Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Reactions of oxyl radicals with DNA

1995 • 1,041 citations

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1992 • 875 citations

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

1992 • 688 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

Substrate specificity of the Escherichia coli Fpg protein formamidopyrimidine-DNA glycosylase: excision of purine lesions in DNA produced by ionizing radiation or photosensitization

1992 • 597 citations

Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair

1998 • 502 citations

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

1993 • 437 citations

Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

1996 • 386 citations

The enzymology of apurinic/apyrimidinic endonucleases

1990 • 378 citations

Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.

1996 • 352 citations

Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

1997 • 350 citations

Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.

1990 • 347 citations

Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites

1997 • 344 citations

New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

1994 • 337 citations

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

1997 • 328 citations

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

1979 • 257 citations

Methylation of the O⁶Position of Guanine in DNA is the Most Likely Initiating Event in Carcinogenesis by Methylating Agents

1984 • 236 citations

The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution

1997 • 165 citations

Stereochemical studies of the .beta.-elimination reactions at aldehydic abasic sites in DNA: endonuclease III from Escherichia coli, sodium hydroxide, and Lys-Trp-Lys

1991 • 160 citations

Mechanism of DNA strand nicking at apurinic/apyrimidinic sites by Escherichia coli [formamidopyrimidine]DNA glycosylase

1989 • 157 citations

Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli.

1996 • 153 citations

Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role.

1993 • 143 citations

DNA Replication Fidelity with 8-Oxodeoxyguanosine Triphosphate

1994 • 129 citations

The Catalytic Mechanism of Fpg Protein

1995 • 124 citations

The Ogg1 protein of Saccharomyces cerevisiae: a 7,8-dihydro-8- oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity

1997 • 123 citations

Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals

1998 • 111 citations

Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical

1998 • 97 citations

Cleavage and binding of a DNA fragment containing a single 8-oxoguanine by wild type and mutant FPG proteins

1993 • 91 citations

Repair of oxidatively damaged guanine in Saccharomyces cerevisiae by an alternative pathway

1998 • 77 citations

Saccharomyces cerevisiae Possesses Two Functional Homologues of Escherichia coli Endonuclease III

1998 • 75 citations

Purification and characterization of Escherichia coli formamidopyrimidine-DNA glycosylase that excises damaged 7-methylguanine from deoxyribonucleic acid

1981 • 73 citations

Heterogeneous repair of N -methylpurines at the nucleotide level in normal human cells 1 1Edited by M. Yahiv

1998 • 71 citations

Mechanism of Action of Base Release by Escherichia coli Fpg Protein: Role of Lysine 155 in Catalysis

1997 • 71 citations

Biological properties of imidazole ring-opened N7-methylguanine in M13mp18 phage DNA

1992 • 67 citations

Human MMH (OGG1) Type 1a Protein Is a Major Enzyme for Repair of 8-Hydroxyguanine Lesions in Human Cells

1999 • 50 citations

In search of a mutational hotspot

1998 • 49 citations

Correlation between Sequence-dependent Glycosylase Repair and the Thermal Stability of Oligonucleotide Duplexes Containing 1,N 6-Ethenoadenine

1998 • 35 citations

Template-directed interference footprinting of protein-guanine contacts in DNA

1991 • 31 citations

DNA repair: How yeast repairs radical damage

1996 • 16 citations

Synthesis and characterization of oligonucleotides containing the alpha-anomer of deoxyadenosine to study its influence on DNA replication.

1993 • 13 citations

Sequence specificity of DNA repair by Escherichia coli Fpg protein

1992 • 11 citations