Oxidative base damage to DNA: specificity of base excision repair enzymes

Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e- and OH adducts

1989 • 1,215 citations

Hydroxyl radicals and DNA base damage

1999 • 646 citations

Substrate specificity of the Escherichia coli Fpg protein formamidopyrimidine-DNA glycosylase: excision of purine lesions in DNA produced by ionizing radiation or photosensitization

1992 • 597 citations

Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae

1997 • 586 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

Oxidative damage to DNA: Formation, measurement, and biological significance

1997 • 431 citations

Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.

1996 • 352 citations

Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

1997 • 350 citations

Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites.

1990 • 347 citations

New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase.

1994 • 337 citations

Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA

1998 • 330 citations

Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

1994 • 321 citations

DNA N-glycosylases and UV repair

1980 • 307 citations

Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein.

1987 • 285 citations

Substrate specificity of the Escherichia coli endonuclease III: Excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals

1993 • 277 citations

Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III

1997 • 266 citations

Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichla coli

1979 • 257 citations

DNA glycosylase activities for thymine residues damaged by ring saturation, fragmentation, or ring contraction are functions of endonuclease III in Escherichia coli.

1984 • 249 citations

Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene

1989 • 212 citations

A new mechanism for repairing oxidative damage to DNA: (A)BC excinuclease removes AP sites and thymine glycols from DNA

1989 • 177 citations

An endonuclease from Escherichia coli that introduces single polynucleotide chain scissions in ultraviolet-irradiated DNA.

1976 • 172 citations

Isotope dilution high-performance liquid chromatography–electrospray tandem mass spectrometry assay for the measurement of 8-oxo-7,8-dihydro-2′-deoxyguanosine in biological samples

1998 • 171 citations

Kinetics of excision of purine lesions from DNA by Escherichia coli Fpg protein

1997 • 153 citations

Characterization of Escherichia coli Endonuclease VIII

1997 • 152 citations

New trends in photobiology

1993 • 146 citations

Modification of DNA bases by photosensitized one-electron oxidation

1999 • 132 citations

DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli.

1994 • 130 citations

Facts and artifacts in the measurement of oxidative base damage to DNA

1998 • 129 citations

The Catalytic Mechanism of Fpg Protein

1995 • 124 citations

Mechanism of action of a mammalian DNA repair endonuclease

1986 • 120 citations

UvrABC nuclease complex repairs thymine glycol, an oxidative DNA base damage

1990 • 112 citations

Substrate specificity of the Ogg1 protein of Saccharomyces cerevisiae: excision of guanine lesions produced in DNA by ionizing radiation- or hydrogen peroxide/metal ion-generated free radicals

1998 • 111 citations

The Action ofEscherichia coliEndonuclease III on Multiply Damaged Sites in DNA

1995 • 110 citations

Characterization and Chemical Stability of Photooxidized Oligonucleotides that Contain 2,2-Diamino-4-[(2-deoxy-β-<scp>d</scp>-erythro-pentofuranosyl)amino]-5(2H)-oxazolone

1998 • 109 citations

UV-induced pyrimidine hydrates in DNA are repaired by bacterial and mammalian DNA glycosylase activities

1989 • 108 citations

Excision of Products of Oxidative DNA Base Damage by Human NTH1 Protein

1998 • 100 citations

Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical

1998 • 97 citations

Excision of 5,6-Dihydroxy-5,6-dihydrothymine, 5,6-Dihydrothymine, and 5-Hydroxycytosine from Defined Sequence Oligonucleotides by Escherichia coli Endonuclease III and Fpg Proteins: Kinetic and Mechanistic Aspects

1999 • 95 citations

Synthesis and Characterization of Oligonucleotides Containing 5‘,8-Cyclopurine 2‘-Deoxyribonucleosides: (5‘R)-5‘,8-Cyclo-2‘-deoxyadenosine, (5‘S)-5‘,8-Cyclo-2‘-deoxyguanosine, and (5‘R)-5‘,8-Cyclo-2‘-deoxyguanosine

1999 • 89 citations

Enzymatic excision from γ-irradiated polydeoxyribonucleotids of adenine residues whose imidazole rings have been rypture

1984 • 88 citations

Characterization of the effects of a thymine glycol residue on the structure, dynamics, and stability of duplex DNA by NMR.

