Induction of c-Myc Expression Suppresses Insulin Gene Transcription by Inhibiting NeuroD/BETA2-mediated Transcriptional Activation

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

1999 • 1,650 citations

A Matter of Life and Cell Death

1998 • 1,523 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

1997 • 1,011 citations

In vitro cultivation of human islets from expanded ductal tissue

2000 • 972 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

IPF1, a homeodomain-containing transactivator of the insulin gene.

1993 • 882 citations

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

1999 • 716 citations

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

1999 • 610 citations

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.

1995 • 601 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1996 • 548 citations

Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

1999 • 509 citations

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release.

1983 • 466 citations

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

1999 • 457 citations

Beta-cell adaptation and decompensation during the progression of diabetes.

2001 • 438 citations

IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

1994 • 427 citations

The role of c-myc in cell growth

1993 • 365 citations

Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.

1993 • 332 citations

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor.

1996 • 328 citations

Activation of the Hexosamine Pathway Leads to Deterioration of Pancreatic β-Cell Function through the Induction of Oxidative Stress

2001 • 317 citations

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

1995 • 283 citations

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer.

1987 • 242 citations

The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells

1996 • 218 citations

Action of Myc in vivo — proliferation and apoptosis

2000 • 193 citations

The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes.

1992 • 168 citations

Pdx1 Level Defines Pancreatic Gene Expression Pattern and Cell Lineage Differentiation

2001 • 166 citations

Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.

1996 • 155 citations

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.

1995 • 149 citations

The Insulin Gene Contains Multiple Transcriptional Elements That Respond to Glucose

1994 • 145 citations

Reduced Insulin, GLUT2, and IDX-1 in β-Cells After Partial Pancreatectomy

1997 • 131 citations

Transcription Factor BETA2 Acts Cooperatively with E2A and PDX1 to Activate the Insulin Gene Promoter

2000 • 128 citations

Pancreatic β-Cell-specific Repression of Insulin Gene Transcription by CCAAT/Enhancer-binding Protein β

1997 • 123 citations

Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells.

1989 • 121 citations

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.

1998 • 121 citations

Glucose-Induced Transcription of the Insulin Gene Is Mediated by Factors Required for β-Cell-Type-Specific Expression

1994 • 118 citations

High Glucose Stimulates Early Response Gene c-Myc Expression in Rat Pancreatic β Cells

2001 • 109 citations

c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements.

1992 • 109 citations

Functional Characterization of the Transactivation Properties of the PDX-1 Homeodomain Protein

1997 • 96 citations

The NeuroD1/BETA2 Sequences Essential for Insulin Gene Transcription Colocalize with Those Necessary for Neurogenesis and p300/CREB Binding Protein Binding

1999 • 95 citations

Identification of a Pancreatic β-Cell Insulin Gene Transcription Factor That Binds to and Appears To Activate Cell-Type-Specific Expression: Its Possible Relationship to Other Cellular Factors That Bind to a Common Insulin Gene Sequence

1990 • 94 citations

Hydrogen peroxide-induced expression of the proto-oncogenes, c-jun, c-fos and c-myc in rabbit lens epithelial cells.

1997 • 72 citations

Expression of Heparin-binding Epidermal Growth Factor-like Growth Factor during Pancreas Development

1997 • 71 citations

Involvement of Protein Kinase C β2 in c-mycInduction by High Glucose in Pancreatic β-Cells

2002 • 58 citations

A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets

1998 • 57 citations

Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription.

1994 • 37 citations

c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control.

1994 • 37 citations

c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products

1995 • 34 citations