Effect of iron chelators on the cytotoxic and genotoxic action of hyperoxia in Chinese hamster ovary cells

New Giemsa method for the differential staining of sister chromatids

1974 • 3,198 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

The aging process.

1981 • 1,871 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Oxidative Stress: Introductory Remarks

1985 • 979 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction

1984 • 350 citations

Endogenous DNA damage as related to cancer and aging

1989 • 323 citations

Ferric iron and superoxide ions are required for the killing of cultured hepatocytes by hydrogen peroxide. Evidence for the participation of hydroxyl radicals formed by an iron-catalyzed Haber-Weiss reaction.

1985 • 300 citations

Oxygen toxicity and reactive oxygen metabolites in mammals

1989 • 228 citations

The Toxicology of Molecular Oxygen

1984 • 210 citations

Genetic toxicology of oxygen

1989 • 198 citations

Endogenous carcinogenesis: molecular oncology into the twenty-first century--presidential address.

1989 • 189 citations

Is hydroxyl radical generated by the Fenton reaction in vivo?

1985 • 173 citations

Pyruvate and related α-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity

1985 • 154 citations

Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species

1985 • 139 citations

Effect of oxygen tension on HeLa cell growth.

1960 • 111 citations

The enzymatic oxidation of Desferal to a nitroxide free radical

1987 • 111 citations

Statistical evaluation of mutagenicity test data

1991 • 106 citations

Oxygen-based Free Radical Generation by Ferrous Ions and Deferoxamine

1989 • 101 citations

Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia.

1990 • 100 citations

Spectrum and Iron Content of Protein B2 from Ribonucleoside Diphosphate Reductase

1969 • 100 citations

Is superoxide important in oxygen poisoning?

1982 • 98 citations

Superoxide and superoxide-dependent formation of hydroxyl radicals are important in oxygen toxicity

1982 • 82 citations

The free radical theory of aging: A critical review

1985 • 82 citations

Iron-mediated induction of sister-chromatid exchanges by hydrogen peroxide and superoxide anion

1987 • 75 citations

Some characteristics of hyperoxia-adapted HeLa cells. A tissue culture model for cellular oxygen tolerance.

1985 • 70 citations

Does Heat Shock Enhance Oxidative Stress? Studies with Ferrous and Ferric Iron

1990 • 63 citations

Influence of oxygen tension, pro-oxidants and antioxidants on the formation of lipid peroxidation products (lipofuscin) in individual cultivated human glial cells

1984 • 58 citations

Basic mutagenicity tests—UKEMS recommended procedures

1991 • 52 citations

Hyperoxia-induced clonogenic killing of HeLa cells associated with respiratory failure and selective inactivation of Krebs cycle enzymes

1990 • 46 citations

Effects of lethal exposure to hyperoxia and to hydrogen peroxide on NAD(H) and ATP pools in Chinese hamster ovary cells

1989 • 36 citations

Chromosomal instability in an oxygen-tolerant variant of Chinese hamster ovary cells

1989 • 26 citations

Free Radical Mediated Cytotoxicity of Desferrioxamine

1989 • 21 citations

Cell cycle specific effects of deferoxamine on human and murine hematopoietic progenitor cells.

1988 • 20 citations

Partial correction of chromosome instability in Fanconi anemia by desferrioxamine

1989 • 18 citations

Desferrioxamine-induced alterations in hepatic iron distribution, DNA damage and lipid peroxidation in control and 2, 3, 7,8-tetrachlorodibenzo-p-dioxin-treated rats

1990 • 14 citations

Superoxide toxicity

1982 • 3 citations