STAT1 Affects Lymphocyte Survival and Proliferation Partially Independent of Its Role Downstream of IFN-γ

Apoptosis by Death Factor

1997 • 5,038 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

1999 • 1,410 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 • 843 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE

1998 • 687 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis

1997 • 525 citations

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

1997 • 508 citations

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis

1995 • 422 citations

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

1999 • 375 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

The neglected role of type I interferon in the T-cell response: implications for its clinical use

1996 • 306 citations

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.

1994 • 305 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction

1997 • 275 citations

Transplantation of discordant xenografts: a challenge revisited

1996 • 257 citations

Bclx regulates the survival of double-positive thymocytes.

1995 • 249 citations

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G₀ Cell State From a G₁ Cell State

1996 • 222 citations

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1996 • 178 citations

Stat5 Activation Is Uniquely Associated with Cytokine Signaling in Peripheral T Cells

1999 • 171 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Caspase-14 Is a Novel Developmentally Regulated Protease

1998 • 153 citations

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.

1993 • 140 citations

Stat Proteins Control Lymphocyte Proliferation by Regulating p27^Kip1 Expression

1998 • 133 citations

Regulation of Interferon-α Responsiveness by the Duration of Janus Kinase Activity

1997 • 94 citations

Inactivation of a Cdk2 Inhibitor during Interleukin 2-Induced Proliferation of Human T Lymphocytes

1994 • 94 citations

Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis

1998 • 72 citations

Differential Regulation of Constitutive Major Histocompatibility Complex Class I Expression in T and B Lymphocytes

1999 • 71 citations

Interferon-alpha inhibits proliferation in human T lymphocytes by abrogation of interleukin 2-induced changes in cell cycle-regulatory proteins.

1999 • 52 citations

Molecular Regulation of Cytokine Gene Expression: lnterferon-γ as a Model System

1997 • 32 citations

Lessons from Immunological, Biochemical, and Molecular Pathways of the Activation Mediated by IL-2 and IL-4

1996 • 31 citations

An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis.

1994 • 30 citations