The first mutation identified in the thrombomodulin gene in a 45-year- old man presenting with thromboembolic disease

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 411 citations

Structure and function of thrombomodulin: a natural anticoagulant

1990 • 385 citations

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

1987 • 358 citations

Plasma thrombomodulin in health and diseases

1990 • 357 citations

Soluble Thrombomodulin Antigen in Conditioned Medium Is Increased by Damage of Endothelial Cells

1991 • 345 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

The Frequency of Type I Heterozygous Protein S and Protein C Deficiency in 141 Unrelated Young Patients with Venous Thrombosis

1988 • 227 citations

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene

1987 • 209 citations

Inherited predisposition to thrombosis

1993 • 166 citations

Hereditary deficiency of antithrombin III, protein C and protein S: prevalence in patients with a history of venous thrombosis and criteria for rational patient screening.

1992 • 151 citations

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.

1988 • 130 citations

Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control.

1987 • 126 citations

Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor.

1986 • 125 citations

Thromboembolic Disease – Critical Evaluation of Laboratory Investigation

1992 • 119 citations

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells.

1990 • 117 citations

Circulating thrombomodulin as a novel endothelial cell marker: Comparison of its behavior with von willebrand factor and tissue‐type plasminogen activator

1992 • 108 citations

Levels of plasma thrombomodulin are increased in atheromatous arterial disease

1993 • 108 citations

The Relative Frequency of Hereditary Thrombotic Disorders Among 107 Patients with Thrombophilia in Israel

1989 • 106 citations

Further localization of binding sites for thrombin and protein C in human thrombomodulin

1990 • 80 citations

Presence and function of chondroitin-4-sulfate on recombinant human soluble thrombomodulin

1990 • 66 citations

Structure-Function Relationships of the Thrombin-Thrombomodulin Interaction

1993 • 64 citations

A Frequent Thrombomodulin Amino Acid Dimorphism Is not Associated with Thrombophilia

1991 • 63 citations

THROMBOPHILIA:ITS CAUSES AND A ROUGH ESTIMATE OF ITS PREVALENCE

1987 • 59 citations

The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.

1993 • 57 citations

Gene Structure of Human Thrombomodulin, a Cofactor for Thrombin Catalyzed Activation of Protein C1

1988 • 52 citations

Sequence of a cDNA for mouse thrombomodulin and comparison of the predicted mouse and human amino acid sequences

1989 • 21 citations

Soluble thrombomodulin antigen in plasma is increased in patients with acute myocardial infarction treated with thrombolytic therapy

1996 • 19 citations

Changes in thrombomodulin level in plasma of endotoxin-infused rabbits

1992 • 16 citations