Coexistence of Hereditary Homocystinuria and Factor V Leiden — Effect on Thrombosis

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease

1991 • 2,191 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

The natural history of homocystinuria due to cystathionine beta-synthase deficiency.

1985 • 1,251 citations

Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis

1995 • 1,244 citations

Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation

1994 • 1,065 citations

Disorders of transsulfuration

1989 • 1,053 citations

High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]

1995 • 1,036 citations

Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum

1991 • 702 citations

The Regulation of Natural Anticoagulant Pathways

1987 • 702 citations

Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine.

1991 • 451 citations

Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient families

1994 • 446 citations

Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells

1990 • 392 citations

Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator.

1986 • 390 citations

Vitamin status and intake as primary determinants of homocysteinemia in an elderly population

1993 • 386 citations

Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis?

1995 • 374 citations

Resistance to activated protein C as an additional genetic risk factor in hereditary deficiency of protein S

1995 • 314 citations

Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism

1995 • 307 citations

Techniques in diagnostic human biochemical genetics : a laboratory manual

1991 • 264 citations

High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis.

1994 • 251 citations

Homocysteinemia: Association of a metabolic disorder with vascular disease and thrombosis

1993 • 249 citations

Microvillus Inclusion Disease: An Inherited Defect of Brush-Border Assembly and Differentiation

1989 • 211 citations

Inherited disorders of folate transport and metabolism

1995 • 201 citations

Antiphospholipid Antibodies and Recurrent Pregnancy Loss

1989 • 163 citations

Factor V Leiden: An Additional Risk Factor for Thrombosis in Protein S Deficient Families?

1995 • 152 citations

Cystathionine Synthase in Tissue Culture Derived from Human Skin: Enzyme Defect in Homocystinuria

1968 • 146 citations

Variability of Thrombosis among Homozygous Siblings with Resistance to Activated Protein C Due to an Arg-to-Gln Mutation in the Gene for Factor V

1994 • 125 citations

Incidence of activated protein C resistance caused by the ARG 506 GLN mutation in factor V in 113 unrelated symptomatic protein C-deficient patients. The French Network on the behalf of INSERM

1995 • 119 citations

Folate Distribution in Cultured Human Cells

1979 • 61 citations

Betaine for treatment of homocystinuria caused by methylenetetrahydrofolate reductase deficiency.

1989 • 61 citations

Familial Selective Vitamin B₁₂Malabsorption

1972 • 53 citations

Methylenetetrahydrofolate Reductase in Cultured Human Cells. II. Genetic and Biochemical Studies of Methylenetetrahydrofolate Reductase Deficiency

1977 • 51 citations

Management of Patients with Hereditary Defects Predisposing to Thrombosis Including Pregnant Women

1995 • 49 citations

Vitamin B₁₂ responsive homocystinuria and megaloblastic anemia: Heterogeneity in methylcobalamin deficiency

1987 • 31 citations

Cobalamin inactivation decreases purine and methionine synthesis in cultured lymphoblasts.

1985 • 23 citations