The Mutation Ala677→Val in the Methylene Tetrahydrofolate Reductase Gene: A Risk Factor for Arterial Disease and Venous Thrombosis

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease

1995 • 3,645 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

Hyperhomocysteinemia as a Risk Factor for Deep-Vein Thrombosis

1996 • 1,034 citations

Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial Disease

1985 • 739 citations

Hyperhomocyst(e)inemia as a Risk Factor for Occlusive Vascular Disease

1992 • 726 citations

Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.

1996 • 670 citations

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.

1991 • 615 citations

Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy.

1989 • 615 citations

Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase.

1988 • 607 citations

Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.

1988 • 479 citations

Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia

1993 • 475 citations

Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.

1995 • 421 citations

A prospective study of plasma homocyst(e)ine and risk of ischemic stroke.

1994 • 386 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Antithrombin (heparin cofactor) assay with “new” chromogenic substrates (S-2238 and Chromozym TH)

1977 • 369 citations

Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.

1995 • 263 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Treatment of mild hyperhomocysteinemia in vascular disease patients.

1994 • 186 citations

Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease

1988 • 175 citations

Distribution in Healthy and Coronary Populations of the Methylenetetrahydrofolate Reductase (MTHFR) C ₆₇₇ T Mutation

1996 • 173 citations

Molecular basis of phenotype expression in homocystinuria

1994 • 107 citations

A study of cardiovascular risk in heterozygotes for homocystinuria.

1981 • 95 citations

Effective homocysteine metabolism may protect South African blacks against coronary heart disease

1995 • 91 citations

Hyperhomocysteinaemia: a metabolic risk factor for coronary heart disease determined by both genetic and environmental influences?

1993 • 44 citations

Hyperhomocysteinemia as a risk factor for stroke

1992 • 31 citations

Four‐agent induction/consolidation therapy for childhood acute lymphoblastic leukemia: An Indian experience

1992 • 25 citations

Protein C: A simplified semi-automated activity assay

1986 • 11 citations