Impact of p53 knockout and topotecan treatment on gene expression profiles in human colon carcinoma cells: a pharmacogenomic study.

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles

2001 • 1,555 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

A gene expression database for the molecular pharmacology of cancer

2000 • 1,447 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Heat-shock protein 70 antagonizes apoptosis-inducing factor

2001 • 846 citations

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

2000 • 650 citations

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

2000 • 643 citations

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

1998 • 537 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Identification and classification of p53-regulated genes

1999 • 460 citations

AP-1: One Switch for Many Signals

1999 • 386 citations

Phosphorylation of Bid by Casein Kinases I and II Regulates Its Cleavage by Caspase 8

2001 • 341 citations

DNA microarrays identification of primary and secondary target genes regulated by p53

2001 • 332 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Endoglin modulates cellular responses to TGF-beta 1.

1996 • 306 citations

Tumor Suppressor p53 Protein Is a New Target for the Metastasis-associated Mts1/S100A4 Protein

2001 • 282 citations

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.

1997 • 241 citations

CD105 antagonizes the inhibitory signaling of transforming growth factor βl on human vascular endothelial cells

2000 • 232 citations

Topotecan – A Novel Topoisomerase I Inhibitor: Pharmacology and Clinical Experience

1999 • 199 citations

Regulation of p53 stability and activity in response to genotoxic stress

2000 • 186 citations

Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches

2001 • 166 citations

Metastasis-associated Mts1 (S100A4) Protein Modulates Protein Kinase C Phosphorylation of the Heavy Chain of Nonmuscle Myosin

1998 • 130 citations

Liprin β1, a Member of the Family of LAR Transmembrane Tyrosine Phosphatase-interacting Proteins, Is a New Target for the Metastasis-associated Protein S100A4 (Mts1)

2002 • 124 citations

p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

2001 • 111 citations

Calcium and S100B Regulation of p53-Dependent Cell Growth Arrest and Apoptosis

1998 • 104 citations

S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis.

1998 • 104 citations

Development of a prostate cDNA microarray and statistical gene expression analysis package

2000 • 100 citations

Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: Transgenic rescue and interactions with gene background

1998 • 66 citations

The ARG Tyrosine Kinase Interacts with Siva-1 in the Apoptotic Response to Oxidative Stress

2001 • 66 citations

Calmodulin and Cyclin D Anchoring Sites on the Src-Suppressed C Kinase Substrate, SSeCKS

2002 • 52 citations