Protein Crosslinking in Assembly and Remodelling of Extracellular Matrices: The Role of Transglutaminases

Identification of tissue transglutaminase as the autoantigen of celiac disease

1997 • 2,028 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

1998 • 1,158 citations

Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function

1995 • 900 citations

The ɛ-(γ-Glutamyl)Lysine Crosslink and the Catalytic Role of Transglutaminases

1977 • 813 citations

Transglutaminases

1984 • 589 citations

G _h : a GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function

1994 • 550 citations

Cell Membrane Resealing by a Vesicular Mechanism Similar to Neurotransmitter Release

1994 • 522 citations

New strategy for chemical modification of hyaluronic acid: Preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels

1999 • 521 citations

The Proteins Elafin, Filaggrin, Keratin Intermediate Filaments, Loricrin, and Small Proline-rich Proteins 1 and 2 Are Isodipeptide Cross-linked Components of the Human Epidermal Cornified Cell Envelope

1995 • 508 citations

Transglutaminases: Protein Cross-Linking Enzymes in Tissues and Body Fluids

1994 • 504 citations

Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity.

1998 • 487 citations

NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival

1998 • 484 citations

Mutations of Keratinocyte Transglutaminase in Lamellar Ichthyosis

1995 • 480 citations

Cell migration: regulation of force on extracellular-matrix-integrin complexes

1998 • 443 citations

Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity

1998 • 406 citations

Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

1997 • 397 citations

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch

1998 • 360 citations

Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis

1995 • 359 citations

Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII.

1994 • 343 citations

Cross-Linking Exogenous Bifunctional Peptides into Fibrin Gels with Factor XIIIa

1998 • 306 citations

Superfibronectin is a functionally distinct form of fibronectin

1994 • 300 citations

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells.

1993 • 290 citations

Autoantibodies in coeliac disease: tissue transglutaminase—guilt by association?

1997 • 287 citations

Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

1998 • 281 citations

Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis

1999 • 250 citations

Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: effects on cellular morphology and adhesion.

1992 • 234 citations

Differential expression of tissue transglutaminase in human cells

1989 • 226 citations

Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers.

1982 • 219 citations

S100A11, S100A10, Annexin I, Desmosomal Proteins, Small Proline-rich Proteins, Plasminogen Activator Inhibitor-2, and Involucrin Are Components of the Cornified Envelope of Cultured Human Epidermal Keratinocytes

1997 • 216 citations

Novel Aspects of Blood Coagulation Factor XIII. I. Structure, Distribution, Activation, and Function

1996 • 206 citations

Cross-linking of laminin-nidogen complexes by tissue transglutaminase. A novel mechanism for basement membrane stabilization

1991 • 201 citations

Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: Relevance to diseases of the nervous system

1996 • 200 citations

Direct Evidence That Involucrin Is a Major Early Isopeptide Cross-linked Component of the Keratinocyte Cornified Cell Envelope

1997 • 200 citations

Transglutaminase Action Imitates Huntington's Disease: Selective Polymerization of Huntingtin Containing Expanded Polyglutamine

1998 • 200 citations

Lysophosphatidic acid and microtubule-destabilizing agents stimulate fibronectin matrix assembly through Rho-dependent actin stress fiber formation and cell contraction.

1997 • 197 citations

Synthesis and Characterization of Enzymatically-Cross-Linked Poly(ethylene glycol) Hydrogels

1997 • 196 citations

Factor XIII: Inherited and acquired deficiency

1993 • 193 citations

A Novel Go-mediated Phototransduction Cascade in Scallop Visual Cells

1997 • 182 citations

Transglutaminase-catalyzed matrix cross-linking in differentiating cartilage: identification of osteonectin as a major glutaminyl substrate.

1995 • 182 citations

Evidence That Phospholipase δ1 Is the Effector in the Gh (Transglutaminase II)-mediated Signaling

1996 • 180 citations

Expression of tissue transglutaminase in skeletal tissues correlates with events of terminal differentiation of chondrocytes.

1993 • 179 citations

Transglutaminase activity is increased in Alzheimer's disease brain

1997 • 177 citations

`Tissue' transglutaminase in cell death: a downstream or a multifunctional upstream effector?

