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Resolution Phase of Inflammation: Novel Endogenous Anti-Inflammatory and Proresolving Lipid Mediators and Pathways

Data up to Jan 2025

Published2006
Citations979
References169

Total Citations Per Year

Abstract

References (169)

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2001 • 3,629 citations

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Points of control in inflammation

2002 • 2,599 citations

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Resolution of inflammation: the beginning programs the end

2005 • 2,353 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

1999 • 2,021 citations

Robbins pathologic basis of disease

1989 • 1,872 citations

Resolvins

2002 • 1,575 citations

Lipid mediator class switching during acute inflammation: signals in resolution

2001 • 1,355 citations

Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction

2002 • 1,317 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET

1929 • 1,140 citations

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

2000 • 1,136 citations

INFLAMMATION AND ATHEROSCLEROSIS

2006 • 1,003 citations

Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells

2003 • 965 citations

Mechanisms of action of docosahexaenoic acid in the nervous system

2001 • 909 citations

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1

2005 • 890 citations

Anti-inflammatory lipid mediators and insights into the resolution of inflammation

2002 • 831 citations

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

2005 • 828 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes

1979 • 812 citations

Novel Docosanoids Inhibit Brain Ischemia-Reperfusion-mediated Leukocyte Infiltration and Pro-inflammatory Gene Expression

2003 • 781 citations

Inflammatory Resolution: new opportunities for drug discovery

2004 • 767 citations

The Healing Hand: Man and Wound in the Ancient World

1975 • 728 citations

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

1984 • 728 citations

Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

2004 • 724 citations

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

1995 • 694 citations

Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins

2005 • 672 citations

Release of Inflammatory Mediators from Stimulated Neutrophils

1980 • 649 citations

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

2005 • 624 citations

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

2000 • 620 citations

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

2005 • 574 citations

The isoprostanes: Unique bioactive products of lipid peroxidation

1997 • 561 citations

C-Reactive Protein and the Risk of Incident Colorectal Cancer

2004 • 543 citations

Role of prostaglandin-mediated vasodilatation in inflammation

1977 • 511 citations

Resolution of Inflammation: A New Paradigm for the Pathogenesis of Periodontal Diseases

2003 • 504 citations

The Healing Hand: Man and Wound in the Ancient World

1992 • 481 citations

The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo

2006 • 467 citations

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor

2002 • 441 citations

Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution

2005 • 440 citations

The development of COX2 inhibitors

2003 • 438 citations

Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes

2006 • 432 citations

Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.

1994 • 431 citations

Aspirin-triggered 15-Epi-Lipoxin A4 (LXA4) and LXA4 Stable Analogues Are Potent Inhibitors of Acute Inflammation: Evidence for Anti-inflammatory Receptors

1997 • 427 citations

RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis

2005 • 418 citations

Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

2003 • 392 citations

Pieces in the Puzzle

1971 • 383 citations

Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis

2006 • 376 citations

Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids

1999 • 374 citations

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

2002 • 356 citations

Resolvins, docosatrienes, and neuroprotectins, novel omega‐3‐derived mediators, and their endogenous aspirin‐triggered epimers

2004 • 343 citations

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors

2006 • 343 citations

Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway

2004 • 338 citations

Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness

2007 • 333 citations

Design of Lipoxin A4 Stable Analogs That Block Transmigration and Adhesion of Human Neutrophils

1995 • 326 citations

New Concepts in Drug Discovery: Collateral Efficacy and Permissive Antagonism

2005 • 313 citations

Cells, tissues, and disease : principles of general pathology

1996 • 306 citations

A Role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense

2005 • 306 citations

Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.

1990 • 297 citations

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction.

1996 • 288 citations

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

2003 • 281 citations

Lipoxin biosynthesis and its impact in inflammatory and vascular events

1994 • 275 citations

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

2001 • 260 citations

Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis

2002 • 257 citations

Lipoxin A4and aspirin-triggered 15-epi-lipoxin A4inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes

2002 • 253 citations

Aspirin triggers antiinflammatory 15-epi-lipoxin A 4 and inhibits thromboxane in a randomized human trial

2004 • 251 citations

Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase–dependent lipoxin production

2005 • 245 citations

Anti-inflammatory circuitry: Lipoxin, aspirin-triggered lipoxins and their receptor ALX

2005 • 237 citations

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.

1998 • 231 citations

The Docosatriene Protectin D1 Is Produced by TH2 Skewing and Promotes Human T Cell Apoptosis via Lipid Raft Clustering

2005 • 231 citations

15-epi-lipoxin A4–mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation

2004 • 230 citations

Resolvin E2: Identification and Anti-Inflammatory Actions: Pivotal Role of Human 5-Lipoxygenase in Resolvin E Series Biosynthesis

2006 • 227 citations

Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion

1999 • 219 citations

Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S‐hydroxy‐DHA

2006 • 219 citations

Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases

2000 • 216 citations

Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers.

