Adjusting the focus on human variation

Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.

1989 • 13,216 citations

EVOLUTION IN MENDELIAN POPULATIONS

1931 • 8,698 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Population growth makes waves in the distribution of pairwise genetic differences.

1992 • 4,603 citations

Evolutionary Rate at the Molecular Level

1968 • 3,608 citations

The hitch-hiking effect of a favourable gene

1974 • 3,276 citations

Mitochondrial DNA and human evolution

1987 • 2,967 citations

The hitch-hiking effect of a favourable gene

2007 • 2,840 citations

Hudson et al.

1977 • 2,560 citations

Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations.

1991 • 2,351 citations

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? 1962.

1999 • 2,323 citations

Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome

1998 • 2,163 citations

High resolution of human evolutionary trees with polymorphic microsatellites

1994 • 1,868 citations

The effect of deleterious mutations on neutral molecular variation.

1993 • 1,838 citations

THE INTERACTION OF SELECTION AND LINKAGE. I. GENERAL CONSIDERATIONS; HETEROTIC MODELS

1964 • 1,829 citations

The effect of linkage on limits to artificial selection

1966 • 1,822 citations

A Test of Neutral Molecular Evolution Based on Nucleotide Data

1987 • 1,789 citations

The effect of linkage on limits to artificial selection

2007 • 1,640 citations

STATISTICAL PROPERTIES OF THE NUMBER OF RECOMBINATION EVENTS IN THE HISTORY OF A SAMPLE OF DNA SEQUENCES

1985 • 1,603 citations

Characterization of single-nucleotide polymorphisms in coding regions of human genes

1999 • 1,531 citations

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

1999 • 1,453 citations

The DNA sequence of human chromosome 21

2000 • 1,406 citations

The DNA sequence of human chromosome 22

1999 • 1,167 citations

Variations on a Theme: Cataloging Human DNA Sequence Variation

1997 • 1,064 citations

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

1999 • 1,023 citations

Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster

1992 • 987 citations

An STS-Based Map of the Human Genome

1995 • 782 citations

NATURAL SELECTION AT MAJOR HISTOCOMPATIBILITY COMPLEX LOCI OF VERTEBRATES

1998 • 667 citations

The hitchhiking effect on the site frequency spectrum of DNA polymorphisms.

1995 • 620 citations

Low nucleotide diversity in man.

1991 • 501 citations

The use of a genetic map of biallelic markers in linkage studies

1997 • 499 citations

Sequence variation in the human angiotensin converting enzyme

1999 • 490 citations

Haplotype Structure and Population Genetic Inferences from Nucleotide-Sequence Variation in Human Lipoprotein Lipase

1998 • 439 citations

The coalescent process in models with selection and recombination.

1988 • 434 citations

Archaic African and Asian lineages in the genetic ancestry of modern humans.

1997 • 415 citations

High genomic deleterious mutation rates in hominids

1999 • 405 citations

Detection of the Signature of Natural Selection in Humans: Evidence from the Duffy Blood Group Locus

2000 • 352 citations

THE RATE OF MOLECULAR EVOLUTION CONSIDERED FROM THE STANDPOINT OF POPULATION GENETICS

1969 • 298 citations

High Polymorphism at the Human Melanocortin 1 Receptor Locus

1999 • 289 citations

Nonequilibrium Migration in Human History

1999 • 266 citations

Genetic evidence for a Paleolithic human population expansion in Africa

1998 • 246 citations

Signatures of Population Expansion in Microsatellite Repeat Data

1998 • 244 citations

DNA sequence variation in a non-coding region of low recombination on the human X chromosome

1999 • 242 citations

X chromosome evidence for ancient human histories

1999 • 229 citations

DNA Variability and Recombination Rates at X-Linked Loci in Humans

1998 • 204 citations

Minisatellite diversity supports a recent African origin for modern humans

1996 • 174 citations

Heterogeneity of Microsatellite Mutations Within and Between Loci, and Implications for Human Demographic Histories

1998 • 158 citations

Mitochondrial and nuclear genes present conflicting portraits of human origins

1997 • 139 citations

When Did the Human Population Size Start Increasing?

2000 • 138 citations

Detecting Ancient Admixture in Humans Using Sequence Polymorphism Data

2000 • 119 citations

The neutralist, the fly and the selectionist

1999 • 116 citations

Evidence for Heterogeneity in Recombination in the Human Pseudoautosomal Region: High Resolution Analysis by Sperm Typing and Radiation-Hybrid Mapping

2000 • 115 citations

Genetic Structure of the Ancestral Population of Modern Humans

1998 • 102 citations

DNA polymorphism in a subdivided population: the expected number of segregating sites in the two-subpopulation model.

1989 • 89 citations

Contrasting Evolutionary Histories of Two Introns of the Duchenne Muscular Dystrophy Gene, Dmd, in Humans

2000 • 72 citations

Spatial and Temporal Distribution of the Neutral Polymorphisms in the Last ZFX Intron: Analysis of the Haplotype Structure and Genealogy

1999 • 65 citations

Junk ain't what junk does: neutral alleles in a selected context

1997 • 57 citations

Is selection responsible for the low level of variation in the last intron of the ZFY locus?

1999 • 41 citations

Microsatellite Mutations and Inferences About Human Demography

2000 • 39 citations