The molecular genetics of myelination: An update

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Genes specifically expressed at growth arrest of mammalian cells

1988 • 954 citations

Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin

1985 • 538 citations

Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)

1951 • 517 citations

The gene for the peripheral myelin protein PMP–22 is a candidate for Charcot–Marie–Tooth disease type 1A

1992 • 497 citations

Mouse P0 gene disruption leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons

1992 • 493 citations

Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene

1987 • 479 citations

PROTEIN COMPOSITION OF MYELIN OF THE PERIPHERAL NERVOUS SYSTEM

1973 • 446 citations

Trembler mouse carries a point mutation in a myelin gene

1992 • 418 citations

Peripheral Neuropathy.

1984 • 417 citations

Characterization of a novel peripheral nervous system myelin protein (PMP-22/SR13)

1992 • 398 citations

The peripheral myelin protein gene PMP–22 is contained within the Charcot–Marie–Tooth disease type 1A duplication

1992 • 383 citations

Role of myelin Po protein as a homophilic adhesion molecule

1990 • 344 citations

Two forms of 1B236/myelin-associated glycoprotein, a cell adhesion molecule for postnatal neural development, are produced by alternative splicing.

1987 • 320 citations

The peripheral myelin gene PMP–22/GAS–3 is duplicated in Charcot–Marie–Tooth disease type 1A

1992 • 317 citations

Peripheral myelin protein–22 gene maps in the duplication in chromosome 17p11.2 associated with Charcot–Marie–Tooth 1A

1992 • 295 citations

A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse.

1992 • 286 citations

Proteins of Myelin

1977 • 281 citations

Protein zero of peripheral nerve myelin: Biosynthesis, membrane insertion, and evidence for homotypic interaction

1990 • 276 citations

A growth arrest-specific (gas) gene codes for a membrane protein.

1990 • 252 citations

Unwrapping the genes of myelin

1988 • 246 citations

Expression and Activity of the POU Transcription Factor SCIP

1990 • 244 citations

Abnormal myelination in transplanted Trembler mouse Schwann cells

1977 • 231 citations

Cellular and molecular aspects of myelin protein gene expression

1988 • 224 citations

A myelin protein is encoded by the homologue of a growth arrest-specific gene.

1991 • 217 citations

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene

1992 • 212 citations

Mutation of the proteolipid protein gene PLP in a human X chromosome-linked myelin disorder.

1989 • 205 citations

Proteins of Myelin

1984 • 183 citations

Conversion of Normal Behavior to Shiverer by Myelin Basic Protein Antisense cDNA in Transgenic Mice

1988 • 182 citations

Axon-regulated expression of a Schwann cell transcript that is homologous to a ‘growth arrest-specific’ gene.

1991 • 182 citations

A Single Nucleotide Difference in the Gene for Myelin Proteolipid Protein Defines the Jimpy Mutation in Mouse

1987 • 167 citations

Purification and partial characterization of two glycoproteins in bovine peripheral nerve myelin membrane

1976 • 157 citations

Selective Expression of DM‐20, an Alternatively Spliced Myelin Proteolipid Protein Gene Product, in Developing Nervous System and in Nonglial Cells

1992 • 141 citations

Complete amino acid sequence of PO protein in bovine peripheral nerve myelin.

1987 • 122 citations

P0 promoter directs expression of reporter and toxin genes to schwann cells of transgenic mice

1992 • 110 citations

Comparison of Trembler and Trembler-J Mouse Phenotypes

1983 • 99 citations

Schwann cells infected with a recombinant retrovirus expressing myelin-associated glycoprotein antisense RNA do not form myelin

1991 • 98 citations

Rumpshaker mouse: A new X-linked mutation affecting myelination: Evidence for a defect in PLP expression

1990 • 96 citations

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.

1990 • 96 citations

Dissecting mouse development with toxigenics.

1989 • 89 citations

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice

1990 • 85 citations

The role of complex carbohydrates in adhesion of the myelin protein, P0

1991 • 83 citations

Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2

1991 • 69 citations

Long Lives for Homozygous Trembler Mutant Mice Despite Virtual Absence of Peripheral Nerve Myelin

1988 • 62 citations

Rumpshaker: An X‐linked mutation causing hypomyelination: Developmental differences in myelination and glial cells between the optic nerve and spinal cord

1992 • 51 citations

Expressing antisense Po RNA in Schwann cells perturbs myelination

1991 • 49 citations

Proteolipid proteins: structure and genetic expression in normal and myelin-deficient mutant mice.

1989 • 47 citations

Dissection of the Phenotype and Genotype of the X‐Linked Myelin Mutants^a

1990 • 40 citations

An Introduction to Molecular Neurobiology

1992 • 39 citations

A novel mutation in myelin-deficient mice results in unstable myelin basic protein gene transcripts

1988 • 37 citations

Status of the linkage map of the mouse

1978 • 34 citations

Localization of growth arrest-specific genes on mouse Chromosomes 1, 7, 8, 11, 13, and 16

1992 • 33 citations

Molecular Genetics of X‐Linked Mutants

1990 • 26 citations

The Murine Mutation Trembler-J: Proof of Semidominant Expression by Use of the Linked Vestigial Tail Marker

1983 • 23 citations