Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells: accumulation of oxidized esters in lysosomes

Beyond Cholesterol

1989 • 6,533 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Biochemistry and pathology of radical-mediated protein oxidation

1997 • 1,675 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

1994 • 1,300 citations

Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine

1984 • 689 citations

Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts

1989 • 509 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Human Atherosclerotic Plaque Contains Both Oxidized Lipids and Relatively Large Amounts of α-Tocopherol and Ascorbate

1995 • 357 citations

α-tocopherol consumption during low-density-lipoprotein oxidation

1990 • 312 citations

Autoxidation of unsaturated lipids

1986 • 279 citations

Reactive species and their accumulation on radical-damaged proteins

1993 • 253 citations

Autoxidation of unsaturated lipids

1988 • 229 citations

A Method for Defining the Stages of Low-Density Lipoprotein Oxidation by the Separation of Cholesterol and Cholesteryl Ester-Oxidation Products Using HPLC

1993 • 221 citations

A purified plasma membrane fraction isolated from rat liver under isotonic conditions

1967 • 192 citations

The Hydrolysis of Long-chain Fatty Acid Esters of Cholesterol with Rat Liver Enzymes

1962 • 182 citations

Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages

1996 • 179 citations

Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages.

1990 • 162 citations

Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes.

1986 • 149 citations

Oxidized low density lipoprotein is resistant to cathepsins and accumulates within macrophages

1991 • 147 citations

Sterol Efflux Is Impaired from Macrophage Foam Cells Selectively Enriched with 7-Ketocholesterol

1996 • 130 citations

The intracellular storage and turnover of apolipoprotein B of oxidized LDL in macrophages

1992 • 124 citations

Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?

1998 • 119 citations

Inactivation of lysosomal proteases by oxidized low density lipoprotein is partially responsible for its poor degradation by mouse peritoneal macrophages.

1994 • 115 citations

Characterization of lipid-laden aortic cells from cholesterol-fed rabbits. III. Intracellular localization of cholesterol and cholesteryl ester.

1979 • 115 citations

(Carboxyalkyl)pyrroles in Human Plasma and Oxidized Low-Density Lipoproteins

1997 • 107 citations

Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions

1997 • 99 citations

Apolipoprotein A-I–Mediated Efflux of Sterols From Oxidized LDL–Loaded Macrophages

1995 • 96 citations

Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester.

1994 • 83 citations

Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species

1998 • 78 citations

Structural identification of valine hydroperoxides and hydroxides on radical-damaged amino acid, peptide, and protein molecules

1995 • 77 citations

Macrophage Uptake of Oxidized LDL Inhibits Lysosomal Sphingomyelinase, Thus Causing the Accumulation of Unesterified Cholesterol–Sphingomyelin–Rich Particles in the Lysosomes

1995 • 73 citations

Uptake of Oxidized LDL by Macrophages Differs From That of Acetyl LDL and Leads to Expansion of an Acidic Endolysosomal Compartment

1999 • 73 citations

5-Lipoxygenase is not essential in macrophage-mediated oxidation of low-density lipoprotein

1991 • 69 citations

Mononuclear phagocytes; physiology and pathology

1986 • 68 citations

Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein.

1989 • 64 citations

Apolipoprotein B of oxidized LDL accumulates in the lysosomes of macrophages

1994 • 63 citations

Accelerated endocytosis and incomplete catabolism of radical-damaged protein

1992 • 56 citations

Oxidized LDL increase free cholesterol and fail to stimulate cholesterol esterification in murine macrophages

1990 • 51 citations

Oxidation of Low-Density Lipoproteins Produces Levuglandin-Protein Adducts

1997 • 50 citations

Inefficient Degradation of Oxidized Regions of Protein Molecules

1993 • 49 citations

Inactivation of Cathepsin B by Oxidized LDL Involves Complex Formation Induced by Binding of Putative Reactive Sites Exposed at Low pH to Thiols on the Enzyme

1997 • 48 citations

Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid

1999 • 47 citations

Interaction of 4-hydroxynonenal-modified low-density lipoproteins with the fibroblast apolipoprotein B/E receptor

1986 • 45 citations

Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells

1993 • 44 citations

Cholesterol deposition in macrophages: foam cell formation mediated by cholesterol-enriched oxidized low density lipoprotein.

1997 • 43 citations

Mononuclear phagocytes : physiology and pathology

1985 • 36 citations

Batch-To-Batch Variation of Chelex-100 Confounds Metal-Catalysed Oxidation. Leaching of Inhibitory Compounds from A Batch of Chelex-100 and Their Removal by a Pre-Washing Procedure

1995 • 35 citations

Rapid subcellular fractionation of the rat liver endocytic compartments involved in transcytosis of polymeric immunoglobulin A and endocytosis of asialofetuin

1987 • 29 citations

Femtomole analysis of 9-oxononanoyl cholesterol by high performance liquid chromatography

1998 • 29 citations

Cholesteryl Ester Accumulation in Macropbages Treated with Oxidized Low Density Lipoprotein

1995 • 28 citations

Accumulation and metabolism of low density lipoprotein-derived cholesteryl linoleate hydroperoxide and hydroxide by macrophages

1998 • 21 citations

Deleted Work

1955 • 0 citations