Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Principles of CDK regulation

1995 • 3,267 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

A decade of CDK5

2001 • 1,027 citations

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 • 915 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1998 • 403 citations

p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment

2001 • 379 citations

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

2001 • 316 citations

Cdk5 is essential for synaptic vesicle endocytosis

2003 • 301 citations

Cyclin dependent kinase regulation

1995 • 286 citations

Modulation of Synapse Formation by Cyclic Adenosine Monophosphate

1983 • 282 citations

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

2004 • 269 citations

Synapse formation between clonal neuroblastoma X glioma hybrid cells and striated muscle cells.

1976 • 252 citations

Site-specific Phosphorylation of Synapsin I by Mitogen-activated Protein Kinase and Cdk5 and Its Effects on Physiological Functions

1996 • 243 citations

Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma X glioma hybrid NG108-15 cells.

1984 • 212 citations

Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles

2003 • 195 citations

α2-Chimaerin, Cyclin-Dependent Kinase 5/p35, and Its Target Collapsin Response Mediator Protein-2 Are Essential Components in Semaphorin 3A-Induced Growth-Cone Collapse

2004 • 195 citations

Evidence for the Participation of the Neuron-Specific CDK5 Activator P35 during Laminin-Enhanced Axonal Growth

1998 • 193 citations

Regulation of Exocytosis by Cyclin-dependent Kinase 5 via Phosphorylation of Munc18

1999 • 191 citations

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

2000 • 185 citations

Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses

2004 • 181 citations

Dihydropyridine‐sensitive and omega‐conotoxin‐sensitive calcium channels in a mammalian neuroblastoma‐glioma cell line.

1992 • 181 citations

Induction of formation of presynaptic terminals in neuroblastoma cells by synapsin IIb

1991 • 179 citations

Regulation of N-cadherin-mediated adhesion by the p35–Cdk5 kinase

2000 • 177 citations

Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

2001 • 171 citations

Regulation of Munc-18/Syntaxin 1A Interaction by Cyclin-dependent Kinase 5 in Nerve Endings

1998 • 160 citations

Cdk5 behind the wheel: a role in trafficking and transport?

2002 • 159 citations

Phosphorylation of Pak1 by the p35/Cdk5 Kinase Affects Neuronal Morphology

2001 • 146 citations

Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum

2004 • 129 citations

Target-Derived GFRα1 as an Attractive Guidance Signal for Developing Sensory and Sympathetic Axons via Activation of Cdk5

2002 • 124 citations

MAP1B Is Required for Netrin 1 Signaling in Neuronal Migration and Axonal Guidance

2004 • 120 citations

Integrin α₁β₁-Mediated Activation of Cyclin-Dependent Kinase 5 Activity Is Involved in Neurite Outgrowth and Human Neurofilament Protein H Lys-Ser-Pro Tail Domain Phosphorylation

2000 • 112 citations

Cdk5 on the brain.

2001 • 105 citations

α6 Integrin Is Regulated with Lens Cell Differentiation by Linkage to the Cytoskeleton and Isoform Switching

1999 • 96 citations

Cyclin-dependent Kinase 5 Promotes Insulin Exocytosis

2001 • 89 citations

Trans-Golgi network delivery of synaptic proteins in synaptogenesis

2003 • 83 citations

Tau Phosphorylation by Cyclin-dependent Kinase 5/p39 during Brain Development Reduces Its Affinity for Microtubules

2003 • 83 citations

Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons

2004 • 79 citations

The Cdk5‐p35 kinase associates with the Golgi apparatus and regulates membrane traffic

2001 • 78 citations

Cyclin-dependent Kinase 5 Associated with p39 Promotes Munc18-1 Phosphorylation and Ca2+-dependent Exocytosis

2004 • 74 citations

Role of Cyclins in Neuronal Differentiation of Immortalized Hippocampal Cells

1997 • 71 citations

p35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule-Associated Protein 1b Distribution in Neurons

2004 • 67 citations

Presynaptic terminal differentiation: transport and assembly

2004 • 67 citations

Signal transduction cascades underlying de novo protein synthesis required for neuronal morphogenesis in differentiating neurons

2004 • 60 citations

Cdk5 and Trio modulate endocrine cell exocytosis

2004 • 57 citations

On the specificity of synapse formation.

1976 • 55 citations

Proliferation and synapse formation of neuroblastoma × glioma hybrid cells: Effect of glia maturation factor

1981 • 53 citations

Overexpression of rat neuronal calcium sensor‐1 in rodent NG108‐15 cells enhances synapse formation and transmission

2001 • 53 citations

Localization and developmental changes in the neuron-specific cyclin-dependent kinase 5 activator (p35nck5a) in the rat brain

1996 • 53 citations

Regulation of the Fusion Pore Conductance during Exocytosis by Cyclin-dependent Kinase 5

2004 • 47 citations

Acetylcholine release by bradykinin, inositol 1,4,5‐trisphosphate and phorbol dibutyrate in rodent neuroblastoma cells.

1988 • 45 citations

Voltage‐Sensitive Calcium Channels in Differentiated Neuroblastoma × Glioma Hybrid (NG108–15) Cells: Characterization by Quin 2 Fluorescence

1988 • 44 citations

Cdk5 in Neuroskeletal Dynamics

2003 • 44 citations

Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock

2001 • 39 citations

Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor

2005 • 29 citations

Expression of Cdk5 and its activators in NT2 cells during neuronal differentiation

2002 • 26 citations

Increase in the expression of the neuronal cyclin-dependent protein kinase cdk-5 during differentiation of N2A neuroblastoma cells

2000 • 23 citations

Expression and Activity of Cyclin-Dependent Kinases and Glycogen Synthase Kinase-3 during NT2 Neuronal Differentiation

2004 • 15 citations

Dissection of bradykinin-evoked responses by buffering intracellular Ca2+ in neuroblastoma × glioma hybrid NG108-15 cells

1992 • 14 citations

Overexpression of rat synapsins in NG108-15 neuronal cells enhances functional synapse formation with myotubes

1999 • 14 citations

Overexpression of Adhesion Molecule L1 in NG108‐15 Neuroblastoma × Glioma Hybrid Cells Enhances Dibutyryl Cyclic AMP‐Induced Neurite Outgrowth and Functional Synapse Formation with Myotubes

1997 • 12 citations

Differential sorting of SNAP-25a and SNAP-25b proteins in neuroblastoma cells

2000 • 10 citations