1993 • 86 citations

Site-Specific Introduction of (5‘S)-5‘,8-Cyclo-2‘-deoxyadenosine into Oligodeoxyribonucleotides

1998 • 79 citations

Sequencing Oligonucleotides by Exonuclease Digestion and Delayed Extraction Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry

1996 • 77 citations

Photodissociation dynamics of C2H2 at 193 nm: Vibrational distributions of the CCH radical and the rotational state distribution of the Ã(010) state by time-resolved Fourier transform infrared emission

1989 • 76 citations

5-Hydroxypyrimidine deoxynucleoside triphosphates are more efficiently incorporated into DNA by exonuclease-free Klenow fragment than 8-oxopurine deoxynucleoside triphosphates

1994 • 73 citations

Synthesis and enzymatic processing of oligodeoxynucleotides containing tandem base damage

1999 • 67 citations

Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry of Chemically Modified Oligonucleotides

1994 • 56 citations

The Ring Fragmentation Product of Thymidine C5-Hydrate When Present in DNA Is Repaired by the Escherichia coli Fpg and Nth Proteins

1998 • 56 citations

2′-Deoxycytidine Glycols, a Missing Link in the Free Radical-mediated Oxidation of DNA

1999 • 52 citations

2 '-deoxycytidine glycols, a missing link in the free radical-mediated oxidation of DNA

1999 • 51 citations

Site-Specific Incorporation of the Alkaline Labile, Oxidative Stress Product (5R)-5,6-Dihydro-5-hydroxythymidine in an Oligonucleotide

1994 • 46 citations

Excision of Oxidative Cytosine Modifications from γ-Irradiated DNA byEscherichia coliEndonuclease III and Human Whole-Cell Extracts

1996 • 43 citations

Substrate Specificity of Schizosaccharomyces pombe Nth Protein for Products of Oxidative DNA Damage

1998 • 40 citations

Synthesis and Biochemical Properties of Cyanuric Acid Nucleoside-Containing DNA Oligomers

1999 • 39 citations

An Improved Method for The Preparation Of The Phosphoramidites Of Modified 2′-Deoxynucleotides: Incorporation Of 8-Oxo-2′-Deoxy-7<u>H</u>-Guanosine Into Synthetic Oligomers

1991 • 38 citations

Synthesis and Thermodynamic Stabilities of Damaged DNA Involving 8-Hydroxyguanine (7,8-Dihydro-8-Oxoguanine) in aras-Gene Fragments

1994 • 36 citations

Synthesis and Kinetic Study of the Deamination of the Cis Diastereomers of 5,6-Dihydroxy-5,6-dihydro-5-methyl-2‘-deoxycytidine

1996 • 35 citations

Synthesis and Cleavage of Oligodeoxynucleotides Containing a 5-Hydroxyuracil Residue at a Defined Site

1997 • 34 citations

Kinetics of Oxidized Cytosine Repair by Endonuclease III of Escherichia coli

1997 • 32 citations

RETRACTED: The yeast RAD2, but not RAD1, gene is involved in the transcription-coupled repair of thymine glycols

1995 • 32 citations

Synthesis and Characterization of DNA Fragments Bearing an Adenine Radiation Product: 7,8‐Dihydroadenin‐8‐one

1988 • 29 citations

A Convenient Synthesis of 5-Hydroxy-2′-Deoxycytidine Phosphoramidite and its Incorporation into Oligonucleotides

1997 • 28 citations

Substrate Specificity of Deinococcus radiodurans Fpg Protein

1999 • 26 citations

Incorporation by chemical synthesis and characterization of deoxyribosylformylamine into DNA

1991 • 25 citations

Synthesis of Oligonucleotides Containing Two Putatively Mutagenic DNA Lesions: 5-Hydroxy-2‘-deoxyuridine and 5-Hydroxy-2‘-deoxycytidine

1997 • 20 citations

Synthesis of Oligonucleotides Containing the (4R) and (4S) Diastereoisomers of 4,8-Dihydro-4-hydroxy-8-oxo-2′-deoxyguanosine

1999 • 14 citations

Gas chromatography–mass spectrometry with high-performance liquid chromatography prepurification for monitoring the endonuclease III-mediated excision of 5-hydroxy-5,6-dihydrothymine and 5,6-dihydrothymine from γ-irradiated DNA

1998 • 12 citations

Excision of 7,8-dihydro-8-oxoguanine from DNA by the Fpg protein

1993 • 11 citations

The effects of the ring fragmentation product of thymidine C5-hydrate on phosphodiestrases and klenow (exo^-)fragment

1995 • 11 citations

Properties of DNA Duplexes Containing an Abasic Site: Effect of Nucleotide Residue of the Opposite Part of a 2-Deoxyribosylformamide Residue

1994 • 11 citations

Deleted Work

1955 • 0 citations

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