Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Growth Factors and Cancer

1991 • 2,044 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

The insulin signaling system.

1994 • 1,733 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Multistage carcinogenesis in mouse skin

1992 • 647 citations

Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor.

1993 • 554 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I*

1988 • 481 citations

Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation.

1990 • 404 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2′-deoxyuridine and[³H]thymidine administered by injection or osmotic pump

1990 • 209 citations

Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development

1994 • 208 citations

Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

1997 • 146 citations

Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v‐Ha‐ras oncogene

1993 • 123 citations

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.

1992 • 107 citations

Disproportionate growth in mice with Igf-2 transgenes.

1994 • 102 citations

Evidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors

1987 • 89 citations

Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation

1998 • 80 citations

Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element.

1994 • 77 citations

Epidermal papillomas and carcinomas induced in uninitiated mouse skin by tumor promoters alone contain a point mutation in the 61st codon of the Ha-ras oncogene

1988 • 66 citations

A Bcl-xL transgene promotes malignant conversion of chemically initiated skin papillomas.

1998 • 63 citations

Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents

1987 • 61 citations

Epidermal expression of transforming growth factor‐α in transgenic mice: Induction of spontaneous and 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced papillomas via a mechanism independent of Ha‐ras activation or overexpression

1994 • 53 citations

Severe follicular hyperplasia and spontaneous papilloma formation in transgenic mice expressing theneu oncogene under the control of the bovine keratin 5 promoter

1998 • 47 citations

Tissue‐specific activating mutations of Ha‐ and Ki‐ras oncogenes in skin, lung, and liver tumors induced in mice following transplacental exposure to DMBA

1990 • 43 citations

Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin‐like growth factor‐1

1995 • 42 citations

Altered expression of insulin-like growth factor I and its receptor during multistage carcinogenesis in mouse skin

1996 • 27 citations

Targeting Gene Expression to the Epidermis of Transgenic Mice: Potential Applications to Genetic Skin Disorders

1990 • 20 citations

Transplacental and transgeneration carcinogenic effect of 7,12-dimethylbenz[a]anthracene: relationship with ras oncogene activation

1992 • 20 citations

Expression of mutant p21ras induces insulin-like growth factor 1 secretion in thyroid epithelial cells.

1995 • 10 citations