Mitogenic factors accelerate later-age diseases: insulin as a paradigm

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

1991 • 4,548 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Hyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease

1996 • 1,727 citations

The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension

1989 • 1,560 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

1985 • 1,485 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

Pathophysiology of insulin resistance in human disease

1995 • 1,239 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?

1990 • 1,020 citations

Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome

1991 • 930 citations

The Deadly Quartet

1989 • 789 citations

Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations

1979 • 746 citations

Genetic determination of telomere size in humans: a twin study of three age groups.

1994 • 738 citations

Insulin Sensitivity and Atherosclerosis

1996 • 726 citations

PATHOGENESIS OF TYPE 2 DIABETES: METABOLIC AND MOLECULAR IMPLICATIONS FOR IDENTIFYING DIABETES GENES

1997 • 701 citations

Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study

1997 • 683 citations

A Prospective Study of Maturity-Onset Diabetes Mellitus and Risk of Coronary Heart Disease and Stroke in Women

1991 • 664 citations

Association of diabetes mellitus and dementia: The Rotterdam Study

1996 • 650 citations

Telomere length and replicative aging in human vascular tissues.

1995 • 630 citations

Cardiovascular Risk Factors in Confirmed Prediabetic Individuals

1990 • 608 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

The relationship between in vitro cellular aging and in vivo human age.

1976 • 559 citations

Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

1996 • 549 citations

The biology of replicative senescence

1997 • 511 citations

Memory improvement following induced hyperinsulinemia in alzheimer's disease

1996 • 495 citations

Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study

1997 • 427 citations

George Lyman Duff Memorial Lecture. Atherogenesis in diabetes.

1992 • 411 citations

Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up

1991 • 395 citations

Plasma Insulin as Coronary Heart Disease Risk Factor: Relationship to other Risk Factors and Predictive Value during 9½‐year Follow‐up of the Helsinki Policemen Study Population

1985 • 365 citations

Obesity as a disease

1997 • 362 citations

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

1986 • 346 citations

Accelerated telomere shortening in ataxia telangiectasia

1996 • 334 citations

Telomeres and telomerase in aging and cancer

1995 • 328 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Effects of Weight Loss vs Aerobic Exercise Training on Risk Factors for Coronary Disease in Healthy, Obese, Middle-aged and Older Men

1995 • 305 citations

Dietary Restriction Alters Characteristics of Glucose Fuel Use

1992 • 304 citations

Insulin Resistance or Insulin Deficiency: Which Is the Primary Cause of NIDDM?

1994 • 297 citations

Vascular dysfunction in diabetes mellitus

1997 • 285 citations

Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus.

1988 • 280 citations

The epidemiology of cardiovascular disease in type 2 diabetes mellitus: how sweet it is … or is it?

1997 • 269 citations

Risk Factors for NIDDM in White Population: Paris Prospective Study

1991 • 238 citations

Dietary restriction increases insulin sensitivity and lowers blood glucose in rhesus monkeys

1994 • 235 citations

Cell aging in vivo and in vitro

1997 • 232 citations

Insulin Resistance Implications for Type II Diabetes Mellitus and Coronary Heart Disease

1997 • 230 citations

Plasma Insulin Response Among Nauruans: Prediction of Deterioration in Glucose Tolerance Over 6 Yr

1987 • 229 citations

Cataloging altered gene expression in young and senescent cells using enhanced differential display

1995 • 225 citations

Relationships between plasma insulin triglyceride, body mass index, and plasminogen activator inhibitor 1.

1987 • 219 citations

Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments?

1994 • 216 citations

Asymptomatic atherosclerosis and insulin resistance.

1991 • 212 citations

Cardiovascular disease risk factors as predictors of Type 2 (non-insulin-dependent) diabetes mellitus in elderly subjects

1993 • 211 citations

Insulin resistance and coronary artery disease

1996 • 211 citations

Effects of low doses of transdermal 17 beta-estradiol on carbohydrate metabolism in postmenopausal women.

