Endogenous lipid mediators in the resolution of airway inflammation

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The Acute Respiratory Distress Syndrome

1996 • 5,031 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

The Acute Respiratory Distress Syndrome

2000 • 4,409 citations

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2001 • 3,629 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Points of control in inflammation

2002 • 2,599 citations

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Resolution of inflammation: the beginning programs the end

2005 • 2,353 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

Resolvins

2002 • 1,575 citations

Asthma

2001 • 1,547 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Lipid mediator class switching during acute inflammation: signals in resolution

2001 • 1,355 citations

Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction

2002 • 1,317 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

2000 • 1,136 citations

Resolution of in flammation: state of the art, definitions and terms

2007 • 1,016 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Resolution Phase of Inflammation: Novel Endogenous Anti-Inflammatory and Proresolving Lipid Mediators and Pathways

2006 • 979 citations

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

2003 • 965 citations

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

2005 • 890 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Neutrophilic Inflammation in Severe Persistent Asthma

1999 • 850 citations

Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids

2003 • 840 citations

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

2005 • 828 citations

IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

2001 • 799 citations

Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression

2003 • 781 citations

Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

2001 • 768 citations

Inflammatory Resolution: new opportunities for drug discovery

2004 • 767 citations

Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome

1999 • 755 citations

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

1984 • 728 citations

A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.

1992 • 727 citations

Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following Senescence

2003 • 701 citations

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

1995 • 694 citations

Cell suicide for beginners

1998 • 686 citations

Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins

2005 • 672 citations

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

2000 • 620 citations

Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation

2007 • 601 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

2005 • 574 citations

Granulocyte Apoptosis and Its Role in the Resolution and Control of Lung Inflammation

1999 • 526 citations

Fat-1 mice convert n-6 to n-3 fatty acids

2004 • 524 citations

Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics

2005 • 489 citations

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

2006 • 484 citations

Phospholipase D: a lipid centric review

2005 • 482 citations

Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues

2005 • 458 citations

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

2002 • 441 citations

Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

2006 • 432 citations

Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors

1997 • 427 citations

RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis

2005 • 418 citations

Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

2003 • 392 citations

Association of Cystic Fibrosis with Abnormalities in Fatty Acid Metabolism

2004 • 390 citations

Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis

2006 • 376 citations

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

2002 • 356 citations

Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression

2006 • 343 citations

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

2004 • 338 citations

Chemokines in the systemic organization of immunity

2003 • 335 citations

Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness

2007 • 333 citations

Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils

1995 • 326 citations

Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury

2006 • 323 citations

Leukotrienes: Underappreciated Mediators of Innate Immune Responses

2005 • 316 citations

Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent

2006 • 309 citations

The chemokine receptor D6 limits the inflammatory response in vivo

2005 • 301 citations

Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.

1990 • 297 citations

Role of chemokines in the pathogenesis of asthma

2001 • 296 citations

Apoptotic Cells, through Transforming Growth Factor-β, Coordinately Induce Anti-inflammatory and Suppress Pro-inflammatory Eicosanoid and NO Synthesis in Murine Macrophages

2006 • 295 citations

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction.

1996 • 288 citations

Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia

2002 • 287 citations

Cyclooxygenase 2 Plays a Pivotal Role in the Resolution of Acute Lung Injury

2005 • 268 citations

Activation of Lipoxin a4 Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in Inflammation

2000 • 262 citations

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

2001 • 260 citations

Trihydroxytetraenes: A novel series of compounds formed from arachidonic acid in human leukocytes

1984 • 252 citations

Peroxisome Proliferator–activated Receptors α and γ Down-regulate Allergic Inflammation and Eosinophil Activation

2003 • 250 citations

Protective Effect of Fish Oil Supplementation on Exercise-Induced Bronchoconstriction in Asthma

2006 • 247 citations

Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase–dependent lipoxin production

2005 • 245 citations

Diminished Lipoxin Biosynthesis in Severe Asthma

2005 • 244 citations

15-epi-lipoxin A4–mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation

2004 • 230 citations

Pronounced Eosinophilic Lung Inflammation and Th2 Cytokine Release in Human Lipocalin-Type Prostaglandin D Synthase Transgenic Mice

2002 • 225 citations

Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells.

1996 • 225 citations

Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S‐hydroxy‐DHA

2006 • 219 citations

Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases

2000 • 216 citations

Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers.

1993 • 213 citations

Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon γ and Inhibits Tumor Necrosis Factor α–induced IL-8 Release

1998 • 209 citations

Health and socioeconomic impact of work-related asthma

2003 • 207 citations

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms

2003 • 205 citations

Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions

2005 • 200 citations

Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.

1993 • 196 citations

Resolution of inflammation

2000 • 189 citations

Aspirin-Triggered Lipoxins (15-epi-LX) Are Generated by the Human Lung Adenocarcinoma Cell Line (A549)–Neutrophil Interactions and Are Potent Inhibitors of Cell Proliferation

1996 • 189 citations

Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents

2000 • 187 citations

Cutting Edge: Scavenging of Inflammatory CC Chemokines by the Promiscuous Putatively Silent Chemokine Receptor D6

2003 • 187 citations

Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils.

1990 • 180 citations

Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: Effect of lipocortin 1

1998 • 177 citations

Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics

2000 • 176 citations

Glucocorticoid effects on the production and actions of immune cytokines

1988 • 176 citations

Aspirin-Triggered Lipoxin A4 and B4 Analogs Block Extracellular Signal-Regulated Kinase-Dependent TNF-α Secretion from Human T Cells

2003 • 172 citations

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.