1998 • 171 citations

Localization of cellular transglutaminase on the extracellular matrix after wounding: Characteristics of the matrix bound enzyme

1991 • 163 citations

Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis

1991 • 162 citations

A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB

1997 • 159 citations

Reduced expression of tissue transglutaminase in a human endothelial cell line leads to changes in cell spreading, cell adhesion and reduced polymerisation of fibronectin

1997 • 151 citations

Regulated Expression of Tissue Transglutaminase in Swiss 3T3 Fibroblasts: Effects on the Processing of Fibronectin, Cell Attachment, and Cell Death

1998 • 150 citations

Developmental roles of the retinoic acid receptors

1995 • 149 citations

Transglutaminase factor XIII uses proteinase‐like catalytic triad to crosslink macromolecules

1994 • 140 citations

Cross-linking of alpha 2-plasmin inhibitor to fibrin catalyzed by activated fibrin-stabilizing factor.

1982 • 138 citations

Cell Surface Localization of Tissue Transglutaminase Is Dependent on a Fibronectin-binding Site in Its N-terminal β-Sandwich Domain

1999 • 132 citations

Role of fibronectin in the migration of fibroblasts into plasma clots.

1986 • 127 citations

The role of transglutaminase in the rat subtotal nephrectomy model of renal fibrosis.

1997 • 125 citations

A Transglutaminase That Converts Interleukin-2 into a Factor Cytotoxic to Oligodendrocytes

1993 • 125 citations

Biogenesis of the Saccharomyces cerevisiae Mating Pheromone a-Factor

1997 • 125 citations

Covalent Cross-linking of Fibronectin to Fibrin Is Required for Maximal Cell Adhesion to a Fibronectin-Fibrin Matrix

1997 • 124 citations

Identification and Characterization of a Versatile Retinoid Response Element (Retinoic Acid Receptor Response Element-Retinoid X Receptor Response Element) in the Mouse Tissue Transglutaminase Gene Promoter

1996 • 124 citations

Evidence for the Involvement of Retinoic Acid Receptor RARα-dependent Signaling Pathway in the Induction of Tissue Transglutaminase and Apoptosis by Retinoids

1995 • 120 citations

The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse

1993 • 117 citations

Highly Active Soluble Processed Forms of the Transglutaminase 1 Enzyme in Epidermal Keratinocytes

1995 • 117 citations

Dimerization of Midkine by Tissue Transglutaminase and Its Functional Implication

1997 • 115 citations

Interaction Site of GTP Binding Gh (Transglutaminase II) with Phospholipase C

1995 • 114 citations

Recovery of Visual Response of Injured Adult Rat Optic Nerves Treated with Transglutaminase

1994 • 110 citations

Tissue (type II) transglutaminase covalently incorporates itself, fibrinogen, or fibronectin into high molecular weight complexes on the extracellular surface of isolated hepatocytes. Use of 2-[(2-oxopropyl)thio] imidazolium derivatives as cellular transglutaminase inactivators.

1991 • 109 citations

Essential Roles of Retinoic Acid Signaling in Interdigital Apoptosis and Control of BMP-7 Expression in Mouse Autopods

1999 • 109 citations

Transglutaminase-mediated processing of fibronectin by endothelial cell monolayers

1994 • 108 citations

Factor XIII‐mediated cross‐linking of NH₂‐terminal peptide of α2‐plasmin inhibitor to fibrin

1983 • 107 citations

Transglutaminase induction by various cell death and apoptosis pathways

1996 • 107 citations

Transglutaminase-catalyzed crosslinking of fibrils of collagen V/XI in A204 rhabdomyosarcoma cells

1995 • 107 citations

Identification of Cytoplasmic Actin as an Abundant Glutaminyl Substrate for Tissue Transglutaminase in HL-60 and U937 Cells Undergoing Apoptosis

1997 • 106 citations

Transglutaminase II: A New Class of GTP-Binding Protein with New Biological Functions

1997 • 105 citations

α1-Adrenergic Receptor Signaling via Gh Is Subtype Specific and Independent of Its Transglutaminase Activity

1996 • 104 citations

Tissue Transglutaminase and Factor XIII in Cartilage and Bone Remodeling

1996 • 104 citations

Identification of Gln726 in nidogen as the amine acceptor in transglutaminase-catalyzed cross-linking of laminin-nidogen complexes.

