Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

1997 • 1,144 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and β-pancreatic islet cells

1988 • 786 citations

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

2000 • 653 citations

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.

1998 • 554 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

1997 • 549 citations

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

1993 • 536 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas

2000 • 513 citations

Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons

1988 • 455 citations

Compensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion

1989 • 447 citations

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.

2000 • 443 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Beta-cell adaptation and decompensation during the progression of diabetes.

2001 • 438 citations

N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

2001 • 428 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

1998 • 381 citations

Function of the c-Myc Oncogenic Transcription Factor

1999 • 379 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.

1999 • 339 citations

Islet growth and development in the adult

2000 • 338 citations

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

1997 • 299 citations

Control of cell growth by c-Myc in the absence of cell division

1999 • 290 citations

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

1995 • 283 citations

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

1996 • 282 citations

A unique glucose-dependent apoptotic pathway induced by c-Myc

1998 • 280 citations

Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney

1997 • 256 citations

Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas.

1995 • 209 citations

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors.

1996 • 206 citations

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

2002 • 199 citations

Action of Myc in vivo — proliferation and apoptosis

2000 • 193 citations

Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

2000 • 188 citations

Pancreatic tumor pathogenesis reflects the causative genetic lesion.

1991 • 158 citations

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

1999 • 153 citations

Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia

1996 • 143 citations

Insulitis in transgenic mice expressing tumor necrosis factor beta (lymphotoxin) in the pancreas.

1992 • 128 citations

Rat Endocrine Pancreatic Development in Relation to Two Homeobox Gene Products (Pdx-1 and Nkx 6.1)

1998 • 120 citations

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappa B activation

1997 • 113 citations

High Glucose Stimulates Early Response Gene c-Myc Expression in Rat Pancreatic β Cells

2001 • 109 citations

Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion

1989 • 104 citations

The NeuroD1/BETA2 Sequences Essential for Insulin Gene Transcription Colocalize with Those Necessary for Neurogenesis and p300/CREB Binding Protein Binding

1999 • 95 citations

Functional analysis of a conditionally transformed pancreatic beta-cell line.

1998 • 90 citations

Transcriptional Regulation of Genes Encoding Insulin, Glucagon, and Angiotensinogen by Sodium Butyrate in a Rat Islet Cell Line

1987 • 83 citations

Induction of c-Myc Expression Suppresses Insulin Gene Transcription by Inhibiting NeuroD/BETA2-mediated Transcriptional Activation

2002 • 76 citations

Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis

1999 • 74 citations

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat

1995 • 71 citations

Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line.

1987 • 54 citations

Molecular genetics of malignant insulinoma.

1996 • 51 citations

Transient coappearance of glucagon and insulin in the progenitor cells of the rat pancreatic islets

1988 • 49 citations

Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis

1997 • 38 citations

Stimulation of pancreatic islet beta-cell replication by oncogenes.

1988 • 37 citations

Glucose Stimulation of Protooncogene Expression and Deoxyribonucleic Acid Synthesis in Rat Islet Cell Line

1988 • 22 citations

An in vitro model of the early genetic events in multistage carcinogenesis of malignant insulinoma

1999 • 5 citations

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