1993 • 213 citations

Identification of a Human Enterocyte Lipoxin A4 Receptor That Is Regulated by Interleukin (IL)-13 and Interferon γ and Inhibits Tumor Necrosis Factor α–induced IL-8 Release

1998 • 209 citations

Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitmentin vivo

1999 • 209 citations

Lipoxin A4Analogues Inhibit Leukocyte Recruitment toPorphyromonas gingivalis: A Role for Cyclooxygenase-2 and Lipoxins in Periodontal Disease

2000 • 201 citations

Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1α–initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine–Chemokine Axis

1999 • 198 citations

Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.

1993 • 196 citations

Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy.

1992 • 194 citations

Modulation of Phagocytosis of Apoptotic Neutrophils by Supernatant from Dexamethasone-Treated Macrophages and Annexin-Derived Peptide Ac2–26

2005 • 186 citations

Oxidoreductases in Lipoxin A4 Metabolic Inactivation

2000 • 179 citations

A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution

2004 • 176 citations

Aspirin-Triggered Lipoxin A4 and B4 Analogs Block Extracellular Signal-Regulated Kinase-Dependent TNF-α Secretion from Human T Cells

2003 • 172 citations

Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

1990 • 164 citations

Novel Lipid Mediator Regulators of Endothelial Cell Proliferation and Migration: Aspirin-Triggered-15R-Lipoxin A4and Lipoxin A4

2002 • 159 citations

Metabolic Inactivation of Resolvin E1 and Stabilization of Its Anti-inflammatory Actions

2006 • 158 citations

A β-oxidation-resistant lipoxin A4analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction

2004 • 151 citations

Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis

1999 • 149 citations

15-Epi-16-(Para-Fluorophenoxy)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-epi-Lipoxin A4, Is Protective in Experimental Ischemic Acute Renal Failure

2002 • 142 citations

Lipoxins Are Potential Endogenous Antiinflammatory Mediators in Asthma

2002 • 139 citations

Glucocorticoid-mediated regulation of granulocyte apoptosis and macrophage phagocytosis of apoptotic cells: implications for the resolution of inflammation

2003 • 137 citations

Cyclooxygenase-2-Derived Prostaglandin E2 and Lipoxin A4 Accelerate Resolution of Allergic Edema inAngiostrongylus costaricensis-Infected Rats: Relationship with Concurrent Eosinophilia

2000 • 129 citations

From studies of biochemical mechanism to novel biological mediators: Prostaglandin endoperoxides, thromboxanes, and leukotriences

1983 • 126 citations

The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: Novel oxygenase products from ω-3 polyunsaturated fatty acids

2005 • 124 citations

Analysis of Hydroperoxide-Induced Tyrosyl Radicals and Lipoxygenase Activity in Aspirin-Treated Human Prostaglandin H Synthase-2

1997 • 122 citations

Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa

2003 • 122 citations

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

2006 • 122 citations

Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids

1987 • 122 citations

Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking

2000 • 120 citations

Spatial and Temporal Profiles for Anti-Inflammatory Gene Expression in Leukocytes during a Resolving Model of Peritonitis

2006 • 118 citations

Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions.

2000 • 117 citations

Metchnikoff and the origins of immunology: from metaphor to theory

1992 • 116 citations

Lipoxin A4stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: Role of P-selectin

1997 • 112 citations

Metchnikoff and the Origins of Immunology

1991 • 112 citations

Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina

1984 • 107 citations

Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: Conversion to novel 15-oxo and dihydro products

1993 • 106 citations

Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A4

1999 • 104 citations

Novel Chemical Mediators in the Resolution of Inflammation: Resolvins and Protectins

2006 • 103 citations

Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells

2005 • 103 citations

An Aspirin-Triggered Lipoxin A4 Stable Analog Displays a Unique Topical Anti-Inflammatory Profile

2002 • 100 citations

Lipoxin biosynthesis in inflammatory bowel disease

2005 • 97 citations

Lipoxins: Potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease

2004 • 95 citations

Inflammation Protocols

2003 • 94 citations

Oxidation of docosahexaenoic acid by rat liver microsomes.

1984 • 94 citations

Lipoxin A4 Inhibits Proliferation of Human Lung Fibroblasts Induced by Connective TissueGrowth Factor

2005 • 92 citations

Adventures and excursions in bioassay: the stepping stones to prostacyclin

1983 • 88 citations

Synthesis of lipoxins and other lipoxygenase products by macrophages from the rainbow trout, Oncorhynchus mykiss

1991 • 85 citations

Spatial Requirements for 15-(R)-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic Acid Synthesis within the Cyclooxygenase Active Site of Murine COX-2

2000 • 83 citations

Lipoxin generation by permeabilized human platelets

1992 • 82 citations

Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins—Mediator lipidomic analysis

2005 • 82 citations

Adenosine Up-Regulates Cyclooxygenase-2 in Human Granulocytes: Impact on the Balance of Eicosanoid Generation

2002 • 78 citations

Lipoxin formation in human nasal polyps and bronchial tissue

1990 • 75 citations

Novel 3-Oxa Lipoxin A4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo

2004 • 74 citations

Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase

2004 • 73 citations

Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels

2005 • 70 citations

Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators

2005 • 69 citations

Aspirin Has A Gender-Dependent Impact on Antiinflammatory 15-Epi-Lipoxin A 4 Formation

