RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects

1995 • 921 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

Calcium dependence of the rate of exocytosis in a synaptic terminal

1994 • 746 citations

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

1993 • 716 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

1997 • 673 citations

Nonuniform Probability of Glutamate Release at a Hippocampal Synapse

1993 • 641 citations

The probability of transmitter release at a mammalian central synapse

1993 • 632 citations

Membrane Fusion

1992 • 613 citations

Specificity and regulation of a synaptic vesicle docking complex

1994 • 601 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

1996 • 580 citations

Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin

1993 • 551 citations

Two components of transmitter release at a central synapse.

1994 • 528 citations

Complexins: Cytosolic proteins that regulate SNAP receptor function

1995 • 494 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion

1994 • 485 citations

The role of Rab3A in neurotransmitter release

1994 • 481 citations

Mutational analysis of Drosophila synaptotagmin demonstrates its essential role in Ca2+-activated neurotransmitter release

1993 • 457 citations

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

1995 • 455 citations

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

1991 • 441 citations

Synaptotagmins: C2-Domain Proteins That Regulate Membrane Traffic

1996 • 439 citations

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

1997 • 414 citations

Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins

1995 • 404 citations

n-Sec1: a neural-specific syntaxin-bindingprotein.

1994 • 392 citations

Syntaxin and synaptobrevin function downstream of vesicle docking in drosophila

1995 • 389 citations

Synaptic Vesicles and Exocytosis

1994 • 371 citations

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

1997 • 360 citations

Domain structure of synaptotagmin (p65)

1991 • 350 citations

PDZs and Receptor/Channel Clustering: Rounding Up the Latest Suspects

1996 • 322 citations

Genetic and electrophysiological studies of drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission

1995 • 321 citations

Bipartite Ca ²⁺ -Binding Motif in C ₂ Domains of Synaptotagmin and Protein Kinase C

1996 • 307 citations

Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin

1997 • 306 citations

Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis

1993 • 282 citations

Rab proteins and the road maps for intracellular transport

1993 • 276 citations

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

1990 • 268 citations

A post-docking role for synaptobrevin in synaptic vesicle fusion

1994 • 255 citations

Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release.

1996 • 255 citations

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.

1993 • 253 citations

Synaptic transmission persists in synaptotagmin mutants of Drosophila

1993 • 249 citations

A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin.

1994 • 247 citations

Synaptotagmin–Syntaxin Interaction: The C2 Domain as a Ca2+-Dependent Electrostatic Switch

1997 • 244 citations

Mutations in the drosophila Rop gene suggest a function in general secretion and synaptic transmission

1994 • 241 citations

Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle.

1994 • 240 citations

A role for synaptotagmin (p65) in regulated exocytosis

1993 • 233 citations

GPI-anchored influenza hemagglutinin induces hemifusion to both red blood cell and planar bilayer membranes.

1995 • 227 citations

Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.

1994 • 209 citations

Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission.

1994 • 206 citations

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

1994 • 197 citations

Functional properties of multiple synaptotagmins in brain

1994 • 195 citations

Isolation and Characterization of a GTPase Activating Protein Specific for the Rab3 Subfamily of Small G Proteins

1997 • 183 citations

Isolation and Characterization of a GDP/GTP Exchange Protein Specific for the Rab3 Subfamily Small G Proteins

1997 • 174 citations

C terminus of the small GTP-binding protein smg p25A contains two geranylgeranylated cysteine residues and a methyl ester.

1991 • 169 citations

The Evolutionary Pressure to Inactivate

1997 • 166 citations

Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis

1994 • 151 citations

Overexpression of ∊-Protein Kinase C Enhances Nerve Growth Factor-induced Phosphorylation of Mitogen-activated Protein Kinases and Neurite Outgrowth

1995 • 143 citations

Tetanus and Botulinum Neurotoxins Are Zinc Proteases Specific for Components of the Neuroexocytosis Apparatus^a

1994 • 143 citations

Distinct Ca2+ and Sr2+ Binding Properties of Synaptotagmins

1995 • 141 citations

Distinct Ca2+-dependent Properties of the First and Second C2-domains of Synaptotagmin I

1996 • 137 citations

Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras.

1996 • 136 citations

Two functionally different domains of rabphilin-3A, Rab3A p25/smg p25A-binding and phospholipid- and Ca(2+)-binding domains.

1993 • 132 citations

Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro

1995 • 118 citations

rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence

1991 • 99 citations

Interaction Cloning of Rabin3, a Novel Protein That Associates with the Ras-Like GTPase Rab3A

1995 • 79 citations

Molecular cloning and characterization of two rab GDI species from rat brain: brain-specific and ubiquitous types.

1994 • 79 citations

Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.

1994 • 76 citations

Rabphilin-3A is associated with synaptic vesicles through a vesicle protein in a manner independent of Rab3A

1994 • 64 citations

Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae

1993 • 43 citations

Neuromuscular junctions in the nematode C. elegans

1995 • 39 citations