Evolution of the interleukins

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

The cytokine handbook

1994 • 1,121 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

1995 • 991 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Interleukin-18 Binding Protein

1999 • 759 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

The chicken B locus is a minimal essential major histocompatibility complex

1999 • 596 citations

IL-17: prototype member of an emerging cytokine family

2002 • 589 citations

Interleukin 20

2001 • 542 citations

Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9

2000 • 497 citations

Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression.

1995 • 479 citations

Purification and Characterization of the Human Interleukin-18 Receptor

1997 • 471 citations

A consensus linkage map of the chicken genome.

2000 • 468 citations

Differential cytokine expression in avian cells in response to invasion by Salmonella typhimurium, Salmonella enteritidis and Salmonella gallinarum The GenBank accession numbers for the sequences reported in this paper are AI982185 for chicken IL-6 cDNA and AJ250838 for the partial chicken IL-6 genomic sequence, respectively.

2000 • 393 citations

The role of IL-18 in innate immunity

2000 • 376 citations

Human/Mouse Homology Relationships

1996 • 373 citations

Selective Expression and Functions of Interleukin 18 Receptor on T Helper (Th) Type 1 but not Th2 Cells

1998 • 356 citations

The Genome of Fowlpox Virus

2000 • 326 citations

Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling

1998 • 326 citations

Potent Immunosuppressive Activities of Cytomegalovirus- Encoded Interleukin-10

2002 • 303 citations

Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

2000 • 285 citations

Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor

1999 • 267 citations

Prevalence of gastrointestinal helminths in different poultry production systems

1999 • 242 citations

MOLECULAR CLONING OF INTERLEUKIN 1β FROM RAINBOW TROUT ONCORHYNCHUS MYKISS REVEALS NO EVIDENCE OF AN ICE CUT SITE

1999 • 235 citations

IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

1996 • 225 citations

Human Monocytes Constitutively Express Membrane-Bound, Biologically Active, and Interferon-γ–Upregulated Interleukin-15

1999 • 221 citations

Induction of a Novel Cellular Homolog of Interleukin-10, AK155, by Transformation of T Lymphocytes with Herpesvirus Saimiri

2000 • 210 citations

Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein

1987 • 206 citations

IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes

2000 • 204 citations

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

1997 • 201 citations

Identification and analysis of an interleukin 8-like molecule in rainbow trout Oncorhynchus mykiss

2002 • 195 citations

Molecular cloning and expression analysis of carp ( ) interleukin-1β, high affinity immunoglobulin E Fc receptor γ subunit and serum amyloid A

2000 • 192 citations

Immunobiology of lnterleukin-12

1998 • 191 citations

Analysis of Chicken Mucosal Immune Response toEimeria tenellaandEimeria maximaInfection by Quantitative Reverse Transcription-PCR

2001 • 189 citations

Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins

2000 • 186 citations

Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms.

1997 • 182 citations

Marek's Disease Virus (MDV) Encodes an Interleukin-8 Homolog (vIL-8): Characterization of the vIL-8 Protein and a vIL-8 Deletion Mutant MDV

2001 • 165 citations

A chicken homolog of mammalian interleukin‐1β : cDNA cloning and purification of active recombinant protein

1998 • 160 citations

A cloned chicken lymphokine homologous to both mammalian IL-2 and IL-15.

1997 • 155 citations

Gene organisation determines evolution of function in the chicken MHC

1999 • 150 citations

Two-dimensional screening of the Wageningen chicken BAC library

2000 • 144 citations

Cloning and sequence analysis of the interleukin-8 gene from flounder (Paralichthys olivaceous)

2001 • 143 citations

Chicken interleukin‐6

2001 • 138 citations

Constitutive expression of a gene encoding a polypeptide homologous to biologically active human platelet protein in Rous sarcoma virus-transformed fibroblasts.

