Asthma

Hay fever, hygiene, and household size.

1989 • 4,910 citations

Asthma and Wheezing in the First Six Years of Life

1995 • 3,773 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

2000 • 1,834 citations

Association of Asthma with Serum IgE Levels and Skin-Test Reactivity to Allergens

1989 • 1,689 citations

Exposure to House-Dust Mite Allergen (Der pI) and the Development of Asthma in Childhood

1990 • 1,677 citations

Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years

1999 • 1,635 citations

Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma

1997 • 1,469 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

The Role of Cockroach Allergy and Exposure to Cockroach Allergen in Causing Morbidity among Inner-City Children with Asthma

1997 • 1,364 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

A 15-Year Follow-up Study of Ventilatory Function in Adults with Asthma

1998 • 1,266 citations

Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid

1994 • 985 citations

Siblings, Day-Care Attendance, and the Risk of Asthma and Wheezing during Childhood

2000 • 947 citations

Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma

1990 • 890 citations

Comparison of a β₂-Agonist, Terbutaline, with an Inhaled Corticosteroid, Budesonide, in Newly Detected Asthma

1991 • 813 citations

Eosinophilia

1998 • 802 citations

Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile

1998 • 797 citations

Interleukin-5, eosinophils, and disease

1992 • 771 citations

Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children

1994 • 762 citations

Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids.

1996 • 721 citations

The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects.

1997 • 719 citations

Treatment of Allergic Asthma with Monoclonal Anti-IgE Antibody

1999 • 708 citations

A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema

1969 • 704 citations

Exposure to an Aeroallergen as a Possible Precipitating Factor in Respiratory Arrest in Young Patients with Asthma

1991 • 689 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Cytokines in asthma

1999 • 646 citations

Measles and atopy in Guinea-Bissau

1996 • 598 citations

Small Airways Dimensions in Asthma and in Chronic Obstructive Pulmonary Disease

1993 • 594 citations

Alveolar tissue inflammation in asthma.

1996 • 575 citations

Effects of Treatment on Airway Inflammation and Thickening of Basement Membrane Reticular Collagen in Asthma: A Quantitative Light and Electron Microscopic Study

1992 • 548 citations

Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis a virus

1997 • 529 citations

Reduced interferon-γ secretion in neonates and subsequent atopy

1994 • 434 citations

Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co‐localization of eotaxin mRNA to bronchial epithelial and endothelial cells

1997 • 429 citations

Interleukin-4 Receptor in Moderate Atopic Asthma

1999 • 421 citations

Eosinophil Chemotactic Chemokines (Eotaxin, Eotaxin-2, RANTES, Monocyte Chemoattractant Protein-3 (MCP-3), and MCP-4), and C-C Chemokine Receptor 3 Expression in Bronchial Biopsies from Atopic and Nonatopic (Intrinsic) Asthmatics

1999 • 415 citations

IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity.

1996 • 413 citations

Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response.

1997 • 412 citations

Effect of Early vs Late Intervention With Inhaled Corticosteroids in Asthma

1995 • 391 citations

The alliance of genes and environment in asthma and allergy

1999 • 370 citations

A Controlled Trial of Immunotherapy for Asthma in Allergic Children

1997 • 349 citations

Transcription factors and asthma

1998 • 324 citations

Airway Inflammation in Mild Intermittent and in Persistent Asthma

1998 • 322 citations

Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia.

1994 • 309 citations

Immediate and Late Airway Response of Allergic Rhinitis Patients to Segmental Antigen Challenge: Characterization of Eosinophil and Mast Cell Mediators

1991 • 281 citations

Randomised, placebo controlled trial of effect of a leukotriene receptor antagonist, montelukast, on tapering inhaled corticosteroids in asthmatic patients

1999 • 274 citations

Modulation of Airway Inflammation by Passive Transfer of Allergen-Specific Th1 and Th2 Cells in a Mouse Model of Asthma

1999 • 273 citations

Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma

1993 • 262 citations

Computed tomography of the lungs in asthma: influence of disease severity and etiology.

1996 • 250 citations

Mite, cat, and cockroach exposure, allergen sensitisation, and asthma in children: a case-control study of three schools

1999 • 223 citations

Molecular basis for selective eosinophil trafficking in asthma: A multistep paradigm☆☆☆

1999 • 222 citations

Family size, childhood infections and atopic diseases. The Aberdeen WHEASE Group

1998 • 219 citations

GROWTH SUPPRESSION BY GLUCOCORTICOID THERAPY

1996 • 217 citations

Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.

1995 • 208 citations

Gene expression of the GATA-3 transcription factor is increased in atopic asthma

1999 • 204 citations

Release of RANTES, MIP-1 α , and MCP-1 into Asthmatic Airways Following Endobronchial Allergen Challenge

1997 • 202 citations

Molecular pathology of allergic disease

2000 • 198 citations

Effect of Inhaled Interleukin-5 on Airway Hyperreactivity and Eosinophilia in Asthmatics

1998 • 179 citations

Chemokines and allergic disease

1999 • 171 citations

Inflammatory Cell Distribution within and along Asthmatic Airways

1998 • 165 citations

Mechanisms of Action of Glucocorticoids in Asthma

1996 • 154 citations

Expression of RANTES mRNA and protein in airways of patients with mild asthma.

1996 • 151 citations

Effect of high dose inhaled fluticasone propionate on airway inflammation in asthma.

1995 • 146 citations

Maturation of immune responses at the beginning of asthma

1999 • 129 citations

Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation.

1995 • 122 citations

Occupational asthma

1997 • 122 citations

Complexity and Redundancy in the Pathogenesis of Asthma: Reassessing the Roles of Mast Cells and T Cells

1997 • 119 citations

Chemokines in Nasal Secretions of Normal Adults Experimentally Infected with Respiratory Syncytial Virus

2000 • 118 citations

Differential Regulation of Eosinophil Adhesion and Transmigration by Pulmonary Microvascular Endothelial Cells

1998 • 103 citations

Two Subphenotypes of Childhood Asthma That Differ in Maternal and Paternal Influences on Asthma Risk

1999 • 93 citations

The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?

1996 • 85 citations

Molecular Mechanisms of Immunoglobulin E Regulation

1998 • 74 citations

G Protein Variation in Respiratory Syncytial Virus Group A Does Not Correlate with Clinical Severity

2000 • 46 citations

Maternal programming in asthma and allergy

1998 • 44 citations

DNA–Based Immunization for Asthma

1999 • 44 citations

Cellular adhesion and its antagonism

1997 • 44 citations

Airway and lung elastic fibre is not reduced in asthma nor in asthmatics following corticosteroid treatment

1995 • 40 citations

Oligonucleotide therapy of allergic asthma☆☆☆

1999 • 36 citations

Mast cell effector mechanisms☆☆☆★

1996 • 35 citations

The use of antibiotics in the first year of life and development of asthma: which comes first?

1999 • 32 citations

Choosing a Long-term Controller Medication in Childhood Asthma

1997 • 31 citations

The Early and Late Asthmatic Response to Allergen

2008 • 22 citations