Lymphotoxin and LIGHT signaling pathways and target genes

Innate Immune Recognition

2002 • 8,157 citations

Toll-Like Receptors

2003 • 6,127 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

2003 • 3,164 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes

2003 • 2,545 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

A chemokine-driven positive feedback loop organizes lymphoid follicles

2000 • 1,220 citations

Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family

1996 • 1,068 citations

Chemokines and Cell Migration in Secondary Lymphoid Organs

1999 • 1,046 citations

Mice Lacking Expression of Secondary Lymphoid Organ Chemokine Have Defects in Lymphocyte Homing and Dendritic Cell Localization

1999 • 1,030 citations

Viruses and Interferons

2001 • 985 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

2003 • 917 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

The molecular architecture of the TNF superfamily

2002 • 863 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

1998 • 760 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

Requirement for RORγ in Thymocyte Survival and Lymphoid Organ Development

2000 • 714 citations

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

1999 • 636 citations

Lymphotoxin α/β and Tumor Necrosis Factor Are Required for Stromal Cell Expression of Homing Chemokines in B and T Cell Areas of the Spleen

1999 • 552 citations

Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis

2002 • 530 citations

Genomewide Search in Canadian Families with Inflammatory Bowel Disease Reveals Two Novel Susceptibility Loci

2000 • 508 citations

NF-κB Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions

2002 • 489 citations

The signaling adaptors and pathways activated by TNF superfamily

2003 • 481 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

2002 • 468 citations

CD40 regulates the processing of NF-kappaB2 p100 to p52

2002 • 435 citations

To kill or be killed: viral evasion of apoptosis

2002 • 429 citations

Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h

2001 • 417 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.

1996 • 405 citations

LIGHT, a TNF-Like Molecule, Costimulates T Cell Proliferation and Is Required for Dendritic Cell-Mediated Allogeneic T Cell Response

2000 • 394 citations

A Newly Identified Member of Tumor Necrosis Factor Receptor Superfamily (TR6) Suppresses LIGHT-mediated Apoptosis

1999 • 370 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Structure and Function of the Interferon- Enhanceosome

1998 • 354 citations

Priming of naive T cells inside tumors leads to eradication of established tumors

2004 • 344 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

2000 • 309 citations

Retinoid-related orphan receptor γ (RORγ) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis

2000 • 308 citations

Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen.

1990 • 305 citations

A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation

1997 • 302 citations

B Lymphocytes Induce the Formation of Follicular Dendritic Cell Clusters in a Lymphotoxin α–dependent Fashion

1998 • 296 citations

Lymphotoxin/LIGHT, lymphoid microenvironments and autoimmune disease

2003 • 291 citations

LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer.

1998 • 277 citations

Altered Cellular mRNA Levels in Human Cytomegalovirus-Infected Fibroblasts: Viral Block to the Accumulation of Antiviral mRNAs

2001 • 273 citations

Dendritic Cells

1999 • 269 citations

Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis

2002 • 255 citations

Splenic T Zone Development Is B Cell Dependent

2001 • 245 citations

Initial and innate responses to viral infections — pattern setting in immunity or disease

1999 • 241 citations

Herpesvirus Entry Mediator Ligand (HVEM-L), a Novel Ligand for HVEM/TR2, Stimulates Proliferation of T Cells and Inhibits HT29 Cell Growth

1998 • 241 citations

Constitutive Expression of LIGHT on T Cells Leads to Lymphocyte Activation, Inflammation, and Tissue Destruction

2001 • 240 citations

Different Cytokines Induce Surface Lymphotoxin-αβ on IL-7 Receptor-α Cells that Differentially Engender Lymph Nodes and Peyer's Patches

2002 • 240 citations

Targeted Disruption of TRAF3 Leads to Postnatal Lethality and Defective T-Dependent Immune Responses

1996 • 239 citations

The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles

1998 • 232 citations

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT

2001 • 225 citations

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT

2001 • 213 citations

Distinct Role of Surface Lymphotoxin Expressed by B Cells in the Organization of Secondary Lymphoid Tissues

2002 • 201 citations

Biology of the TRANCE axis

2003 • 197 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

Lymphoid Tissue Homing Chemokines Are Expressed in Chronic Inflammation

2000 • 193 citations

Lymphotoxin-α (LTα) Supports Development of Splenic Follicular Structure That Is Required for IgG Responses

1997 • 193 citations

Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

1997 • 192 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells.

