Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Purification and cloning of amyloid precursor protein β-secretase from human brain

1999 • 1,589 citations

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

1999 • 1,440 citations

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1999 • 1,072 citations

Laying it on thick

1999 • 471 citations

The Presenilins in Alzheimer's Disease--Proteolysis Holds the Key

1999 • 395 citations

BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

2000 • 389 citations

Expression Analysis of BACE2 in Brain and Peripheral Tissues

2000 • 305 citations

Aβ-Generating Enzymes

2000 • 298 citations

The role of Aβ42 in Alzheimer's disease

1998 • 272 citations

Generation and Regulation of β‐Amyloid Peptide Variants by Neurons

1998 • 123 citations

BACE Maps to Chromosome 11 and a BACE Homolog, BACE2 , Reside in the Obligate Down Syndrome Region of Chromosome 21

1999 • 117 citations

Function and Dysfunction of the Presenilins

1999 • 75 citations