1992 • 102 citations

Alignment of Fibrillin Molecules in Elastic Microfibrils Is Defined by Transglutaminase-Derived Cross-Links

1997 • 102 citations

Activator Protein 1 Activity Is Involved in the Regulation of the Cell Type-specific Expression from the Proximal Promoter of the Human Profilaggrin Gene

1996 • 100 citations

Cardiac Specific Overexpression of Transglutaminase II (Gh) Results in a Unique Hypertrophy Phenotype Independent of Phospholipase C Activation

1999 • 99 citations

Cross-linking of the dermo-epidermal junction of skin regenerating from keratinocyte autografts. Anchoring fibrils are a target for tissue transglutaminase.

1996 • 99 citations

Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and α-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length

1997 • 96 citations

Isolation and Characterization of the Human Tissue Transglutaminase Gene Promoter

1995 • 94 citations

Retinoic Acid Receptor α Function in Vertebrate Limb Skeletogenesis: a Modulator of Chondrogenesis

1997 • 94 citations

Expression induced by interleukin-6 of tissue-type transglutaminase in human hepatoblastoma HepG2 cells.

1993 • 93 citations

Isolation of a cDNA Encoding a Novel Member of the Transglutaminase Gene Family from Human Keratinocytes

1998 • 92 citations

Transglutaminase Catalyzes the Formation of Sodium Dodecyl Sulfate‐Insoluble, Alz‐50‐Reactive Polymers of τ

1993 • 92 citations

Identification of a Transforming Growth Factor-β1/Bone Morphogenetic Protein 4 (TGF-β1/BMP4) Response Element within the Mouse Tissue Transglutaminase Gene Promoter

1998 • 91 citations

TNF-α modulates expression of the tissue transglutaminase gene in liver cells

1998 • 91 citations

Differential modulation of cell adhesion by interaction between adhesive and counter-adhesive proteins: characterization of the binding of vitronectin to osteonectin (BM40, SPARC)

1997 • 90 citations

Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase

1996 • 88 citations

Assembly of Fibronectin into Extracellular Matrix

1991 • 84 citations

The Transglutaminase 1 Enzyme Is Variably Acylated by Myristate and Palmitate during Differentiation in Epidermal Keratinocytes

1996 • 84 citations

The Cutaneous Microfibrillar Apparatus Contains Latent Transforming Growth Factor-β Binding Protein-1 (LTBP-1) and is a Repository for Latent TGF-β1

1998 • 83 citations

Transglutaminase Cross-linking Properties of the Small Proline-rich 1 Family of Cornified Cell Envelope Proteins

1999 • 83 citations

A New Biological Glue for Cartilage-Cartilage Interfaces

1997 • 82 citations

Expression of SPARC in normal and fibrotic livers

1995 • 81 citations

Activation of retinoid receptors RAR alpha and RXR alpha induces differentiation and apoptosis, respectively, in HL-60 cells.

1996 • 80 citations

Human erythrocyte membrane protein band 4.2 (pallidin).

1993 • 79 citations

The Fibronectin-binding Domain of Transglutaminase

1995 • 77 citations

The Core Domain of the Tissue Transglutaminase G_h Hydrolyzes GTP and ATP

1997 • 77 citations

Hydrolysis of γ:ϵ Isopeptides by Cytosolic Transglutaminases and by Coagulation Factor XIIIa

1997 • 77 citations

Expression of Retinoic Acid Nuclear Receptors and Tissue Transglutaminase Is Altered in Various Tissues of Rats Fed a Vitamin A-Deficient Diet

1992 • 76 citations

Cross‐linking of galectin 3, a galactose‐binding protein of mammalian cells, by tissue‐type transglutaminase

1995 • 72 citations

Tissue-specific and androgen-regulated expression of human prostate-specific transglutaminase

1996 • 71 citations

Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase

1996 • 70 citations

The Enzymatic Deamidation of Proteins

1960 • 70 citations

Immunoelectrophoretic characterizations of the cross-linking of fibrinogen and fibrin by factor XIIIa and tissue transglutaminase. Identification of a rapid mode of hybrid alpha-/gamma-chain cross-linking that is promoted by the gamma-chain cross-linking.