1992 • 183 citations

Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes.

1997 • 175 citations

Lymphotoxin ॆ Receptor Induces Sequential Activation of Distinct NF-κB Factors via Separate Signaling Pathways

2003 • 171 citations

The TNF Superfamily Members LIGHT and CD154 (CD40 Ligand) Costimulate Induction of Dendritic Cell Maturation and Elicit Specific CTL Activity

2001 • 171 citations

Chemokines and dendritic cell traffic.

2000 • 171 citations

Secreted Lymphotoxin-α Is Essential for the Control of an Intracellular Bacterial Infection

2001 • 168 citations

The Requirement of Membrane Lymphotoxin for the Presence of Dendritic Cells in Lymphoid Tissues

1999 • 160 citations

Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3-Containing Interferon-Stimulated Response Element-Binding Complex

1998 • 158 citations

Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis

1998 • 154 citations

Signaling via LTβR on the lamina propria stromal cells of the gut is required for IgA production

2002 • 152 citations

The Lymphotoxin β Receptor Is Critically Involved in Controlling Infections with the Intracellular Pathogens Mycobacterium tuberculosis and Listeria monocytogenes

2003 • 147 citations

RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation

2003 • 147 citations

Expression of α4β7 Integrin Defines a Distinct Pathway of Lymphoid Progenitors Committed to T Cells, Fetal Intestinal Lymphotoxin Producer, NK, and Dendritic Cells

2001 • 138 citations

Requirement for membrane lymphotoxin in natural killer cell development

1999 • 137 citations

Lymphoid organ development and cell migration

2003 • 135 citations

B Cells Control the Migration of a Subset of Dendritic Cells into B Cell Follicles Via CXC Chemokine Ligand 13 in a Lymphotoxin-Dependent Fashion

2002 • 124 citations

A co-evolution perspective of the TNFSF and TNFRSF families in the immune system

2003 • 121 citations

Cutting Edge: Organogenesis of Nasal-Associated Lymphoid Tissue (NALT) Occurs Independently of Lymphotoxin-α (LTα) and Retinoic Acid Receptor-Related Orphan Receptor-γ, but the Organization of NALT Is LTα Dependent

2002 • 121 citations

Reversal of Spontaneous Autoimmune Insulitis in Nonobese Diabetic Mice by Soluble Lymphotoxin Receptor

2001 • 120 citations

The TNF Superfamily

2003 • 119 citations

A Role for the Lymphotoxin/LIGHT Axis in the Pathogenesis of Murine Collagen-Induced Arthritis

2003 • 119 citations

Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy

2004 • 118 citations

Organogenesis of peripheral lymphoid organs

2003 • 112 citations

Death and survival: viral regulation of TNF signaling pathways

2003 • 108 citations

Lymphotoxin-α-Deficient Mice Make Delayed, But Effective, T and B Cell Responses to Influenza

2002 • 103 citations

Lymphotoxins and Cytomegalovirus Cooperatively Induce Interferon-β, Establishing Host-Virus Détente

2001 • 96 citations

Cutting Edge: Selective Impairment of CD8+ T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT

2002 • 94 citations

Visualization of Lymphotoxin-β and Lymphotoxin-β Receptor Expression in Mouse Embryos

2002 • 84 citations

Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease

2002 • 82 citations

Differential induction of adhesion molecule and chemokine expression by LTalpha3 and LTalphabeta in inflammation elucidates potential mechanisms of mesenteric and peripheral lymph node development.

1999 • 79 citations

Lymphotoxin α−/− Mice Develop Functionally Impaired CD8+ T Cell Responses and Fail to Contain Virus Infection of the Central Nervous System

2001 • 78 citations

The Critical Role of LIGHT, a TNF Family Member, in T Cell Development

2001 • 77 citations

TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes.

