Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation

Photochemically generated cytosolic calcium pulses and their detection by fluo-3

1989 • 820 citations

Alpha-toxin of Staphylococcus aureus

1991 • 758 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

On the mechanism of membrane damage by Staphylococcus aureus alpha-toxin.

1981 • 369 citations

Ionic channels formed byStaphylococcus aureus alpha-toxin: Voltage-dependent inhibition by divalent and trivalent cations

1986 • 349 citations

Ionophore-induced apoptosis: Role of DNA fragmentation and calcium fluxes

1991 • 235 citations

A guide to the use of pore-forming toxins for controlled permeabilization of cell membranes

1993 • 232 citations

Interactions between membranes and cytolytic bacterial toxins

1974 • 225 citations

Pro‐oxidants and mitochondrial Ca²⁺: their relationship to apoptosis and oncogenesis

1993 • 218 citations

Volume-induced increase of anion permeability in human lymphocytes.

1982 • 202 citations

Staphylococcus aureus alpha-toxin. Dual mechanism of binding to target cells.

1991 • 195 citations

Flow cytometric measurement of cytoplasmic free calcium in human peripheral blood T lymphocytes with fluo-3, a new fluorescent calcium indicator

1990 • 184 citations

Release of interleukin-1 beta associated with potent cytocidal action of staphylococcal alpha-toxin on human monocytes

1989 • 165 citations

Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions

1993 • 163 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

Secondary structure and assembly mechanism of an oligomeric channel protein

1985 • 160 citations

Assembly of the oligomeric membrane pore formed by Staphylococcal alpha-hemolysin examined by truncation mutagenesis.

1992 • 156 citations

Minimal requirements for exocytosis. A study using PC 12 cells permeabilized with staphylococcal alpha-toxin.

1985 • 154 citations

Staphylococcal α toxin promotes blood coagulation via attack on human platelets

1988 • 126 citations

Cytolysis by Ca-permeable transmembrane channels. Pore formation causes extensive DNA degradation and cell lysis.

1989 • 105 citations

Studies on the binding of staphylococcal 125I-labeled α-toxin to rabbit erythrocytes

1976 • 96 citations

Mechanism of leukotriene generation in polymorphonuclear leukocytes by staphylococcal alpha-toxin

1987 • 77 citations

Cytocidal effects of Escherichia coli hemolysin on human T lymphocytes

1993 • 75 citations

Pore formation by Staphylococcus aureus alpha-toxin in lipid bilayers

1987 • 71 citations

Superoxide generation by human neutrophils induced by low doses of Escherichia coli hemolysin

1991 • 70 citations

22Na+ fluxes in thymic lymphocytes. I. Na+/Na+ and Na+/H+ exchange through an amiloride-insensitive pathway.

1984 • 66 citations

Lack of DNA degradation in target cells lysed by granules derived from cytolytic T lymphocytes.

1988 • 48 citations

Staphylococcus aureus alpha-toxin. Production of functionally intact, site-specifically modifiable protein by introduction of cysteine at positions 69, 130, and 186

1993 • 44 citations

Interaction of the alpha-toxin of Staphylococcus aureus with the liposome membrane.

1987 • 24 citations