disease.

2005 • 52 citations

β-Secretase, APP and Aβ in Alzheimer’s Disease

2006 • 51 citations

Chasing genes in Alzheimer?s and Parkinson?s disease

2004 • 49 citations

Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease

2002 • 48 citations

Amino-terminal region of the β-amyloid precursor protein activates mitogen-activated protein kinase

1995 • 42 citations

The Role of Synaptic Proteins in Alzheimer's Disease

2000 • 40 citations

Aβ peptide enhances focal adhesion kinase/Fyn association in a rat CNS nerve cell line

1996 • 37 citations

Connections, Cognition and Alzheimerʼs Disease

1998 • 36 citations

Molecular Mechanisms of Synaptic Disconnection in Alzheimer’s Disease

1997 • 19 citations

Staying Connected

2004 • 18 citations

Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses

2005 • 17 citations

Recent Advances in the Understanding of the Processing of APP to Beta Amyloid Peptide

2000 • 16 citations

Cellular Signaling Pathways and Cytoskeletal Organization

1996 • 10 citations

Deleted Work

1955 • 0 citations