1998 • 162 citations

Effect of rosiglitazone and 15-deoxy-Δ^12,14-prostaglandin J₂on bleomycin-induced lung injury

2005 • 149 citations

Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound

2005 • 148 citations

Expression of Monocyte Chemotactic Protein (MCP)-1, MCP-2, and MCP-3 by Human Airway Smooth-Muscle Cells

1999 • 147 citations

Molecular Basis for the Direct Inhibition of AP-1 DNA Binding by 15-Deoxy-Δ12,14-prostaglandin J2

2003 • 138 citations

Identification of Lipoxin A₄and Its Relationship to the Sulfidopeptide Leukotrienes C₄, D₄, and E₄in the Bronchoalveolar Lavage Fluids Obtained from Patients with Selected Pulmonary Diseases

1990 • 133 citations

Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity

2006 • 130 citations

Cyclooxygenase-2-Derived Prostaglandin E2 and Lipoxin A4 Accelerate Resolution of Allergic Edema inAngiostrongylus costaricensis-Infected Rats: Relationship with Concurrent Eosinophilia

2000 • 129 citations

Lipoxin A4 Regulates Bronchial Epithelial Cell Responses to Acid Injury

2006 • 127 citations

Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro

2005 • 124 citations

Role of 15-DeoxyΔ^12,14 Prostaglandin J₂ and Nrf2 Pathways in Protection against Acute Lung Injury

2005 • 120 citations

Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking

2000 • 120 citations

Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis

2006 • 116 citations

A Chemokine-Dependent Stromal Induction Mechanism for Aberrant Lymphocyte Accumulation and Compromised Lymphatic Return in Rheumatoid Arthritis

2005 • 114 citations

ANNEXIN I IS STORED WITHIN GELATINASE GRANULES OF HUMAN NEUTROPHIL AND MOBILIZED ON THE CELL SURFACE UPON ADHESION BUT NOT PHAGOCYTOSIS

2000 • 112 citations

Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: Conversion to novel 15-oxo and dihydro products

1993 • 106 citations

Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A₄

1999 • 104 citations

Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA.

1998 • 103 citations

Effects of lipoxin A₄on chemotaxis and degranulation of human eosinophils stimulated by platelet-activating factor and N-formyl-L-methionyl-L-leucyl-L-phenylalanine

1994 • 94 citations

Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action.

1987 • 92 citations

Lipoxin A4 Redistributes Myosin IIA and Cdc42 in Macrophages: Implications for Phagocytosis of Apoptotic Leukocytes

2006 • 92 citations

Lipoxins stimulate prostacyclin generation by human endothelial cells

1989 • 89 citations

Human neutrophil annexin I promotes granule aggregation and modulates Ca(2+)-dependent membrane fusion.

1992 • 82 citations

Polyisoprenyl phosphates in intracellular signalling

1997 • 68 citations

Mice Lacking the Multidrug Resistance Protein 1 Are Resistant to Streptococcus pneumoniae-Induced Pneumonia

2001 • 68 citations

LXA₄, aspirin-triggered 15-epi-LXA₄, and their analogs selectively downregulate PMN azurophilic degranulation

1999 • 66 citations

Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells

2005 • 65 citations

A Stable Aspirin-Triggered Lipoxin A4 Analog Blocks Phosphorylation of Leukocyte-Specific Protein 1 in Human Neutrophils

2004 • 65 citations

Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins

2005 • 62 citations

Opposing and Hierarchical Roles of Leukotrienes in Local Innate Immune versus Vascular Responses in a Model of Sepsis

2005 • 61 citations

Aspirin (ASA) regulates 5‐lipoxygenase activity and peroxisome proliferator‐activated receptor α‐mediated CINC‐1 release in rat liver cells: novel actions of lipoxin A₄(LXA₄) and ASA‐triggered 15‐epi‐LXA₄

2002 • 60 citations

Physiological Levels of 15-Deoxy-Δ12,14-Prostaglandin J2 Prime Eotaxin-Induced Chemotaxis on Human Eosinophils through Peroxisome Proliferator-Activated Receptor-γ Ligation

2005 • 60 citations

Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1

1996 • 58 citations

Leukotriene B4 Protects Latently Infected Mice against Murine Cytomegalovirus Reactivation following Allogeneic Transplantation

2005 • 48 citations

CXCR4 expression on monocytes is up‐regulated by dexamethasone and is modulated by autologous CD3⁺ T cells

2002 • 42 citations

Anti-inflammatory cytokines in cystic fibrosis lung disease

2006 • 42 citations

Identification and Functional Characterization of a Presqualene Diphosphate Phosphatase

2006 • 39 citations

Topical Glucocorticoid Therapy Directly Induces Up-Regulation of Functional CXCR4 on Primed T Lymphocytes in the Aqueous Humor of Patients with Uveitis

2004 • 37 citations

Effects of different PPARγ-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis

2002 • 34 citations

Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor (ALX) up-regulation

2006 • 34 citations

Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo

2005 • 32 citations

Aspirin and Decreased Adult-Onset Asthma

2006 • 32 citations

Regulation of phosphatidylinositol 3–kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury

2006 • 30 citations

Suppression of endothelial adhesion molecule up‐regulation with cyclopentenone prostaglandins is dissociated from IκB kinase inhibition and cell death induction

2003 • 30 citations

Carrier-mediated transport of lipoxin A4 in human neutrophils

1994 • 22 citations

Polyisoprenyl phosphates: natural antiinflammatory lipid signals

2002 • 15 citations

OPC-28326, a selective femoral arterial vasodilator, augments ischemia induced angiogenesis

2006 • 7 citations