NF-κB: a key role in inflammatory diseases

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

2001 • 1,548 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

NF-κB in neuronal plasticity and neurodegenerative disorders

2001 • 845 citations

Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice

1996 • 839 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

NF-κB: pivotal mediator or innocent bystander in atherogenesis?

2001 • 729 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

New Insights into the Role of Nuclear Factor-κB, a Ubiquitous Transcription Factor in the Initiation of Diseases

1999 • 717 citations

Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-jun N-terminal kinase, and nuclear factor κB: Differential regulation of collagenase 1 and collagenase 3

2000 • 625 citations

Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding

1999 • 517 citations

NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

1998 • 462 citations

Direct Phosphorylation of IκB by IKKα and IKKβ: Discrimination Between Free and NF-κB-Bound Substrate

1998 • 450 citations

Activation and Localization of Transcription Factor, Nuclear Factor- κ B, in Asthma

1998 • 422 citations

AP-1 and NF-kB Regulation in Rheumatoid Arthritis and Murine Collagen-Induced Arthritis

1998 • 367 citations

NAK is an IκB kinase-activating kinase

2000 • 365 citations

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases

1999 • 362 citations

Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation

1998 • 304 citations

Inhibitor of nuclear factor ?B kinase ? is a key regulator of synovial inflammation

2001 • 234 citations

Cytokine Gene Transcription By NF‐κB Family Members in Patients with Inflammatory Bowel Disease

1998 • 223 citations

Nuclear factor ?B/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1?-stimulated synovial fibroblasts

1998 • 222 citations

Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor ?B decoy oligodeoxynucleotides as a gene therapy

1999 • 221 citations

Signal transduction and transcription factors in rheumatic disease

1999 • 197 citations

Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation.

1995 • 190 citations

Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo.

1999 • 167 citations

Dual regulation of IL-1 beta-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-kappa B and AP-1

1996 • 164 citations

High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation

2000 • 159 citations

Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.

1999 • 159 citations

Preferential Role for NF-κB/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo

1999 • 146 citations

Thrombin-Induced p65 Homodimer Binding to Downstream NF-κB Site of the Promoter Mediates Endothelial ICAM-1 Expression and Neutrophil Adhesion

1999 • 132 citations

NF-kappa B/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation.

1999 • 127 citations

Activation of transcription factor NF-κB in experimental glomerulonephritis in rats

1996 • 124 citations

A New Member of the IκB Protein Family, IκBε, Inhibits RelA (p65)-Mediated NF-κB Transcription

1997 • 119 citations

NF-κB/Rel Transcription Factors: c-Rel Promotes Airway Hyperresponsiveness and Allergic Pulmonary Inflammation

1999 • 116 citations

Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1.

1998 • 104 citations

P53 overexpression in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis

1999 • 101 citations

NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.

1999 • 99 citations

The Effect of a T Cell-Specific NF-κB Inhibitor on In Vitro Cytokine Production and Collagen-Induced Arthritis

2000 • 99 citations

NF-κB Regulation by IκB Kinase in Primary Fibroblast-Like Synoviocytes

1999 • 95 citations

Essential role of T cell NF-kappa B activation in collagen-induced arthritis.

1999 • 87 citations

Expression and Activation of NF-κB in the Antrum of the Human Stomach

2000 • 85 citations

The Effect of Dexamethasone on the Expression of Activated NF-κB in Adjuvant Arthritis

1997 • 75 citations

Essential Role of T Cell NF-κB Activation in Collagen-Induced Arthritis

1999 • 69 citations

A Functional Role of IκB-ε in Endothelial Cell Activation

2000 • 67 citations

Increased nuclear factor-kappaB activation in colitis of interleukin-2-deficient mice

1999 • 24 citations