Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Regression Models and Life-Tables

1992 • 27,454 citations

Regression Models and Life-Tables

1972 • 27,145 citations

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

Familial protein S deficiency is associated with recurrent thrombosis.

1984 • 614 citations

Absence of Thrombosis in Subjects with Heterozygous Protein C Deficiency

1987 • 529 citations

Plasma protein S deficiency in familial thrombotic disease

1984 • 516 citations

Recurrent Venous Thromboembolism in Patients with a Partial Deficiency of Protein S

1984 • 507 citations

Deficiencies of Coagulation-Inhibiting and Fibrinolytic Proteins in Outpatients with Deep-Vein Thrombosis

1990 • 456 citations

Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V

1994 • 446 citations

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families

1994 • 446 citations

Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C.

1994 • 430 citations

Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis

1994 • 428 citations

Hereditary Protein S Deficiency: Clinical Manifestations

1987 • 391 citations

High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein.

1981 • 373 citations

Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect

1993 • 354 citations

Inhibition of protein Ca cofactor function of human and bovine protein S by C4b-binding protein.

1986 • 296 citations

An abnormal plasma distribution of protein S occurs in functional protein S deficiency

1986 • 289 citations

The Frequency of Type I Heterozygous Protein S and Protein C Deficiency in 141 Unrelated Young Patients with Venous Thrombosis

1988 • 227 citations

Hereditary Protein C Deficiency

1985 • 189 citations

Evaluation of the relationship between protein S and C4b-binding protein isoforms in hereditary protein S deficiency demonstrating type I and type III deficiencies to be phenotypic variants of the same genetic disease

1995 • 168 citations

Novel subunit in C4b-binding protein required for protein S binding.

1988 • 151 citations

Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia

1994 • 129 citations

Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis

1991 • 127 citations

Thromboembolic Disease – Critical Evaluation of Laboratory Investigation

1992 • 119 citations

Hereditary protein S deficiency and venous thrombo-embolism. A study in three Dutch families.

1985 • 108 citations

The Relative Frequency of Hereditary Thrombotic Disorders Among 107 Patients with Thrombophilia in Israel

1989 • 106 citations

Protein S binding in relation to the subunit composition of human C4b‐binding protein

1989 • 95 citations

Hereditary Protein S Deficiency in Young Adults with Arterial Occlusive Disease

1990 • 90 citations

Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis

1991 • 87 citations

Protein C Deficiency in Two Austrian Families

1983 • 83 citations

Inherited deficiency of protein S in a Japanese family with recurrent venous thrombosis: a study of three generations

1986 • 71 citations

Recurrent venous thromboembolism in patients with a partial deficiency of protein S

1985 • 67 citations

The protein C anticoagulant system

1996 • 52 citations

Familial Dysfunction of Protein S

1989 • 46 citations

Hereditary Protein S Deficiency

1985 • 45 citations

Homozygous APC-resistance Combined with Inherited Type I Protein S Deficiency in a Young Boy with Severe Thrombotic Disease

1995 • 44 citations

Plasma protein S deficiency in familial thrombotic disease

1984 • 44 citations

A Protein S Deficient Family with Portal Vein Thrombosis

1985 • 40 citations

An abnormal plasma distribution of protein S occurs in functional protein S deficiency

1986 • 22 citations

The natural anticoagulant protein S is decreased in male smokers

1991 • 17 citations

Incidence and clinical characteristics of hereditary disorders associated with venous thrombosis

1992 • 13 citations

Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia

1994 • 9 citations

Inherited deficiency of protein S in a Japanese family with recurrent venous thrombosis: a study of three generations

1986 • 8 citations

Protein S activity in patients with heredofamilial protein S deficiency and in patients with juvenile venous thrombosis. Results of a functional method

1991 • 6 citations

Protein S deficiency in 7 Austrian families

1986 • 5 citations