Thermolabile Methylenetetrahydrofolate Reductase and Factor V Leiden in the Risk of Deep-Vein Thrombosis

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

1996 • 1,423 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

1985 • 1,251 citations

World distribution of factor V Leiden

1995 • 1,184 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1995 • 870 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.

1995 • 421 citations

Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells

1990 • 392 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells.

1993 • 314 citations

Coexistence of Hereditary Homocystinuria and Factor V Leiden — Effect on Thrombosis

1996 • 266 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Thermolabile Methylenetetrahydrofolate Reductase in Coronary Artery Disease

1997 • 230 citations

Decreased methylene tetrahydrofolate reductase activity due to the 677C→T mutation in families with spina bifida offspring

1996 • 154 citations

Three Different Methods for the Determination of Total Homocysteine in Plasma

1995 • 143 citations

Plasma Homocysteine in Venous Thromboembolism

1991 • 98 citations

Plasma Homocysteine Levels in Patients With Deep Venous Thrombosis

1995 • 70 citations

No evidence for an increased risk of venous thrombosis in patients with factor V Leiden by the homozygous 677 C to T mutation in the methylenetetrahydrofolate-reductase gene

1999 • 33 citations

Will a decrease of blood homocysteine by vitamin supplementation reduce the risk for vascular disease?

1994 • 9 citations