1987 • 129 citations

cDNA Cloning of Biologically Active Chicken Interleukin-18

2000 • 125 citations

Identification of an IL-8 homolog in lamprey (Lampetra fluviatilis ): early evolutionary divergence of chemokines

1999 • 123 citations

The rainbow troutOncorhynchus mykissinterleukin‐1β gene has a different organization to mammals and undergoes incomplete splicing

1999 • 119 citations

Molecular cloning of carp ( Cyprinus carpio ) CC chemokine, CXC chemokine receptors, allograft inflammatory factor-1, and natural killer cell enhancing factor by use of suppression subtractive hybridization

1999 • 118 citations

An Expressed Sequence Tag Database of T-Cell-Enriched Activated Chicken Splenocytes: Sequence Analysis of 5251 Clones

2000 • 104 citations

Molecular, cellular, and functional characterization of chicken cytokines homologous to mammalian IL-15 and IL-2

2001 • 102 citations

Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines.

1996 • 99 citations

Comparative Genomic Analysis of the Interferon/Interleukin-10 Receptor Gene Cluster

1999 • 95 citations

Cloning, sequencing, and analysis of expression of a second IL-1 β gene in rainbow trout (Oncorhynchus mykiss)

2000 • 95 citations

Interleukins 1 and 3 stimulate anion secretion in chicken intestine

1990 • 94 citations

A Large Database of Chicken Bursal ESTs as a Resource for the Analysis of Vertebrate Gene Function

2000 • 90 citations

The chicken 9E3/CEF4 CXC chemokine is the avian orthologue of IL8 and maps to chicken Chromosome 4 syntenic with genes flanking the mammalian chemokine cluster

1999 • 90 citations

Two burgeoning families of platelet factor 4-related proteins: mediators of the inflammatory response.

1990 • 87 citations

Isolation and Characterization of Chicken Interleukin-17 cDNA

2002 • 81 citations

Cloning and characterization of the Rainbow trout (Oncorhynchus mykiss) type II interleukin‐1 receptor cDNA

2000 • 80 citations

Crystal structure of epstein-barr virus protein BCRF1, a homolog of cellular interleukin-10 1 1Edited by R. Huber

1997 • 79 citations

Translational Efficiency Is Up-Regulated by Alternative Exon in Murine IL-15 mRNA

1998 • 72 citations

Promoter sequence, exon:intron structure, and synteny of genetic location show that a chicken cytokine with T-cell proliferative activity is IL2 and not IL15

1999 • 67 citations

Cloning of a Salmo salar interleukin-1 receptor-like cDNA

2002 • 63 citations

Manipulation of the Avian Genome

2019 • 63 citations

THE 9E3/CEF4 GENE PRODUCT IS A CHEMOTACTIC AND ANGIOGENIC FACTOR THAT CAN INITIATE THE WOUND-HEALING CASCADE IN VIVO

1998 • 61 citations

Evidence for the existence of an IL-2 like lymphocyte growth promoting factor in a bony fish, Cyprinuscarpio

1984 • 61 citations

Molecular cloning of the gene for interleukin-1? from Xenopus laevis and analysis of expression in vivo and in vitro

2000 • 61 citations

Transformation-associated cytokine 9E3/CEF4 is chemotactic for chicken peripheral blood mononuclear cells

1993 • 57 citations

Molecular and functional characterization of chickenIL-15

1999 • 55 citations

Genomic organization ot the type I and type II IL-1 receptors

1995 • 55 citations

The chicken IL-1 receptor: differential evolution of the cytoplasmic and extracellular domains

1992 • 52 citations

Molecular cloning and genomic structure of an interleukin-8 receptor-like gene from homozygous clones of rainbow trout (Oncorhynchus mykiss)

2002 • 51 citations

Phylogeny of interleukins: growth factors produced by leucocytes of the cyprinid fish, Cyprinus carpio L.

1984 • 50 citations

Mitogen-activated Xenopus laevis lymphocytes produce a T-cell growth factor.

1987 • 50 citations

Production and In Vitro Characterization of Recombinant Chicken Interleukin-2

1999 • 49 citations

The Interleukin-17 Gene of Herpesvirus Saimiri

1998 • 46 citations

Turkey and Chicken Interleukin-2 Cross-React inIn VitroProliferation Assays Despite Limited Amino Acid Sequence Identity

2000 • 43 citations

A Role for IL-15 in Driving the Onset of Spontaneous Autoimmune Thyroiditis?