1992 • 202 citations

Hyperinsulinemia and Decreased Insulin-Like Growth Factor-Binding Protein-1 Are Common Features in Prepubertal and Pubertal Girls with a History of Premature Pubarche1

1997 • 196 citations

Low incidence of fatal coronary heart disease in Pima Indians despite high prevalence of non-insulin-dependent diabetes.

1990 • 190 citations

Chronologic and Physiologic Age Affect Replicative Life-Span of Fibroblasts from Diabetic, Prediabetic, and Normal Donors

1978 • 188 citations

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

1996 • 187 citations

Association of Elevated Fasting C-Peptide Level and Increased Intra-Abdominal Fat Distribution With Development of NIDDM in Japanese-American Men

1990 • 187 citations

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

1997 • 184 citations

Insulin resistance, compensatory hyperinsulinaemia, and coronary heart disease

1994 • 183 citations

Is Insulin Really a Heart Disease Risk Factor?

1995 • 167 citations

Glucose tolerance and insulin action in healthy centenarians

1996 • 152 citations

In situ analysis of changes in telomere size during replicative aging and cell transformation.

1996 • 152 citations

Aging, Metabolism, and Alzheimer Disease: Review and Hypotheses

1997 • 146 citations

Diverse signaling pathways in the cellular actions of insulin

1996 • 144 citations

Hyperinsulinaemia is not a major coronary risk factor in elderly men

1992 • 142 citations

Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points

1995 • 140 citations

Changes in Blood Glucose and Insulin Secretion in Patients with Senile Dementia of Alzheimer Type

1983 • 139 citations

Asymptomatic atherosclerosis and insulin resistance.

1991 • 138 citations

Non-parallel evolution of metabolic and growth-promoting functions of insulin

1981 • 129 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

Metabolic Control and Prevalent Cardiovascular Disease in Non-Insulin-dependent Diabetes Mellitus (NIDDM): The NIDDM Patient Outcomes Research Team

1997 • 125 citations

Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse

1990 • 123 citations

Do Non-Insulin-dependent Diabetes Mellitus and Cardiovascular Disease Share Common Antecedents?

1996 • 120 citations

Functional expression of insulin receptor substrate-1 is required for insulin-stimulated mitogenic signaling.

1993 • 116 citations

Retardation of the Aging Processes in Rats by Food Restriction

1991 • 115 citations

Demonstration, of Insulin Resistance in Coronary Artery Disease Documented With Angiography

1996 • 113 citations

High fasting plasma insulin is an indicator of coronary heart disease in non-insulin-dependent diabetic patients and nondiabetic subjects.

1991 • 112 citations

Senescence-Dependent Regulation of Type 1 Plasminogen Activator Inhibitor in Human Vascular Endothelial Cells

1995 • 110 citations

Insulin as a predictor of coronary heart disease: Interaction with apolipoprotein E phenotype A report from the multiple risk factor intervention trial

1994 • 99 citations

Hyperinsulinemia and Atherosclerosis

1996 • 97 citations

Abnormalities in Proliferation and Protein Synthesis in Skin Fibroblast Cultures from Patients with Diabetes Mellitus

1977 • 92 citations

Exogenous Insulin Administration and Cardiovascular Risk in Non-Insulin-dependent and Insulin-dependent Diabetes Mellitus

1996 • 90 citations

Why is insulin not a risk factor for coronary heart disease?

1994 • 83 citations

The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects.

1996 • 67 citations

The cardiovascular risk associated with impaired glucose tolerance.

1996 • 67 citations

Insulin Treatment, Endogenous Insulin Concentration, and ECG Abnormalities in Diabetic Pima Indians: Cross-Sectional and Prospective Analyses

1992 • 66 citations

Multiple metabolic abnormalities in normal glucose tolerant relatives of NIDDM families

1997 • 66 citations

Why can high insulin levels indicate a risk for coronary heart disease?

1994 • 62 citations

Caloric Restriction: Conservation of in Vivo Cellular Replicative Capacity Accompanies Life-Span Extension in Mice

1995 • 61 citations

Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-year follow-up and development of coronary heart disease in Edinburgh men

1992 • 59 citations

Role of the time factor in signaling specificity: Application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases

1995 • 58 citations

Daily insulin dose as a predictor of macrovascular disease in insulin treated non-insulin-dependent diabetics.

