A Single Genetic Origin for the Common Prothrombotic G20210A Polymorphism in the Prothrombin Gene

Mutation in blood coagulation factor V associated with resistance to activated protein C

1994 • 3,871 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis

1996 • 3,124 citations

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study

1993 • 1,283 citations

World distribution of factor V Leiden

1995 • 1,184 citations

Resistance to Activated Protein C as a Basis for Venous Thrombosis

1994 • 1,148 citations

Geographic Distribution of the 20210 G to A Prothrombin Variant

1998 • 707 citations

Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V

1994 • 446 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 411 citations

Anticoagulant protein C pathway defective in majority of thrombophilic patients [see comments]

1993 • 337 citations

Nucleotide sequence of the gene for human prothrombin

1987 • 258 citations

The 20210 A Allele of the Prothrombin Gene Is a Common Risk Factor among Swedish Outpatients with Verified Deep Venous Thrombosis

1997 • 255 citations

A Single Genetic Origin for a Common Caucasian Risk Factor for Venous Thrombosis

1997 • 236 citations

Thrombophilia as a Multigenic Disorder

1997 • 204 citations

The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic population

1997 • 172 citations

Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3′‐untranslated region of the prothrombin gene

1997 • 160 citations

Human genes encoding prothrombin and ceruloplasmin map to 11p11?q12 and 3q21?24, respectively

1987 • 100 citations

Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia

1996 • 39 citations

Characterization of the Alu-rich 5′-flanking region of the human prothrombin-encoding gene: identification of a positive cis-acting element that regulates liver-specific expression

1990 • 19 citations

A point mutation (Arg271→Cys) of a homozygote for dysfunctional prothrombin, prothrombin Obihiro, which has a region of high sequence variability

1995 • 15 citations

Highly polymorphic region of the human prothrombin (F2) gene

1992 • 9 citations