2005 • 68 citations

Lipoxin A4 Modifies Platelet-Derived Growth Factor-Induced Profibrotic Gene Expression in Human Renal Mesangial Cells

2005 • 68 citations

Rethinking lipid mediators

2005 • 67 citations

Rapid Adhesive Responses of Endothelial Cells and of Neutrophils Induced by Leukotriene B4 are Mediated by Leucocytic Adhesion Protein CD18

1990 • 67 citations

A Stable Aspirin-Triggered Lipoxin A4 Analog Blocks Phosphorylation of Leukocyte-Specific Protein 1 in Human Neutrophils

2004 • 65 citations

Les Prix Nobel : Nobel Prizes, presentations, biographies and lectures

1982 • 65 citations

A magic bullet for mucosal protection…and aspirin is the trigger!

2003 • 63 citations

First total synthesis of 7(S),16(R),17(S)-Resolvin D2, a potent anti-inflammatory lipid mediator

2004 • 62 citations

Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins

2005 • 62 citations

Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia

1991 • 60 citations

Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells

2006 • 56 citations

Development of body weight in the Norwegian population

2005 • 54 citations

Formation and proliferative effects of lipoxins in human bone marrow

1991 • 53 citations

Aspirin-Triggered, Cyclooxygenase-2–Dependent Lipoxin Synthesis Modulates Vascular Tone

2004 • 51 citations

Lipoxin Biosynthesis by Trout Macrophages Involves the Formation of Epoxide Intermediates

1994 • 50 citations

Lipoxygenation of Docosahexaenoic Acid by the Rat Pineal Body

1994 • 48 citations

Adventures and Excursions in Bioassay: The Stepping Stones to Prostacylin

2004 • 46 citations

Aspirin and steroids: new mechanistic findings and avenues for drug discovery

2005 • 43 citations

Lipoxin A4 Counteracts Synergistic Activation of Human Fibroblast-like Synoviocytes

2004 • 42 citations

Lipoxin A4 inhibits acute edema in mice: Implications for the anti-edematogenic mechanism induced by aspirin

2006 • 41 citations

Leukotrienes, Sphingolipids, and Leukocyte Trafficking

2003 • 38 citations

Cooperation between Aspirin-Triggered Lipoxin and Nitric Oxide (NO) Mediates Antiadhesive Properties of 2-(Acetyloxy)benzoic Acid 3-(Nitrooxymethyl)phenyl Ester (NCX-4016) (NO-Aspirin) on Neutrophil-Endothelial Cell Adherence

2004 • 36 citations

Imbalance Between Lipoxin A4 and Leukotriene B4 in Chronic Mastitis-Affected Cows

2003 • 36 citations

A synthetic eicosanoid LX‐mimetic unravels host‐donor interactions in allogeneic BMT‐induced GvHD to reveal an early protective role for host neutrophils

2005 • 34 citations

Lipid Mediator Informatics and Proteomics in Inflammation-Resolution

2006 • 33 citations

Endogenous Chemical Mediators in Anti-Inflammation and Pro-Resolution

2002 • 31 citations

Nitric Oxide (NO)-Releasing Naproxen (HCT-3012 [(S)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid 4-(Nitrooxy)butyl Ester]) Interactions with Aspirin in Gastric Mucosa of Arthritic Rats Reveal a Role for Aspirin-Triggered Lipoxin, Prostaglandins, and NO in Gastric Protection

2004 • 27 citations

Fish oil fix

2005 • 27 citations

Lipoxin formation in fish leucocytes

1991 • 26 citations

Down-regulation of lipoxin A4 receptor by thromboxane A2 signaling in RAW246.7 cells in vitro and bleomycin-induced lung fibrosis in vivo

2004 • 25 citations

Potential vascular roles for lipoxins in the “stop programs” of host defense and inflammation

1995 • 20 citations

Lipoxygenase products in myeloproliferative disorders: increased leukotriene C4 and decreased lipoxin formation in chronic myeloid leukemia.

1991 • 18 citations

The Excitement and Fascination of Science: Reflections by Eminent Scientists

1991 • 17 citations

Pharmacology During the Past Sixty Years

1963 • 10 citations

Interactions Between Lipoxin A4, the Stable Analogue 16‐phenoxy‐lipoxin A4 and Leukotriene B4 in Cytokine Generation by Human Monocytes

2004 • 10 citations

The Neutrophil

2003 • 8 citations

New signaling routes for an old drug: lipoxin A4 might mediate heme oxygenase-1 induction by aspirin. Focus on “Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells”

2005 • 8 citations

First Total Synthesis of 7(S),16(R),17(S)‐Resolvin D2, a Potent Antiinflammatory Lipid Mediator.

2005 • 7 citations

The excitement and fascination of science : a collection of autobiographical and philosophical essays

1965 • 4 citations

Preface

2006 • 1 citations

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Resolution Phase of Inflammation: Novel Endogenous Anti-Inflammatory and Proresolving… (2006) – Annual Review of Immunology | Metascience Observatory Explorer