1987 • 58 citations

Immunological demonstration of the accumulation of insulin, but not insulin receptors, in nuclei of insulin-treated cells.

1989 • 58 citations

Obseity, non-insulin-dependent diabetes mellitus and the metabolic syndrome

1997 • 57 citations

Aging under glass

1991 • 54 citations

The Feasibility of Intensive Insulin Management in Non-Insulin-dependent Diabetes Mellitus: Implications of the Veterans Affairs Cooperative Study on Glycemic Control and Complications in NIDDM

1996 • 53 citations

Insulin Resistance and Abnormal Electrocardiograms in Patients With High Blood Pressure

1992 • 52 citations

Hyperinsulinemia—How Innocent a Bystander?

1993 • 52 citations

Overexpression of plasminogen activator inhibitor type‐1 in senescent fibroblasts from normal subjects and those with Werner syndrome

1994 • 50 citations

Reflections on Telomeres, Growth, Aging, and Essential Hypertension

1997 • 50 citations

Restricted replicative life-span of diabetic fibroblasts in vitro: its relation to microangiopathy

1975 • 44 citations

Insulin Resistance: a Multifaceted Metabolic Syndrome. Insights Gained Using a Low-dose Insulin Infusion Technique

1996 • 42 citations

Sex Differences in Insulin Levels in Older Adults and the Effect of Body Size, Estrogen Replacement Therapy, and Glucose Tolerance Status: The Rancho Bernardo Study, 1984–1987

1995 • 41 citations

Predictors of coronary heart disease and death in NIDDM: The Diabetes Intervention Study experience

1997 • 41 citations

In vivo DNA synthesis in the dietary restricted long-lived rat

1985 • 40 citations

Plasma insulin levels in Japanese and Japanese-American men with type 2 diabetes may be related to the occurrence of cardiovascular disease

1989 • 40 citations

Are Insulin and Proinsulin Independent Risk Markers for Premature Coronary Artery Disease?

1996 • 39 citations

Decrease by chronic energy intake restriction of cellular proliferation in the intestinal epithelium and lymphoid organs in autoimmunity-prone mice.

1989 • 38 citations

Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental regulation of insulin receptor gene splicing, and comparison to abundance of insulin-like growth factor 1 receptor mRNA.

1992 • 37 citations

Dissociation between urinary albumin excretion and variables associated with insulin resistance in a healthy population

1996 • 35 citations

Fasting hyperinsulinemia and cardiovascular disease risk factors in nondiabetic adults: Stronger associations in lean versus obese subjects*1

1995 • 35 citations

The Impact of Insulin Upon Atherosclerosis

1994 • 28 citations

Relationships of Insulin and Intact and Split Proinsulin to Haemostatic Function in Young Men with and without Coronary Artery Disease

1995 • 27 citations

Serum insulin and ECG abnormalities suggesting coronary heart disease in the populations of Mauritius and Nauru: Cross-sectional and longitudinal associations

1993 • 19 citations

Does Gene Expression Play Any Role in the Mechanism of the Antiaging Effect of Dietary Restriction?

1992 • 19 citations

Alteration of the counterregulatory hormones in the conscious rat after protein-energy restriction

1997 • 17 citations

Effect of human growth hormone and insulin on [3H]thymidine incorporation, cell cycle progression, and cyclin D expression in 3T3-F442A preadipose cells.

1995 • 16 citations

McCay's hypothesis: undernutrition and longevity

1995 • 16 citations

The role of insulin in age-related sex differences of cardiovascular risk profile and morbidity

1997 • 15 citations

Calories, Cell Proliferation, and Proviral Expression in Autoimmunity and Cancer

1993 • 14 citations

Perspectives in Diabetes Insulin Resistance or Insulin Deficiency Which Is the Primary Cause of NIDDM

1994 • 9 citations

Senescence: In search of causality

1996 • 7 citations

Insulin sensitivity in cardiological syndrome X

1996 • 3 citations

Deleted Work

1955 • 0 citations