Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment.

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

Role of NK cells in tumour growth and metastasis in beige mice

1980 • 524 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

The Ets-1 Transcription Factor Is Required for the Development of Natural Killer Cells in Mice

1998 • 351 citations

B Lymphocytes Induce the Formation of Follicular Dendritic Cell Clusters in a Lymphotoxin α–dependent Fashion

1998 • 296 citations

Lymph Node Genesis Is Induced by Signaling through the Lymphotoxin β Receptor

1998 • 294 citations

Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver.

1985 • 275 citations

IFN-gamma-inducing factor/IL-18 administration mediates IFN-gamma- and IL-12-independent antitumor effects.

1998 • 229 citations

Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism.

1996 • 227 citations

Tumor Necrosis Factor α and Lymphotoxin α Are Not Required for Induction of Acute Experimental Autoimmune Encephalomyelitis

1997 • 197 citations

Lymphotoxin-α (LTα) Supports Development of Splenic Follicular Structure That Is Required for IgG Responses

1997 • 193 citations

Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

1997 • 192 citations

A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis

1997 • 187 citations

Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells.

1992 • 183 citations

Perforin dependence of natural killer cell‐mediated tumor control in vivo

1995 • 161 citations

Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines.

1996 • 153 citations

T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas.

1998 • 152 citations

Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis.

1994 • 147 citations

Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors.

1995 • 146 citations

An Essential Role for Tumor Necrosis Factor in Natural Killer Cell–mediated Tumor Rejection in the Peritoneum

1998 • 140 citations

NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction.

1996 • 120 citations

Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node

1997 • 105 citations

TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus.

1998 • 101 citations

Angiostatin-mediated Suppression of Cancer Metastases by Primary Neoplasms Engineered to Produce Granulocyte/Macrophage Colony–stimulating Factor

1998 • 84 citations

Molecular Mechanisms of Immune-Mediated Lysis of Murine Renal Cancer: Differential Contributions of Perforin-Dependent Versus Fas-Mediated Pathways in Lysis by NK and T Cells

1998 • 83 citations

A Role for Tumor Necrosis Factor Receptor Type 1 in Gut-associated Lymphoid Tissue Development: Genetic Evidence of Synergism with Lymphotoxin β

1998 • 74 citations

Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene.

1988 • 62 citations

Regulation of local host-mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis.

1997 • 59 citations

Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow.

1989 • 55 citations

TNF-alpha is a principal cytokine involved in the recruitment of NK cells to liver parenchyma.

1994 • 47 citations

Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes.

1997 • 39 citations

Involvement of B lymphocytes in the growth inhibition of human pulmonary melanoma metastases in athymic nu/nu mice by an antibody-lymphotoxin fusion protein.

1996 • 37 citations

TNF promotes metastasis by impairing natural killer cell activity

1996 • 35 citations

The Fas-Based Mechanism of Lymphocytotoxicity

1997 • 34 citations

Transgenic expression of lymphotoxin restores lymph nodes to lymphotoxin-alpha-deficient mice.

1997 • 33 citations

Generation of a Systemic Antitumor Response with Regional Intratumoral Injections of InterferonγRetroviral Vector

1998 • 23 citations

Increase in liver-associated natural killer activity by polyribonucleotides.

1987 • 14 citations

B16 Melanoma Cells ExposedIn Vitroto Long-Term IFN-α Treatment (B16α Cells) as Activators of Tumor Immunity in Mice

1997 • 10 citations

Murine Lymph Node Natural Killer Cells: Regulatory Mechanisms of Activation or Suppression<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1982 • 8 citations

Membrane-Associated Lymphotoxin-Expressing Lymphokine-Activated Killer Cells Up-Regulate Intercellular Adhesion Molecule-1 Expression on Target Tumor Cells in Vitro

1995 • 3 citations