Single and Combined Prothrombotic Factors in Patients With Idiopathic Venous Thromboembolism

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

1996 • 3,124 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

World distribution of factor V Leiden

1995 • 1,184 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis

1995 • 1,117 citations

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

1994 • 1,065 citations

Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy Men

1995 • 1,060 citations

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

1995 • 1,036 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Geographic Distribution of the 20210 G to A Prothrombin Variant

1998 • 707 citations

Inherited Thrombophilia: Part 1

1996 • 600 citations

Deficiencies of Coagulation-Inhibiting and Fibrinolytic Proteins in Outpatients with Deep-Vein Thrombosis

1990 • 456 citations

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families

1994 • 446 citations

Familial Dysfibrinogenemia and Thrombophilia

1995 • 326 citations

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S

1995 • 314 citations

The Mutation Ala677→Val in the Methylene Tetrahydrofolate Reductase Gene: A Risk Factor for Arterial Disease and Venous Thrombosis

1997 • 313 citations

Coexistence of Hereditary Homocystinuria and Factor V Leiden — Effect on Thrombosis

1996 • 266 citations

The 20210 A Allele of the Prothrombin Gene Is a Common Risk Factor among Swedish Outpatients with Verified Deep Venous Thrombosis

1997 • 255 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Factor V Leiden (FV R506Q) in Families with Inherited Antithrombin Deficiency

1996 • 237 citations

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

1997 • 236 citations

The Incidence of Venous Thromboembolism in Family Members of Patients with Factor V Leiden Mutation and Venous Thrombosis

1998 • 207 citations

Thrombophilia as a Multigenic Disorder

1997 • 204 citations

Detection and Quantitative Evaluation of Lupus Circulating Anticoagulant Activity

1987 • 183 citations

Co-inheritance of the 20210A Allele of the Prothrombin Gene Increases the Risk of Thrombosis in Subjects with Familial Thrombophilia

1997 • 177 citations

Prevalence of the Prothrombin Gene Variant (nt20210A) in Venous Thrombosis and Arterial Disease

1997 • 175 citations

The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic population

1997 • 172 citations

A Common Mutation in the Methylenetetrahydrofolate Reductase Gene (C677T) Increases the Risk for Deep-Vein Thrombosis in Patients With Mutant Factor V (Factor V:Q ⁵⁰⁶ )

1997 • 171 citations

The Heterozygous 20210 G/A Prothrombin Genotype Is Associated With Early Venous Thrombosis in Inherited Thrombophilias and Is Not Increased in Frequency in Artery Disease

1997 • 170 citations

Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3′‐untranslated region of the prothrombin gene

1997 • 160 citations

Thermolabile Methylenetetrahydrofolate Reductase and Factor V Leiden in the Risk of Deep-Vein Thrombosis

1998 • 160 citations

Factor V Leiden: An Additional Risk Factor for Thrombosis in Protein S Deficient Families?

1995 • 152 citations

A Single Genetic Origin for the Common Prothrombotic G20210A Polymorphism in the Prothrombin Gene

1998 • 147 citations

Hyperhomocysteinemia and Deep-Vein Thrombosis A Case-Control Study

1996 • 131 citations

Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C Due to an Arg-to-Gln Mutation in the Gene for Factor V

1994 • 125 citations

The Relative Frequency of Hereditary Thrombotic Disorders Among 107 Patients with Thrombophilia in Israel

1989 • 106 citations

Familial thrombophilia: a complex genetic disorder.

1997 • 101 citations

The first mutation identified in the thrombomodulin gene in a 45-year- old man presenting with thromboembolic disease

1995 • 95 citations

A Prothrombin Gene Mutation Is Significantly Associated With Venous Thrombosis

1997 • 83 citations

The VITA Project: C677T mutation in the methylene‐tetrahydrofolate reductase gene and risk of venous thromboembolism

1997 • 81 citations

Venous thromboembolism associated with double heterozygosity for R506Q mutation of factor V and for T298M mutation of protein C in a large family of a previously described homozygous protein C-deficient newborn with massive thrombosis

1996 • 67 citations

The factor VR506Q mutation causing APC resistance is highly prevalent amongst unselected outpatients with clinically suspected deep venous thrombosis

1997 • 57 citations

The Prothrombin Gene 3′-Untranslated Region Mutation Is Frequently Associated With Factor V Leiden in Thrombophilic Patients and Shows Ethnic-Specific Variation in Allele Frequency

1998 • 38 citations

The G1691A mutation of the coagulation factor V gene (factor V Leiden) is rare in Chinese: an analysis of 618 individuals

1996 • 33 citations

Low prevalence of activated protein C resistance and coagulation factor V Arg506 to Gln mutation among Japanese patients with various forms of thrombosis, and normal individuals.

1996 • 32 citations

The Prothrombin Gene 3′-Untranslated Region Mutation Is Frequently Associated With Factor V Leiden in Thrombophilic Patients and Shows Ethnic-Specific Variation in Allele Frequency

1998 • 27 citations

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