Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications.

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

Going APE over ref-1

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Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

1997 • 477 citations

The enzymology of apurinic/apyrimidinic endonucleases

1990 • 378 citations

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

1979 • 257 citations

Human Thymine DNA Glycosylase Binds to Apurinic Sites in DNA but Is Displaced by Human Apurinic Endonuclease 1

1999 • 251 citations

Substrate Specificity and Reaction Mechanism of Murine 8-Oxoguanine-DNA Glycosylase

2000 • 192 citations

Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli.

1992 • 147 citations

Enhanced Mitochondrial DNA Repair and Cellular Survival after Oxidative Stress by Targeting the Human 8-Oxoguanine Glycosylase Repair Enzyme to Mitochondria

2000 • 142 citations

Proliferation is necessary for both repair and mutation in transgenic mouse cells

2000 • 117 citations

Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine

2000 • 113 citations

Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals

1998 • 111 citations

Characterization and Mechanism of Action of DrosophilaRibosomal Protein S3 DNA Glycosylase Activity for the Removal of Oxidatively Damaged DNA Bases

1997 • 82 citations

Review of mammalian DNA repair and translational implications.

2000 • 75 citations

Mechanism of action of the nitrosoureas—IV

1980 • 51 citations

DNA repair and gene therapy: Implications for translational uses

2000 • 38 citations

Creation of a Fully Functional Human Chimeric DNA Repair Protein

1998 • 37 citations

Fibronectin Fragment-Facilitated Retroviral Transfer of the Glutathione-S-Transferase π Gene into CD34⁺Cells to Protect Them Against Alkylating Agents

1997 • 36 citations

Increased resistance to N,N',N"-triethylenethiophosphoramide (thiotepa) in cells expressing the Escherichia coli formamidopyrimidine-DNA glycosylase.

1996 • 32 citations

Interaction of N,N',N''-triethylenethiophosphoramide and N,N',N''-triethylenephosphoramide with cellular DNA.

1991 • 24 citations

Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa

1999 • 24 citations

DNA damage, DNA repair, cell proliferation, and DNA replication: How do gene mutations result?

2000 • 24 citations