Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4

1999 • 838 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

IRS-2 pathways integrate female reproduction and energy homeostasis

2000 • 459 citations

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB

1999 • 368 citations

The Drosophila insulin receptor is required for normal growth.

1996 • 337 citations

The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.

1995 • 335 citations

Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.

1996 • 305 citations

A Delayed Wave of Death from Reproduction in Drosophila

1999 • 272 citations

The Effects of Temperature and of Egg-Laying on the Longevity of Drosophila Subobscura

1958 • 264 citations

Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

1999 • 220 citations

The ovo locus is required for sex-specific germ line maintenance in Drosophila.

1987 • 153 citations

Body size parallels insulin-like growth factor I levels but not growth hormone secretory capacity

1984 • 153 citations

Differential Longevity in Mouse Stocks Selected for Early Life Growth Trajectory

2000 • 124 citations

Delayed Aging in Ames Dwarf Mice. Relationships to Endocrine Function and Body Size

2000 • 106 citations

The genetic control of organ growth: insights from Drosophila

2000 • 106 citations

Impact of height and weight on life span.

1992 • 88 citations

The Molecular Genetics of Aging

2000 • 56 citations

p60 Is an Adaptor for the DrosophilaPhosphoinositide 3-Kinase, Dp110

1997 • 40 citations