Hidden Markov Models in Computational Biology

A tutorial on hidden Markov models and selected applications in speech recognition

1989 • 22,242 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Construction of multilocus genetic linkage maps in humans.

1987 • 1,461 citations

[2] Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members

1991 • 1,225 citations

Prosite: a dictionary of sites and patterns in proteins

1992 • 952 citations

The classification of amino acid conservation

1986 • 559 citations

Determinants of a protein fold

1987 • 498 citations

[9] Profile analysis

1990 • 486 citations

Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences

1990 • 401 citations

The EF-hand family of calcium-modulated proteins

1989 • 353 citations

Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands

1992 • 346 citations

A hidden Markov model that finds genes inE.coliDNA

1994 • 329 citations

[1] Protein kinase classification

1991 • 317 citations

Reconstruction and analysis of human alu genes

1991 • 288 citations

Structural analysis based on state‐space modeling

1993 • 191 citations

[25] Protein multiple sequence alignment and flexible pattern matching

1990 • 191 citations

Using Dirichlet mixture priors to derive hidden Markov models for protein families.

1993 • 170 citations

Secondary structure‐based profiles: Use of structure‐conserving scoring tables in searching protein sequence databases for structural similarities

1991 • 170 citations

Evolution of EF-hand calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories

1992 • 165 citations

On the computational complexity of approximating distributions by probabilistic automata

1990 • 153 citations

Protein classification by stochastic modeling and optimal filtering of amino-acid sequences

1994 • 151 citations

Maximum Likelihood Competitive Learning

1989 • 138 citations

Flexible protein sequence patterns

1990 • 120 citations

Motif recognition and alignment for many sequences by comparison of dot-matrices

1991 • 116 citations

Protein modeling using hidden Markov models: analysis of globins

2002 • 95 citations

Weighting aligned protein or nucleic acid sequences to correct for unequal representation

1990 • 95 citations

A method for multiple sequence alignment with gaps

1989 • 80 citations

Line geometries for sequence comparisons

1984 • 70 citations

Finite-state models in the alignment of macromolecules

1992 • 69 citations

HMM with protein structure grammar

2002 • 27 citations

Hidden Markov Models in Molecular Biology: New Algorithms and Applications

1992 • 21 citations

Detection of correlations in tRNA sequences with structural implications.

1993 • 21 citations