1991 • 66 citations

Post-translational Modification of CD38 Protein into a High Molecular Weight Form Alters Its Catalytic Properties

1996 • 65 citations

Fibrin sealant

1996 • 65 citations

Regulation of the expression of the tissue transglutaminase gene by DNA methylation

1997 • 65 citations

Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells.

1997 • 64 citations

Tissue transglutaminase expression in human breast cancer.

1996 • 63 citations

Dual functions of transglutaminase in novel cell adhesion

1996 • 62 citations

Two Adjacent N-terminal Glutamines of BM-40 (Osteonectin, SPARC) Act as Amine Acceptor Sites in TransglutaminaseC-catalyzed Modification

1995 • 61 citations

A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.

1994 • 60 citations

Transfection of tissue transglutaminase into a highly malignant hamster fibrosarcoma leads to a reduced incidence of primary tumour growth.

1994 • 59 citations

Labeling of epsilon-lysine crosslinking sites in proteins with peptide substrates of factor XIIIa and transglutaminase.

1990 • 58 citations

Immunoelectrophoretic and immunohistochemical characterizations of fibrinogen derivatives in atherosclerotic aortic intimas and vascular prosthesis pseudo-intimas.

1992 • 58 citations

Plasma Transglutaminase in Hypertrophic Chondrocytes: Expression and Cell-specific Intracellular Activation Produce Cell Death and Externalization

1998 • 55 citations

The promoter of the mouse tissue transglutaminase gene directs tissue-specific, retinoid-regulated and apoptosis-linked expression

1997 • 55 citations

Protein Cross-linking Mediated by Tissue Transglutaminase Correlates with the Maturation of Extracellular Matrices During Lung Development

1997 • 53 citations

Visualization of purified fibronectin-transglutaminase complexes.

1992 • 52 citations

Structure and Function Studies of Factor XIIIa by x-ray Crystallography

1996 • 52 citations

Fibrinogen and fibrin polymerization

1997 • 50 citations

Cross-linking of the NH2-terminal Region of Fibronectin to Molecules of Large Apparent Molecular Mass:

1996 • 50 citations

The Intermediate Filament Protein, Vimentin, in the Lens Is a Target for Cross-linking by Transglutaminase

1998 • 49 citations

Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells

1996 • 49 citations

Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly.

1997 • 49 citations

Cellular transglutaminases in neural development

1993 • 48 citations

Modulation of Cellular Response to Antigens by Uteroglobin and Transglutaminase

1988 • 47 citations

The transglutaminase in vascular cells and tissues could provide an alternate pathway for fibrin stabilization

1987 • 47 citations

Genes Up-Regulated in Hypertrophied Ventricle

1995 • 47 citations

Lipoprotein (a) is a substrate for factor XIIIa and tissue transglutaminase.

1991 • 46 citations

Rescue of the limb deformity in Hammertoe mutant mice by retinoic acid-induced cell death

1997 • 45 citations

Site-Specific Modification of Interleukin-2 by the Combined Use of Genetic Engineering Techniques and Transglutaminase

1996 • 45 citations

Calreticulin Down-Regulates both GTP Binding and Transglutaminase Activities of Transglutaminase II

1999 • 45 citations

Purification and characterization of a novel zinc-proteinase from cultures of Aeromonas hydrophila.

1993 • 42 citations

Expression of tissue transglutaminase in the developing chicken limb is associated both with apoptosis and endochondral ossification

1999 • 42 citations

Heat‐shock response in cultured chick embryo chondrocytes

1992 • 42 citations

Transglutaminase from Rat Coagulating Gland Secretion

1996 • 41 citations

Colocalization of Tissue Transglutaminase and Stress Fibers in Human Vascular Smooth Muscle Cells and Human Umbilical Vein Endothelial Cells

1997 • 41 citations

DIFFERENTIAL GROWTH OF N- AND S-TYPE HUMAN NEUROBLASTOMA CELLS XENOGRAFTED INTO SCID MICE. CORRELATION WITH APOPTOSIS

1996 • 41 citations

Role of histidine 373 in the catalytic activity of coagulation factor XIII.

1994 • 40 citations

Prolactin-immunoglobulin G complexes from human serum act as costimulatory ligands causing proliferation of malignant B lymphocytes.

