Stat1-Dependent, p53-Independent Expression of p21^waf1 Modulates Oxysterol-Induced Apoptosis

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

1997 • 1,642 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.

1997 • 855 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Bypass of Senescence After Disruption of p21 ^CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

1997 • 797 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

The oxidative modification hypothesis of atherogenesis: an overview

2000 • 749 citations

The p53 Network

1998 • 731 citations

Apoptosis in Human Atherosclerosis and Restenosis

1995 • 684 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma.

1996 • 557 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

1999 • 481 citations

Vitamin E and heart disease:

2000 • 456 citations

Atherosclerosis and Coronary Artery Disease

1996 • 438 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Effects of p21^{Waf1/Cip1/Sdi1}on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

2000 • 426 citations

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.

1994 • 410 citations

Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

1989 • 373 citations

Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases

1997 • 373 citations

Exogenous Interferon-γ Enhances Atherosclerosis in Apolipoprotein E−/− Mice

2000 • 361 citations

Current protocols in immunology

1992 • 356 citations

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B

1997 • 353 citations

How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene

2000 • 337 citations

Apoptosis in the vasculature: mechanisms and functional importance

2000 • 327 citations

Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells.

2001 • 317 citations

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

1997 • 305 citations

The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo

1999 • 278 citations

Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

1995 • 247 citations

7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque

1997 • 240 citations

Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation

1994 • 234 citations

Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis

1998 • 215 citations

Glutathione is implied in the control of 7‐ketocholesterol‐induced apoptosis, which is associated with radical oxygen species production

1998 • 215 citations

Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis

2000 • 208 citations

Characterization and Comparison of the Mode of Cell Death, Apoptosis Versus Necrosis, Induced by 7β-Hydroxycholesterol and 7-Ketocholesterol in the Cells of the Vascular Wall

1999 • 196 citations

Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studiesin vivoandin vitro

1999 • 180 citations

Induction of Apoptosis and Fas Receptor/Fas Ligand Expression by Ischemia/Reperfusion in Cardiac Myocytes Requires Serine 727 of the STAT-1 Transcription Factor but Not Tyrosine 701

2001 • 175 citations

The Oxidation of Lipoproteins by Monocytes-Macrophages

1999 • 172 citations

Induction of apoptosis in endothelial cells treated with cholesterol oxides.

1996 • 167 citations

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents

2001 • 163 citations

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

1990 • 162 citations

Stat1 Serine Phosphorylation Occurs Independently of Tyrosine Phosphorylation and Requires an Activated Jak2 Kinase

1997 • 155 citations

Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome.

1996 • 148 citations

Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons.

1991 • 147 citations

Oxysterols Induced Apoptosis in Cultured Smooth Muscle Cells through CPP32 Protease Activation and bcl-2 Protein Downregulation

1996 • 145 citations

STAT1 Affects Lymphocyte Survival and Proliferation Partially Independent of Its Role Downstream of IFN-γ

2000 • 144 citations

Varying susceptibility of different low density lipoproteins to oxidative modification.

1991 • 140 citations

Oxidized Lipids in Atherogenesis: Formation, Destruction and Action

1997 • 136 citations

Different patterns of IL‐1β secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7α‐, 7β‐hydroxycholesterol, or 7‐ketocholesterol

1998 • 122 citations

Oxidized LDL Induces Apoptosis in Cultured Smooth Muscle Cells: A Possible Role for 7-Ketocholesterol

1996 • 115 citations

In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals.

1995 • 112 citations

Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication

2000 • 111 citations

Adenovirus-Mediated p21 ^{(WAF1/SDII/CIP1)} Gene Transfer Induces Apoptosis of Human Cervical Cancer Cell Lines

1999 • 104 citations

Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells: accumulation of oxidized esters in lysosomes

2000 • 103 citations

Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol

1996 • 100 citations

Distinct Roles for STAT1, STAT3, and STAT5 in Differentiation Gene Induction and Apoptosis Inhibition by Interleukin-9

1999 • 92 citations

Thrombin Inhibits Tumor Cell Growth in Association with Up-regulation of p21 and Caspases via a p53-independent, STAT-1-dependent Pathway

2000 • 88 citations

Collaborative role of E2F transcriptional activity and G ₁ cyclindependent kinase activity in the induction of S phase

1999 • 84 citations

Chromium(VI) Induces p53-Dependent Apoptosis in Diploid Human Lung and Mouse Dermal Fibroblasts

2000 • 84 citations

7-Ketocholesterol

1999 • 83 citations

Induction of apoptosis and of interleukin‐1β secretion by 7β‐hydroxycholesterol and 7‐ketocholesterol: partial inhibition by Bcl‐2 overexpression

1997 • 83 citations

Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol

1997 • 68 citations

Bcl‐2 protein inhibits oxysterol‐induced apoptosis through suppressing CPP32‐mediated pathway

1997 • 65 citations

STAT-1-Independent Upregulation of FADD and Procaspase-3 and -8 in Cancer Cells Treated with Cytotoxic Drugs

1999 • 63 citations

Activity and nature of p21 ^WAF1 complexes during the cell cycle

1998 • 61 citations

The induction of apoptosis in proliferating human fibroblasts by oxygen radicals is associated with a p53‐ and p21^WAF1CIP1 induction

1997 • 56 citations

STATs as activators of apoptosis

1998 • 51 citations

Loss of STAT1 expression confers resistance to IFN‐γ‐induced apoptosis in ME180 cells

1999 • 47 citations

Immunological control mechanisms in plaque formation

1994 • 32 citations

Cytotoxicity of Some Oxysterols on Human Vascular Smooth Muscle Cells was mediated by apoptosis

1997 • 32 citations

Involvement of pRB-related p107 Protein in the Inhibition of S Phase Progression in Response to Genotoxic Stress

2001 • 23 citations

3.P.159 Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells

1997 • 22 citations

Detection of apoptotic cells by selective precipitation of [3H]thymidine-labelled DNA

1996 • 5 citations