The Ability of CD40L, but Not Lipopolysaccharide, To Initiate Immunoglobulin Switching to Immunoglobulin G1 Is Explained by Differential Induction of NF-κB/Rel Proteins

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Fundamental Immunology

1994 • 903 citations

Cloning of the p50 DNA binding subunit of NF-κB: Homology to rel and dorsal

1990 • 870 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines.

1989 • 614 citations

Current protocols in immunology

1993 • 551 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Immunoglobulin class switching

1996 • 446 citations

Subclass Restriction of Murine Anti-Carbohydrate Antibodies

1978 • 428 citations

I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity

1997 • 394 citations

Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte

1990 • 391 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

Antibody Class Switching

1996 • 327 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching.

1996 • 304 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

Mitogen- and IL-4-regulated expression of germ-line Ig γ2b transcripts: Evidence for directed heavy chain class switching

1988 • 277 citations

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.

1993 • 261 citations

Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency.

1980 • 258 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain gene

1979 • 230 citations

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

1994 • 214 citations

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

1993 • 206 citations

Interaction of Stat6 and NF-κB: Direct Association and Synergistic Activation of Interleukin-4-Induced Transcription

1998 • 202 citations

Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.

1995 • 201 citations

Dependence of Globin Gene Expression in Mouse Erythroleukemia Cells on the NF-E2 Heterodimer

1995 • 158 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

Multiple Protein-Binding Sites in the 5′-Flanking Region Regulate c-fos Expression

1986 • 133 citations

Multifocal defects in immune responses in RelB-deficient mice.

1997 • 131 citations

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

1996 • 120 citations

Induction of germ-line immunoglobulin heavy chain transcripts by mitogens and interleukins prior to switch recombination

1990 • 120 citations

Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus

1985 • 118 citations

Induction of germ-line gamma 1 and epsilon Ig gene expression in murine B cells. IL-4 and the CD40 ligand-CD40 interaction provide distinct but synergistic signals.

1995 • 113 citations

B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching.

1996 • 111 citations

Regulation of transcription of immunoglobulin germ-line gamma 1 RNA: analysis of the promoter/enhancer.

1992 • 98 citations

c-Rel Is a Target of Pentoxifylline-Mediated Inhibition of T Lymphocyte Activation

1997 • 91 citations

The CD40–CD154 system in anti-infective host defense

1997 • 91 citations

Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells.

1994 • 86 citations

DNA sequence of the murine gamma 1 switch segment reveals novel structural elements.

1986 • 86 citations

Activation of NF-κB/Rel by CD40 Engagement Induces the Mouse Germ Line Immunoglobulin Cγ1 Promoter

1996 • 85 citations

B cells genetically deficient in the c-Rel transactivation domain have selective defects in germline CH transcription and Ig class switching.

1997 • 85 citations

The c-rel protooncogene product represses NF-kappa B p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus.

1993 • 85 citations

I region-restricted antigen presentation by B cell–B lymphoma hybridomas

1982 • 74 citations

Subclass restriction of murine antibodies

1982 • 56 citations

CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.

1996 • 47 citations

B-Cell Differentiation

2020 • 39 citations

Receptor-specific induction of NF-kappaB components in primary B cells

1998 • 38 citations

Antigen receptor cross-linking differentially regulates germ-line CH ribonucleic acid expression in murine B cells.

1995 • 28 citations

IL-4 activates a latent DNA-binding factor that binds a shared IFN-gamma and IL-4 response element present in the germ-line gamma 1 Ig promoter.

1995 • 27 citations

Mitogen and il 4 regulated expression of germline immunoglobulin gamma 2b transcripts evidence for directed heavy chain class switching

1988 • 16 citations

B cell differentiation: I. Development and functional analysis of murine B cells immortalized by a recombinant retrovirus

1992 • 6 citations

I region-restricted antigen presentation by b cell-b lymphoma cell hybridomas. Abstr.

1982 • 1 citations