Inhibitors of Cytokine Signal Transduction

STATs and Gene Regulation

1997 • 3,927 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

SOCS3 negatively regulates IL-6 signaling in vivo

2003 • 817 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

2003 • 764 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Sumo, ubiquitin's mysterious cousin

2001 • 749 citations

An E3-like Factor that Promotes SUMO Conjugation to the Yeast Septins

2001 • 642 citations

Suppressors of cytokine signalling (SOCS) in the immune system

2002 • 633 citations

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1999 • 620 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer

1997 • 543 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

SOCS: physiological suppressors of cytokine signaling

2000 • 457 citations

SOCS3 regulates the plasticity of gp130 signaling

2003 • 433 citations

The SOCS box: a tale of destruction and degradation

2002 • 409 citations

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130

2000 • 393 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

A superfamily of protein tags: ubiquitin, SUMO and related modifiers

2003 • 367 citations

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1995 • 346 citations

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

2000 • 320 citations

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

2001 • 304 citations

Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

1996 • 291 citations

Guidebook to Cytokines and Their Receptors

1995 • 273 citations

Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.

1993 • 267 citations

Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

2002 • 262 citations

Mutational switch of an IL-6 response to an interferon-γ-like response

2002 • 262 citations

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

2001 • 242 citations

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

2001 • 198 citations

Motheaten, an Immunodeficient Mutant of the Mouse: I. Genetics and pathology

1975 • 198 citations

Preferential Interaction of Sentrin with a Ubiquitin-conjugating Enzyme, Ubc9

1997 • 190 citations

Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites

1995 • 187 citations

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

2001 • 175 citations

SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation

2003 • 166 citations

Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling

2002 • 166 citations

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

1997 • 163 citations

PIAS proteins promote SUMO-1 conjugation to STAT1

2003 • 150 citations

MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase

2001 • 150 citations

Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.

1994 • 129 citations

A novel factor required for the SUMO1/Smt3 conjugation of yeast septins

2001 • 128 citations

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression

1997 • 122 citations

PIASx Is a Transcriptional Co-repressor of Signal Transducer and Activator of Transcription 4

2003 • 121 citations

Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase

1995 • 121 citations

SOCS: suppressors of cytokine signalling

1998 • 108 citations

TheJanusprotein tyrosine kinases in hematopoietic cytokine signaling

1995 • 66 citations

Immunoreceptor Tyrosine-Based Inhibitory Motif of the IL-4 Receptor Associates with SH2-Containing Phosphatases and Regulates IL-4-Induced Proliferation

2001 • 59 citations