1999 • 77 citations

Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo

2003 • 76 citations

Genomic Characterization of LIGHT Reveals Linkage to an Immune Response Locus on Chromosome 19p13.3 and Distinct Isoforms Generated by Alternate Splicing or Proteolysis

2001 • 75 citations

The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function

2002 • 71 citations

Differential Induction of Adhesion Molecule and Chemokine Expression by LTα3 and LTαβ in Inflammation Elucidates Potential Mechanisms of Mesenteric and Peripheral Lymph Node Development

1999 • 68 citations

Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease

2002 • 68 citations

Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment.

1999 • 67 citations

Signal Via Lymphotoxin-βR on Bone Marrow Stromal Cells Is Required for an Early Checkpoint of NK Cell Development

2001 • 66 citations

CD40 ligation induces lymphotoxin α gene expression in human B cells

1994 • 66 citations

Shaping Up Adaptive Immunity: The Impact of CCR7 and CXCR5 on Lymphocyte Trafficking

2003 • 66 citations

TNF and Lymphotoxin β Cooperate in the Maintenance of Secondary Lymphoid Tissue Microarchitecture But Not in the Development of Lymph Nodes

1999 • 65 citations

A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT

2003 • 64 citations

Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

1999 • 63 citations

Blocking lymphotoxin-βreceptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis

2004 • 58 citations

A Critical Role for Lymphotoxin-β Receptor in the Development of Diabetes in Nonobese Diabetic Mice

2001 • 56 citations

Lymphotoxin alphabeta is expressed on recently activated naive and Th1-like CD4 cells but is down-regulated by IL-4 during Th2 differentiation.

1999 • 53 citations

Lymphotoxin-α-Deficient Mice Can Clear a Productive Infection with Murine Gammaherpesvirus 68 but Fail To Develop Splenomegaly or Lymphocytosis

2000 • 53 citations

Structurally Distinct Recognition Motifs in Lymphotoxin-β Receptor and CD40 for Tumor Necrosis Factor Receptor-associated Factor (TRAF)-mediated Signaling

2003 • 51 citations

SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling

2004 • 51 citations

Mice with a Targeted Mutation in Lymphotoxin-α Exhibit Enhanced Tumor Growth and Metastasis: Impaired NK Cell Development and Recruitment

1999 • 51 citations

Lymphotoxin αβ Is Expressed on Recently Activated Naive and Th1-Like CD4 Cells but Is Down-Regulated by IL-4 During Th2 Differentiation

1999 • 51 citations

Role of Lymphotoxin α in T-Cell Responses during an Acute Viral Infection

2002 • 49 citations

Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands.

1995 • 47 citations

Lymphotoxin Is Required for Maintaining Physiological Levels of Serum IgE That Minimizes Th1-mediated Airway Inflammation

2003 • 45 citations

Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice.

1999 • 44 citations

A role for lymphotoxin β receptor in host defense againstMycobacterium bovis BCG infection

1999 • 43 citations

LIGHT‐deficiency impairs CD8+ T cell expansion, but not effector function

2003 • 40 citations

Multiple Deficiencies Underlie NK Cell Inactivity in Lymphotoxin-α Gene-Targeted Mice

1999 • 37 citations

Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs

2002 • 36 citations

LIGHT (a Cellular Ligand for Herpes Virus Entry Mediator and Lymphotoxin Receptor)-Mediated Thymocyte Deletion Is Dependent on the Interaction Between TCR and MHC/Self-Peptide

2003 • 30 citations

Membrane lymphotoxin is required for resistance to Theiler's virus infection

2003 • 24 citations

Cyclosporin A blocks the expression of lymphotoxin α, but not lymphotoxin β, in human peripheral blood mononuclear cells

2002 • 20 citations

Studies of membrane-associated and soluble (secreted) lymphotoxin in human lymphokine-activated T-killer cells in vitro.

1992 • 19 citations

Blockade of Lymphotoxin Signaling Inhibits the Clinical Expression of Murine Graft-versus-Host Skin Disease

2004 • 14 citations

Transforming growth factor-beta 1 down-regulates expression of membrane-associated lymphotoxin and secretion of soluble lymphotoxin by human lymphokine-activated killer T cells in vitro.

1992 • 7 citations