Leptin regulates proinflammatory immune responses

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

1996 • 900 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

1997 • 815 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

1997 • 798 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

Leptin accelerates the onset of puberty in normal female mice.

1997 • 768 citations

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

1996 • 751 citations

The Macrophage as an Effector Cell

1980 • 628 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Overweight, underweight, and mortality. A prospective study of 48,287 men and women

1996 • 486 citations

Body Weight, Cardiovascular Risk Factors, and Coronary Mortality

1996 • 415 citations

Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by a tumor necrosis factor-alpha-dependent mechanism in murine macrophages.

1993 • 330 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness.

1993 • 207 citations

The 25-Year Health Care Costs of Women Who Remain Overweight After 40 Years of Age

1996 • 78 citations

Lymphocytes play the music but the macrophage calls the tune

1991 • 77 citations

Immune responsiveness in a rat model for type II diabetes (Zucker rat, fa/fa): susceptibility to Candida albicans infection and leucocyte function

1996 • 73 citations

Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing

1994 • 72 citations

Augmented Production of Tumor Necrosis Factor-α in Obese Mice

1995 • 67 citations

Role of reactive oxygen metabolites in murine peritoneal macrophage phagocytosis and phagocytic killing

1996 • 52 citations

Metabolic effects of short-term fasting in obese hyperglycaemic humans and mice.

1987 • 12 citations