2002 • 43 citations

The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling

1998 • 42 citations

PRESENCE OF IL-1- AND TNF-LIKE MOLECULES IN GALLERIA MELLONELLA(LEPIDOPTERA) HAEMOCYTES AND IN AN INSECT CELL LINE FROMESTIGMENE ACRAEA(LEPIDOPTERA)

1999 • 40 citations

Molecular analysis of chicken embryo SPARC (osteonectin)

1993 • 37 citations

Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family.

1995 • 36 citations

Cloning and expression of a putative common cytokine receptor gamma chain (γC) gene in rainbow trout (Oncorhynchus mykiss)

2001 • 36 citations

Production and characterisation of monoclonal antibodies specific for chicken interleukin-12

2010 • 36 citations

Primitive Cytokines and Cytokine Receptors in Invertebrates: the Sea Star Asterias rubens as a Model of Study

1996 • 31 citations

Characterisation of a monoclonal antibody to carp IL-1β and the development of a sensitive capture ELISA

2002 • 31 citations

Alterations in Macrophage-Produced Cytokines and Nitrite Associated with Poult Enteritis and Mortality Syndrome

2000 • 31 citations

Production and characterization of monoclonal antibodies detecting chicken interleukin-2 and the development of an antigen capture enzyme-linked immunosorbent assay

2001 • 31 citations

Identification of some components of basal lamina of avian ovarian follicle

2000 • 27 citations

The phylogeny of cytokines

2003 • 26 citations

Developing microsatellite markers from cDNA: a tool for adding expressed sequence tags to the genetic linkage map of the chicken

1998 • 26 citations

CHARACTERIZATION OF AN IL-6-LIKE MOLECULE FROM AN ECHINODERM (ASTERIAS FORBESI)

1996 • 24 citations

Interleukin-1? and its type 1 receptor are expressed in developing neural circuits in the frog,Xenopus laevis

1998 • 22 citations

Histochemical identification of tissue eosinophils in the inflammatory response of the fowl (Gallus domesticus)

1984 • 22 citations

Soluble type-I interleukin-1 receptor blocks chicken IL-1 activity

2001 • 22 citations

The 9E3 protein: immunolocalization in vivo and evidence for multiple forms in culture

1992 • 22 citations

Identification of functional receptors for ciliary neurotrophic factor on chick ciliary ganglion neurons

1996 • 21 citations

Further Characterization of an Interleukin‐2‐1Ike Cytokine Produced by Xenopus Laevis T Lymphocytes

1993 • 21 citations

Turkey and chicken interleukin-18 (IL18) share high sequence identity, but have different polyadenylation sites in their 3′ UTR

2002 • 21 citations

Presence of interleukins (IL-1, IL-3, IL-6) and the tumour necrosis factor (TNF alpha) in fish sera

1993 • 21 citations

Production and characterization of monoclonal antibodies reactive with the chicken interleukin-15 receptor alpha chain

2001 • 20 citations

Wound-factor-induced and cell cycle phase-dependent expression of 9E3/CEF4, the avian gro gene.

1991 • 18 citations

MUTATIONAL ANALYSIS OF CHICKEN INTERLEUKIN 2

2001 • 16 citations

Alternative splicing of mouse IL-15 is due to the use of an internal splice site in exon 5

1998 • 15 citations

Isolation and characterisation of a putative interleukin 13 receptor α2 sequence from rainbow trout (Oncorhynchus mykiss)

2001 • 15 citations

Mitogen-activated axolotl (Ambystoma mexicanum) splenocytes produce a cytokine that promotes growth of homologous lymphoblasts

1994 • 15 citations

The phylogeny of interleukin-2

1985 • 14 citations

Immune system activation associated with a naturally occurring infection in Xenopus laevis

1992 • 8 citations

Lectin (Cona) induced interleukin (IL-1a, IL-2, IL-6) production in vitro by leukocytes of rainbow trout (Oncorhynchus mykiss)

1994 • 7 citations

A Taq I polymorphism in the chicken interferon regulatory factor 1 ( IRF1 ) gene provides evidence that chicken linkage group E48C28W13 represents one of the microchromosomes

1999 • 4 citations