1995 • 40 citations

Induction of Apoptosis Without Differentiation by Retinoic Acid in PLB-985 Cells Requires the Activation of Both RAR and RXR

1997 • 38 citations

The transglutaminase in vascular cells and tissues could provide an alternate pathway for fibrin stabilization

1987 • 37 citations

Expression and activation of tissue transglutaminase in apoptotic cells of involuting rodent mammary tissue.

1996 • 36 citations

Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase.

1994 • 36 citations

An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis.

1992 • 35 citations

Transglutaminase Forms Midkine Homodimers in Cerebellar Neurons and Modulates the Neurite-Outgrowth Response

1996 • 34 citations

Type II transglutaminase expression in rabbit articular chondrocytes in culture: relation with cell differentiation, cell growth, cell adhesion and cell apoptosis

1996 • 34 citations

Formation of high molecular weight dermatan sulfate proteoglycan in bovine aortic endothelial cell cultures. Evidence for transglutaminase-catalyzed cross-linking to fibronectin.

1990 • 34 citations

Association of a transglutaminase-related antigen with intermediate filaments.

1995 • 33 citations

Increase in ϵ(γ-glutamyl)lysine crosslinks in atherosclerotic aortas

1994 • 30 citations

Evidence for the Involvement of Both Retinoic Acid Receptor- and Retinoic X Receptor-Dependent Signaling Pathways in the Induction of Tissue Transglutaminase and Apoptosis in the Human Myeloma Cell Line RPMI 8226

1998 • 30 citations

A novel, specific pro‐urokinase complex on monocyte‐like cells, detected by transglutaminase‐catalyzed cross‐linking

1993 • 29 citations

Transglutaminases catalyze cross-linking of plasminogen to fibronectin and human endothelial cells.

1993 • 29 citations

Structure of a Covalently Cross-Linked Form of Core Histones Present in the Starfish Sperm

1997 • 26 citations

Factor XIII in Ulcerative Leg Disease: Background and Preliminary Clinical Results

1996 • 26 citations

Evidence that retinoic acid-induced apoptosis in the mouse limb bud core mesenchymal cells is gene-mediated.

1993 • 24 citations

Thanatogen Expression During Involution of the Rat Ventral Prostate After Castration

1994 • 24 citations

Fibronectin is a component of the sodium dodecyl sulfate-insoluble transglutaminase substrate.

1988 • 23 citations

Determination of amino- and carboxyl-terminal sequences of guinea pig liver transglutaminase: evidence for amino-terminal processing

1989 • 23 citations

The Normal and Abnormal Genes of theaandbSubunits in Coagulation Factor XIII

1996 • 22 citations

Gene Defects in Congenital Factor XIII Deficiency

1996 • 21 citations

A peroxidative model of human erythrocyte intracellular Ca2+ changes with in vivo cell aging: Measurement by 19F-NMR spectroscopy

1995 • 20 citations

Lipids associated with tissue transglutaminase

1987 • 20 citations

Involvement of transglutaminase in myofibril assembly of chick embryonic myoblasts in culture.

1995 • 20 citations

Effects of Inhibiting Transglutaminase During Egg Fertilization and Development

1994 • 19 citations

Increase Caused by Interleukin-6 in Promoter Activity of Guinea Pig Liver Transglutaminase Gene

1994 • 19 citations

The Molecular Biology of Skin

1976 • 18 citations

The Gene Encoding Protein 4.2 Is Distinct from the Mouse Platelet Storage Pool Deficiency Mutation Pallid

1997 • 18 citations

Therapeutic Factor XIII Preparations and Perspectives for Recombinant Factor XIII

1996 • 16 citations

Identification of promoter region of guinea pig liver transglutaminase gene

1993 • 13 citations

Solubilization and properties of the liver plasma membrane transglutaminase

1987 • 13 citations

Location of the Major ∊-(γ-Glutamyl)lysyl Cross-linking Site in Transglutaminase-modified Human Plasminogen

1995 • 11 citations

Expression of tissue transglutaminase in human bladder carcinoma

1997 • 11 citations

Expression of Transglutaminase C during the Prenatal Development of Human Submandibular Glands

1995 • 10 citations

Tissue transglutaminase in mesenchymal tumour cells

1996 • 4 citations