Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose.

1987 • 819 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity

1986 • 671 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.

1991 • 553 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Structure of tumour necrosis factor

1989 • 512 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

1985 • 509 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Molecular Cloning and Expression of Rat Interleukin-1α cDNA

1989 • 332 citations

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

1986 • 312 citations

A New Cluster of Genes Within the Human Major Histocompatibility Complex

1989 • 247 citations

Tumour necrosis factor and lymphotoxin genes map close to H–2D in the mouse major histocompatibility complex

1987 • 230 citations

The Inhibin/Activin Family of Hormones and Growth Factors

1990 • 220 citations

Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody.

1988 • 187 citations

The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

1992 • 187 citations

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

1991 • 186 citations

Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells.

1992 • 183 citations

A new superfamily of cell surface proteins related to the nerve growth factor receptor

1991 • 172 citations

Programmed cell death and AIDS: from hypothesis to experiment

1992 • 167 citations

A Tumour Necrosis Factor Beta Gene Polymorphism in Relation to Monokine Secretion and Insulin‐Dependent Diabetes Mellitus

1991 • 156 citations

Stimulated kidney tubular epithelial cells express membrane associated and secreted TNFα

1991 • 151 citations

Tumour necrosis factor is a compact trimer

1987 • 136 citations

Tandem Arrangement of Genes Coding for Tumor Necrosis Factor (TNF- ) and Lymphotoxin (TNF- ) in the Human Genome

1986 • 133 citations

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells.

1990 • 133 citations

Tumor necrosis factor expression in human epithelial tumor cell lines.

1988 • 102 citations

Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma.

1992 • 97 citations

Some disease-associated ancestral haplotypes carry a polymorphism of TNF

1989 • 79 citations

Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines.

1989 • 78 citations

Genetic variability at the human tumor necrosis factor loci.

1990 • 72 citations

Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position.

1987 • 71 citations

NcoI Restriction Fragment Length Polymorphism (RFLP) of the Tumour Necrosis Factor (TNFα) Region in Primary Biliary Cirrhosis and in Healthy Danes

1989 • 71 citations

Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma.

1991 • 68 citations

Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development.

1992 • 64 citations

A polymorphic microsatellite in the tumor necrosis factor alpha promoter identifies an allele unique to the NZW mouse strain.

1990 • 62 citations

A gene in the H-2S : H-2D interval of the major histocompatibility complex which is transcribed in B cells and macrophages

1987 • 54 citations

Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma.

1990 • 44 citations

Expression of Membrane‐associated Lymphotoxin/Tumor Necrosis Factor‐β on Human Lymphokine‐activated Killer Cells

1991 • 22 citations

Studies of membrane-associated and soluble (secreted) lymphotoxin in human lymphokine-activated T-killer cells in vitro.

1992 • 19 citations

Cachectin/Tumor Necrosis Factor and Lymphotoxin

1990 • 18 citations

TNF‐alpha GENE POLYMORPHISMS: ASSOCIATION WITH TYPE I (INSULIN‐DEPENDENT) DIABETES MELLITUS

1989 • 16 citations

Correlation between killing activity towards the murine L929 cell line and expression of membrane‐associated lymphotoxin‐related molecule of human lymphokine‐activated killer cells

1992 • 16 citations

The Role of Lymphotoxin in Inflammation

1988 • 15 citations

Conserved residues of tumour necrosis factor and lymphotoxin constitute the framework of the trimeric structure

1989 • 12 citations

Membrane‐associated Lymphotoxin Expression and Functional Analysis of Lymphokine‐activated Killer Cells Derived from Tumor‐infiltrating Lymphocytes

1993 • 9 citations

Taking the thymus to pieces

1992 • 5 citations